Search Results - "Mullin, James M"

Remodeling of Tight Junctions and Enhancement of Barrier Integrity of the CACO-2 Intestinal Epithelial Cell Layer by Micronutrients by Valenzano, Mary Carmen, DiGuilio, Katherine, Mercado, Joanna, Teter, Mimi, To, Julie, Ferraro, Brendan, Mixson, Brittany, Manley, Isabel, Baker, Valerissa, Moore, Beverley A, Wertheimer, Joshua, Mullin, James M

“…The micronutrients zinc, quercetin, butyrate, indole and berberine were evaluated for their ability to induce remodeling of epithelial tight junctions (TJs)…”
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SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1 by Shepley-McTaggart, Ariel, Sagum, Cari A, Oliva, Isabela, Rybakovsky, Elizabeth, DiGuilio, Katie, Liang, Jingjing, Bedford, Mark T, Cassel, Joel, Sudol, Marius, Mullin, James M, Harty, Ronald N

“…Newly emerged SARS-CoV-2 is the cause of an ongoing global pandemic leading to severe respiratory disease in humans. SARS-CoV-2 targets epithelial cells in the…”
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Epithelial barrier function properties of the 16HBE14o- human bronchial epithelial cell culture model by Callaghan, Patrick J, Ferrick, Bryan, Rybakovsky, Elizabeth, Thomas, Sunil, Mullin, James M

“…The human bronchial epithelial cell line, 16HBE14o- (16HBE), is widely used as a model for respiratory epithelial diseases and barrier function. During…”
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Micronutrients at Supplemental Levels, Tight Junctions and Epithelial Barrier Function: A Narrative Review by DiGuilio, Katherine M, Del Rio, Elizabeth A, Harty, Ronald N, Mullin, James M

“…Disease modifiers, whether from cancer, sepsis, systemic inflammation, or microbial pathogens, all appear to induce epithelial barrier leak, with induced…”
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Retinoic acid improves baseline barrier function and attenuates TNF-α-induced barrier leak in human bronchial epithelial cell culture model, 16HBE 14o by Callaghan, Patrick J, Rybakovsky, Elizabeth, Ferrick, Bryan, Thomas, Sunil, Mullin, James M

“…Retinoic acid (RA) has been shown to improve epithelial and endothelial barrier function and development and even suppress damage inflicted by inflammation on…”
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Zinc Supplementation Modifies Tight Junctions and Alters Barrier Function of CACO-2 Human Intestinal Epithelial Layers by Wang, Xuexuan, Valenzano, Mary Carmen, Mercado, Joanna M., Zurbach, E. Peter, Mullin, James M.

“…Background Zinc deficiency is known to result in epithelial barrier leak in the GI tract. Precise effects of zinc on epithelial tight junctions (TJs) are only…”
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Micronutrient Improvement of Epithelial Barrier Function in Various Disease States: A Case for Adjuvant Therapy by DiGuilio, Katherine M, Rybakovsky, Elizabeth, Abdavies, Reza, Chamoun, Romy, Flounders, Colleen A, Shepley-McTaggart, Ariel, Harty, Ronald N, Mullin, James M

“…The published literature makes a very strong case that a wide range of disease morbidity associates with and may in part be due to epithelial barrier leak. An…”
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Calcitriol modifies tight junctions, improves barrier function, and reduces TNF‐α‐induced barrier leak in the human lung‐derived epithelial cell culture model, 16HBE 14o by Rybakovsky, Elizabeth, DiGuilio, Katherine M., Valenzano, Mary Carmen, Geagan, Sophie, Pham, Kaithlyn, Harty, Ronald N., Mullin, James M.

“…Using the 16HBE 14o‐ human airway epithelial cell culture model, calcitriol (Vitamin D) was shown to improve barrier function by two independent metrics –…”
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The effect of displacement distribution asymmetry on the accuracy of phase-shift velocimetry in porous media by Vallatos, Antoine, Shukla, Matsyendra Nath, Mullin, James M., Phoenix, Vernon R., Holmes, William M.

“…Phase-shift velocimetry provided by pulsed magnetic field gradient experiments is the fastest magnetic resonance technique for measuring velocity. However,…”
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Enhancement of tight junctional barrier function by micronutrients: compound-specific effects on permeability and claudin composition by Mercado, Joanna, Valenzano, Mary Carmen, Jeffers, Cameron, Sedlak, Jason, Cugliari, Marina K, Papanikolaou, Eleni, Clouse, Jacob, Miao, Jingya, Wertan, Nina E, Mullin, James M

“…Amid an increasing number of reports in the literature concerning epithelial barrier enhancement by various nutrient compounds, there has never been a study…”
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Zinc reduces epithelial barrier compromise induced by human seminal plasma by Mullin, James M, Diguilio, Katherine M, Valenzano, Mary C, Deis, Rachael, Thomas, Sunil, Zurbach, E Peter, Abdulhaqq, Shaheed, Montaner, Luis J

“…Human semen has the potential to modulate the epithelial mucosal tissues it contacts, as seminal plasma (SP) is recognized to contain both pro- and…”
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Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis by Rajasekaran, Sigrid A, Huynh, Thu P, Wolle, Daniel G, Espineda, Cromwell E, Inge, Landon J, Skay, Anna, Lassman, Charles, Nicholas, Susanne B, Harper, Jeffrey F, Reeves, Anna E, Ahmed, Mansoor M, Leatherman, James M, Mullin, James M, Rajasekaran, Ayyappan K

“…Epithelial-to-mesenchymal transition (EMT) is an important developmental process, participates in tissue repair, and occurs during pathologic processes of…”
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Epithelial tight junctional changes in colorectal cancer tissues by Wang, Xuexuan, Tully, Owen, Ngo, Benjamin, Zitin, Marc, Mullin, James M

“…Colorectal cancer (CRC) is one of the most common cancers in the western world. Early screening and detection could be highly preventative and therefore reduce…”
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Noninvasive monitoring of chick development in ovo using a 7T MRI system from day 12 of incubation through to hatching by Bain, Maureen M., Fagan, Andrew J., Mullin, James M., McNaught, Iain, McLean, John, Condon, Barrie

“…Purpose To determine whether mild cooling of the egg reduces movement to the point where an ultra‐high‐field (7T) MRI system can be used to noninvasively…”
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Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling by Pawlikowski, Jeffrey S., Brock, Claire, Chen, Sheau-Chiann, Al-Olabi, Lara, Nixon, Colin, McGregor, Fiona, Paine, Simon, Chanudet, Estelle, Lambie, Wendy, Holmes, William M., Mullin, James M., Richmond, Ann, Wu, Hong, Blyth, Karen, King, Ayala, Kinsler, Veronica A., Adams, Peter D.

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The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists by Thomas, Sunil, Izard, Jacques, Walsh, Emily, Batich, Kristen, Chongsathidkiet, Pakawat, Clarke, Gerard, Sela, David A, Muller, Alexander J, Mullin, James M, Albert, Korin, Gilligan, John P, DiGuilio, Katherine, Dilbarova, Rima, Alexander, Walker, Prendergast, George C

“…Humans consider themselves discrete autonomous organisms, but recent research is rapidly strengthening the appreciation that associated microorganisms make…”
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Modification of Tight Junction Structure and Permeability by Nutritional Means by Mullin, James M., Skrovanek, Sonja M., Valenzano, Mary Carmen

“…The relative abundance of various claudin proteins of LLC‐PK1 renal epithelial tight junctions (TJs) is modulated by culturing the cells in a medium that is…”
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Omeprazole induces gastric transmucosal permeability to the peptide bradykinin by Gabello, Melissa, Valenzano, Mary Carmen, Zurbach, E Peter, Mullin, James M

“…To investigate omeprazole-induced transepithelial gastric leak and its effects on the permeability of the peptides bradykinin and oxytocin. Rat gastric corpus…”
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S2245 Lipoic Acid Effects on Caco-2 Intestinal Epithelial Barrier Function by DiGuilio, Katherine M., Del Rio, Elizabeth A., Spadea, Rocco, Valenzano, Mary C., Mullin, James M.

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Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo consortium commentary by Jamei, Masoud, Abrahamsson, Bertil, Brown, Jonathan, Bevernage, Jan, Bolger, Michael B., Heimbach, Tycho, Karlsson, Eva, Kotzagiorgis, Evangelos, Lindahl, Anders, McAllister, Mark, Mullin, James M., Pepin, Xavier, Tistaert, Christophe, Turner, David B., Kesisoglou, Filippos

“…[Display omitted] In vitro dissolution experiments are used to qualitatively assess the impact of formulation composition and process changes on the drug…”
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