Search Results - "Mullins, Elwood A."

Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites by Mullins, Elwood A., Dorival, Jonathan, Tang, Gong-Li, Boger, Dale L., Eichman, Brandt F.

“…Microbes produce a broad spectrum of antibiotic natural products, including many DNA-damaging genotoxins. Among the most potent of these are DNA alkylating…”
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A Specialized Citric Acid Cycle Requiring Succinyl-Coenzyme A (CoA):Acetate CoA-Transferase (AarC) Confers Acetic Acid Resistance on the Acidophile Acetobacter aceti by MULLINS, Elwood A, FRANCOIS, Julie A, KAPPOCK, T. Joseph

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A New Family of HEAT-Like Repeat Proteins Lacking a Critical Substrate Recognition Motif Present in Related DNA Glycosylases by Mullins, Elwood A, Shi, Rongxin, Kotsch, Lyle A, Eichman, Brandt F

“…DNA glycosylases are important repair enzymes that eliminate a diverse array of aberrant nucleobases from the genomes of all organisms. Individual bacterial…”
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Function and X-ray crystal structure of Escherichia coli YfdE by Mullins, Elwood A, Sullivan, Kelly L, Kappock, T Joseph

“…Many food plants accumulate oxalate, which humans absorb but do not metabolize, leading to the formation of urinary stones. The commensal bacterium Oxalobacter…”
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Formyl‐coenzyme A (CoA):oxalate CoA‐transferase from the acidophile Acetobacter aceti has a distinctive electrostatic surface and inherent acid stability by Mullins, Elwood A., Starks, Courtney M., Francois, Julie A., Sael, Lee, Kihara, Daisuke, Kappock, T. Joseph

“…Bacterial formyl‐CoA:oxalate CoA‐transferase (FCOCT) and oxalyl‐CoA decarboxylase work in tandem to perform a proton‐consuming decarboxylation that has been…”
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Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway by Mullins, Elwood A., Rodriguez, Alyssa A., Bradley, Noah P., Eichman, Brandt F.

“…The base excision repair (BER) pathway historically has been associated with maintaining genome integrity by eliminating nucleobases with small chemical…”
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Toxicity and repair of DNA adducts produced by the natural product yatakemycin by Mullins, Elwood A, Shi, Rongxin, Eichman, Brandt F

“…Biophysical and structural analyses reveal how the glycosylase AlkD utilizes a mechanism of excision that does not involve base flipping to enable an…”
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Flexibility and distributive synthesis regulate RNA priming and handoff in human DNA polymerase α-primase by Cordoba, John J., Mullins, Elwood A., Salay, Lauren E., Eichman, Brandt F., Chazin, Walter J.

“…[Display omitted] •Polymerase α-Primase is highly flexible.•PRIM2C flexibility is essential for RNA primer length regulation.•Weak affinity of PRIM1 RNA…”
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A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α–primase by Mullins, Elwood A., Salay, Lauren E., Durie, Clarissa L., Bradley, Noah P., Jackman, Jane E., Ohi, Melanie D., Chazin, Walter J., Eichman, Brandt F.

“…The mechanism by which polymerase α–primase (polα–primase) synthesizes chimeric RNA-DNA primers of defined length and composition, necessary for replication…”
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Structure of a DNA glycosylase that unhooks interstrand cross-links by Mullins, Elwood A., Warren, Garrett M., Bradley, Noah P., Eichman, Brandt F.

“…DNA glycosylases are important editing enzymes that protect genomic stability by excising chemically modified nucleobases that alter normal DNA metabolism…”
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The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions by Mullins, Elwood A., Shi, Rongxin, Parsons, Zachary D., Yuen, Philip K., David, Sheila S., Igarashi, Yasuhiro, Eichman, Brandt F.

“…Crystal structures of the DNA glycosylase AlkD with DNA containing various modified bases show that neither substrate recognition nor catalysis use a…”
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A Catalytic Role for C–H/π Interactions in Base Excision Repair by Bacillus cereus DNA Glycosylase AlkD by Parsons, Zachary D, Bland, Joshua M, Mullins, Elwood A, Eichman, Brandt F

“…DNA glycosylases protect genomic integrity by locating and excising aberrant nucleobases. Substrate recognition and excision usually take place in an…”
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Crystal Structures of Acetobacter aceti Succinyl-Coenzyme A (CoA):Acetate CoA-Transferase Reveal Specificity Determinants and Illustrate the Mechanism Used by Class I CoA-Transferases by Mullins, Elwood A, Kappock, T. Joseph

“…Coenzyme A (CoA)-transferases catalyze transthioesterification reactions involving acyl-CoA substrates, using an active-site carboxylate to form covalent acyl…”
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Selective base excision repair of DNA damage by the non‐base‐flipping DNA glycosylase AlkC by Shi, Rongxin, Mullins, Elwood A, Shen, Xing‐Xing, Lay, Kori T, Yuen, Philip K, David, Sheila S, Rokas, Antonis, Eichman, Brandt F

“…DNA glycosylases preserve genome integrity and define the specificity of the base excision repair pathway for discreet, detrimental modifications, and thus,…”
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An HPLC–tandem mass spectrometry method for simultaneous detection of alkylated base excision repair products by Mullins, Elwood A., Rubinson, Emily H., Pereira, Kevin N., Calcutt, M. Wade, Christov, Plamen P., Eichman, Brandt F.

“…•Mass spectrometric detection of multiple alkyl-DNA adducts excised by glycosylases.•Use of HPLC–MS/MS to characterize glycosylase activities.•Methods for…”
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The substrate binding interface of alkylpurine DNA glycosylase AlkD by Mullins, Elwood A., Rubinson, Emily H., Eichman, Brandt F.

“…•First extensive mutational analysis of a new DNA binding architecture.•All but one mutated residue contacting DNA decreased DNA binding affinity.•All mutated…”
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Metal stopping reagents facilitate discontinuous activity assays of the de novo purine biosynthesis enzyme PurE by Sullivan, Kelly L., Huma, Loredana C., Mullins, Elwood A., Johnson, Michael E., Kappock, T. Joseph

“…The conversion of 5-aminoimidazole ribonucleotide (AIR) to 4-carboxy-AIR (CAIR) represents an unusual divergence in purine biosynthesis: microbes and…”
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Functional Dissection of the Bipartite Active Site of the Class I Coenzyme A (CoA)-Transferase Succinyl-CoA:Acetate CoA-Transferase by Murphy, Jesse R, Mullins, Elwood A, Kappock, T Joseph

“…Coenzyme A (CoA)-transferases catalyze the reversible transfer of CoA from acyl-CoA thioesters to free carboxylates. Class I CoA-transferases produce…”
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Base Excision Repair of Bulky DNA Adducts Generated by the Antitumor Drug Yatakemycin by Mullins, Elwood A., Shi, Rongxin, Igarashi, Yasuhiro, Eichman, Brandt F.

“…Threats to genomic integrity are mitigated by DNA glycosylases, which initiate the base excision repair pathway by locating and excising aberrant nucleobases…”
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Selective base excision repair of DNA damage by the non‐base‐flipping DNA glycosylase AlkC by Shi, Rongxin, Mullins, Elwood A., Shen, Xing‐Xing, Lay, Kori T., Yuen, Philip K., David, Sheila S., Rokas, Antonis, Eichman, Brandt F.

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