Search Results - "Mullin, Margaret"

Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition by Roca-Portoles, Alba, Rodriguez-Blanco, Giovanny, Sumpton, David, Cloix, Catherine, Mullin, Margaret, Mackay, Gillian M., O’Neill, Katelyn, Lemgruber, Leandro, Luo, Xu, Tait, Stephen W. G.

“…BH3-mimetics are a new class of anti-cancer drugs that inhibit anti-apoptotic Bcl-2 proteins. In doing so, BH3-mimetics sensitise to cell death. Venetoclax is…”
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Environmental control programs the emergence of distinct functional ensembles from unconstrained chemical reactions by Surman, Andrew J., Rodriguez-Garcia, Marc, Abul-Haija, Yousef M., Cooper, Geoffrey J. T., Gromski, Piotr S., Turk-MacLeod, Rebecca, Mullin, Margaret, Mathis, Cole, Walker, Sara I., Cronin, Leroy

“…Many approaches to the origin of life focus on how the molecules found in biology might be made in the absence of biological processes, from the simplest…”
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ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth by Rath, Nicola, Morton, Jennifer P, Julian, Linda, Helbig, Lena, Kadir, Shereen, McGhee, Ewan J, Anderson, Kurt I, Kalna, Gabriela, Mullin, Margaret, Pinho, Andreia V, Rooman, Ilse, Samuel, Michael S, Olson, Michael F

“…Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death; identifying PDAC enablers may reveal potential therapeutic targets. Expression of the…”
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Microfluidic manufacturing of different niosomes nanoparticles for curcumin encapsulation: Physical characteristics, encapsulation efficacy, and drug release by Obeid, Mohammad A, Khadra, Ibrahim, Albaloushi, Abdullah, Mullin, Margaret, Alyamani, Hanin, Ferro, Valerie A

“…Curcumin, a natural chemical compound found in Curcuma longa that has been used in antitumor and anti-inflammation applications, exhibits very limited water…”
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Nanoparticle-antagomiR based targeting of miR-31 to induce osterix and osteocalcin expression in mesenchymal stem cells by McCully, Mark, Conde, João, V Baptista, Pedro, Mullin, Margaret, Dalby, Matthew J, Berry, Catherine C

“…Mesenchymal stem cells are multipotent adult stem cells capable of generating bone, cartilage and fat, and are thus currently being exploited for regenerative…”
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Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression by Julian, Linda, Naylor, Gregory, Wickman, Grant R, Rath, Nicola, Castino, Giovanni, Stevenson, David, Bryson, Sheila, Munro, June, McGarry, Lynn, Mullin, Margaret, Rice, Alistair, Del Río Hernández, Armandodel, Olson, Michael F

“…Apoptosis is characterized by profound morphological changes, but their physiological purpose is unknown. To characterize the role of apoptotic cell…”
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Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence by Lewis, Natasha S, Lewis, Emily EL, Mullin, Margaret, Wheadon, Helen, Dalby, Matthew J, Berry, Catherine C

“…Multicellular spheroids are an established system for three-dimensional cell culture. Spheroids are typically generated using hanging drop or non-adherent…”
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Transferrin-Bearing, Zein-Based Hybrid Lipid Nanoparticles for Drug and Gene Delivery to Prostate Cancer Cells by Maeyouf, Khadeejah, Sakpakdeejaroen, Intouch, Somani, Sukrut, Meewan, Jitkasem, Ali-Jerman, Hawraa, Laskar, Partha, Mullin, Margaret, MacKenzie, Graeme, Tate, Rothwelle J, Dufès, Christine

“…Gene therapy holds great promise for treating prostate cancer unresponsive to conventional therapies. However, the lack of delivery systems that can transport…”
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Limited Impact of the Protein Corona on the Cellular Uptake of PEGylated Zein Micelles by Melanoma Cancer Cells by Meewan, Jitkasem, Somani, Sukrut, Laskar, Partha, Irving, Craig, Mullin, Margaret, Woods, Stuart, Roberts, Craig W, Alzahrani, Abdullah R, Ferro, Valerie A, McGill, Suzanne, Weidt, Stefan, Burchmore, Richard, Dufès, Christine

“…The formation of a protein layer "corona" on the nanoparticle surface upon entry into a biological environment was shown to strongly influence the interactions…”
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Applications of β-limit dextrin as a matrix forming excipient for fast disintegrating buccal dosage formats by Qi, Xin, Tester, Richard, Liu, Yu, Mullin, Margaret

“…To compare the properties of buccal delivery matrices (wafers) made with dextrin, β-limit dextrin and pre-gelatinised starch. The constituent α-glucans were…”
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Elucidating the function of penetratin and a static magnetic field in cellular uptake of magnetic nanoparticles by Chaudhary, Suman, Smith, Carol Anne, Del Pino, Pablo, de la Fuente, Jesus M, Mullin, Margaret, Hursthouse, Andrew, Stirling, David, Berry, Catherine C

“…Nanotechnology plays an increasingly important role in the biomedical arena. In particular, magnetic nanoparticles (mNPs) have become important tools in…”
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An artificial intelligence enabled chemical synthesis robot for exploration and optimization of nanomaterials by Jiang, Yibin, Salley, Daniel, Sharma, Abhishek, Keenan, Graham, Mullin, Margaret, Cronin, Leroy

“…We present an autonomous chemical synthesis robot for the exploration, discovery, and optimization of nanostructures driven by real-time spectroscopic…”
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Genomic characterization of prophage elements in Clostridium clostridioforme : an understudied component of the intestinal microbiome by Humphrey, Suzanne, Marouli, Angeliki, Thümmler, Katja, Mullin, Margaret, Pritchard, Leighton, Wall, Daniel M

“…Genome sequencing of strain LM41 revealed the presence of an atypically high proportion of mobile genetic elements for this species, with a particularly high…”
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Camptothecin-based dendrimersomes for gene delivery and redox-responsive drug delivery to cancer cells by Laskar, Partha, Somani, Sukrut, Campbell, Sara Jane, Mullin, Margaret, Keating, Patricia, Tate, Rothwelle J, Irving, Craig, Leung, Hing Y, Dufès, Christine

“…Combination therapy involving chemotherapeutic drugs and genes is emerging as a promising strategy to provide a synergistic therapeutic effect, to overcome…”
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A Quiescent, Regeneration-Responsive Tissue Engineered Mesenchymal Stem Cell Bone Marrow Niche Model via Magnetic Levitation by Lewis, Emily Elizabeth Louise, Wheadon, Helen, Lewis, Natasha, Yang, Jingli, Mullin, Margaret, Hursthouse, Andrew, Stirling, David, Dalby, Matthew John, Berry, Catherine Cecilia

“…The bone marrow niche represents a specialized environment that regulates mesenchymal stem cell quiescence and self-renewal, yet fosters stem cell migration…”
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Redox-sensitive, cholesterol-bearing PEGylated poly(propylene imine)-based dendrimersomes for drug and gene delivery to cancer cells by Laskar, Partha, Somani, Sukrut, Altwaijry, Najla, Mullin, Margaret, Bowering, Deborah, Warzecha, Monika, Keating, Patricia, Tate, Rothwelle J, Leung, Hing Y, Dufès, Christine

“…Stimuli-responsive nanocarriers have attracted increased attention as materials that can facilitate drug and gene delivery in cancer therapy. The present study…”
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Regression of Melanoma Following Intravenous Injection of Plumbagin Entrapped in Transferrin-Conjugated, Lipid-Polymer Hybrid Nanoparticles by Sakpakdeejaroen, Intouch, Somani, Sukrut, Laskar, Partha, Mullin, Margaret, Dufès, Christine

“…Plumbagin, a naphthoquinone extracted from the officinal leadwort presenting promising anti-cancer properties, has its therapeutic potential limited by its…”
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Development of transferrin-bearing vesicles encapsulating aspirin for cancer therapy by Sakpakdeejaroen, Intouch, Somani, Sukrut, Mullin, Margaret, Dufès, Christine

“…Originally developed for the treatment of inflammatory disorders, the non-steroidal anti-inflammatory drug aspirin was shown to have a preventive effect…”
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Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization by Rudzka, Dominika A, Spennati, Giulia, McGarry, David J, Chim, Ya-Hua, Neilson, Matthew, Ptak, Aleksandra, Munro, June, Kalna, Gabriela, Hedley, Ann, Moralli, Daniela, Green, Catherine, Mason, Susan, Blyth, Karen, Mullin, Margaret, Yin, Huabing, Olson, Michael F

“…Cancer cells are softer than the normal cells, and metastatic cells are even softer. These changes in biomechanical properties contribute to cancer progression…”
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Tumor regression after intravenous administration of targeted vesicles entrapping the vitamin E α-tocotrienol by Karim, Reatul, Somani, Sukrut, Al Robaian, Majed, Mullin, Margaret, Amor, Rumelo, McConnell, Gail, Dufès, Christine

“…The therapeutic potential of tocotrienol, a member of the vitamin E family of compounds with potent in vitro anti-cancer properties, is limited by its…”
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