Search Results - "Mullican, Shannon E."

Uniting GDF15 and GFRAL: Therapeutic Opportunities in Obesity and Beyond by Mullican, Shannon E., Rangwala, Shamina M.

“…Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body…”
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GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates by Mullican, Shannon E, Lin-Schmidt, Xiefan, Chin, Chen-Ni, Chavez, Jose A, Furman, Jennifer L, Armstrong, Anthony A, Beck, Stephen C, South, Victoria J, Dinh, Thai Q, Cash-Mason, Tanesha D, Cavanaugh, Cassandre R, Nelson, Serena, Huang, Chichi, Hunter, Michael J, Rangwala, Shamina M

“…GDF15 has potent anti-obesity effects, but its receptor was unknown. GFRAL has now been identified as the receptor and mediates GDF15's effects through central…”
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Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ by Wang, Fenfen, Mullican, Shannon E., DiSpirito, Joanna R., Peed, Lindsey C., Lazar, Mitchell A.

“…Adipose tissue is an important metabolic organ, the dysfunction of which is associated with the development of obesity, diabetes mellitus, and cardiovascular…”
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Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor by Sun, Zheng, Feng, Dan, Fang, Bin, Mullican, Shannon E., You, Seo-Hee, Lim, Hee-Woong, Everett, Logan J., Nabel, Christopher S., Li, Yun, Selvakumaran, Vignesh, Won, Kyoung-Jae, Lazar, Mitchell A.

“…Histone deacetylases (HDACs) are believed to regulate gene transcription by catalyzing deacetylation reactions. HDAC3 depletion in mouse liver upregulates…”
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Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism by Feng, Dan, Liu, Tao, Sun, Zheng, Bugge, Anne, Mullican, Shannon E, Alenghat, Theresa, Liu, X. Shirley, Lazar, Mitchell A

“…Disruption of the circadian clock exacerbates metabolic diseases, including obesity and diabetes. We show that histone deacetylase 3 (HDAC3) recruitment to the…”
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Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation by Mullican, Shannon E, Gaddis, Christine A, Alenghat, Theresa, Nair, Meera G, Giacomin, Paul R, Everett, Logan J, Feng, Dan, Steger, David J, Schug, Jonathan, Artis, David, Lazar, Mitchell A

“…Macrophages, a key cellular component of inflammation, become functionally polarized in a signal- and context-specific manner. Th2 cytokines such as…”
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HDAC3 is a critical negative regulator of long-term memory formation by McQuown, Susan C, Barrett, Ruth M, Matheos, Dina P, Post, Rebecca J, Rogge, George A, Alenghat, Theresa, Mullican, Shannon E, Jones, Steven, Rusche, James R, Lazar, Mitchell A, Wood, Marcelo A

“…Gene expression is dynamically regulated by chromatin modifications on histone tails, such as acetylation. In general, histone acetylation promotes…”
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Abrogation of nuclear receptors Nr4a3 andNr4a1 leads to development of acute myeloid leukemia by Mullican, Shannon E, Zhang, Shuo, Konopleva, Marina, Ruvolo, Vivian, Andreeff, Michael, Milbrandt, Jeffrey, Conneely, Orla M

“…Nur77 (NR4A1) and Nor-1 (NR4A3) are highly homologous orphan nuclear receptors that regulate the transcription of overlapping target genes. The transcriptional…”
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Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology by Lazar, Mitchell A, Alenghat, Theresa, Meyers, Katherine, Mullican, Shannon E, Leitner, Kirstin, Adeniji-Adele, Adetoun, Avila, Jacqueline, Bu an, Maja, Ahima, Rexford S, Kaestner, Klaus H

“…Rhythmic changes in histone acetylation at circadian clock genes suggest that temporal modulation of gene expression is regulated by chromatin modifications…”
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Cell-Specific Determinants of Peroxisome Proliferator-Activated Receptor γ Function in Adipocytes and Macrophages by Lefterova, Martina I., Steger, David J., Zhuo, David, Qatanani, Mohammed, Mullican, Shannon E., Tuteja, Geetu, Manduchi, Elisabetta, Grant, Gregory R., Lazar, Mitchell A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice by Ramirez-Herrick, Ashley M., Mullican, Shannon E., Sheehan, Andrea M., Conneely, Orla M.

“…The NR4A subfamily of nuclear receptors (NR4A1, NR4A2, and NR4A3) function as transcription factors that transduce diverse extracellular signals into altered…”
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Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions by Hoeksema, Marten A, Gijbels, Marion JJ, Van den Bossche, Jan, van der Velden, Saskia, Sijm, Ayestha, Neele, Annette E, Seijkens, Tom, Stöger, J Lauran, Meiler, Svenja, Boshuizen, Marieke CS, Dallinga‐Thie, Geesje M, Levels, Johannes HM, Boon, Louis, Mullican, Shannon E, Spann, Nathanael J, Cleutjens, Jack P, Glass, Chris K, Lazar, Mitchell A, de Vries, Carlie JM, Biessen, Erik AL, Daemen, Mat JAP, Lutgens, Esther, de Winther, Menno PJ

“…Macrophages are key immune cells found in atherosclerotic plaques and critically shape atherosclerotic disease development. Targeting the functional repertoire…”
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Diet-induced Lethality Due to Deletion of the Hdac3 Gene in Heart and Skeletal Muscle by Sun, Zheng, Singh, Nikhil, Mullican, Shannon E., Everett, Logan J., Li, Li, Yuan, Lijun, Liu, Xi, Epstein, Jonathan A., Lazar, Mitchell A.

“…Many human diseases result from the influence of the nutritional environment on gene expression. The environment interacts with the genome by altering the…”
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Nuclear factor-κB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome by Yan, Qin, Carmody, Ruaidhri J, Qu, Zhonghua, Ruan, Qingguo, Jager, Jennifer, Mullican, Shannon E, Lazar, Mitchell A, Chen, Youhai H

“…Sustained Toll-like receptor (TLR) stimulation continuously activates antimicrobial genes but paradoxically represses inflammatory genes. This phenomenon,…”
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Endoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression by LEFTEROVA, Martina I, MULLICAN, Shannon E, TOMARU, Takuya, QATANANI, Mohammed, SCHUPP, Michael, LAZAR, Mitchell A

“…Endoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression Martina I. Lefterova , Shannon E. Mullican , Takuya Tomaru , Mohammed Qatanani , Michael…”
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Retinol saturase promotes adipogenesis and is downregulated in obesity [Erratum: 2009 Mar. 17, v. 106, no. 11, p. 4571.] by Schupp, Michael, Lefterova, Martina I, Janke, Jürgen, Leitner, Kirstin, Cristancho, Ana G, Mullican, Shannon E, Qatanani, Mohammed, Szwergold, Nava, Steger, David J, Curtin, Joshua C, Kim, Roy J, Suh, Moo-Jin, Albert, Martin R, Engeli, Stefan, Gudas, Lorraine J, Lazar, Mitchell A

“…Adipocyte differentiation is controlled by many transcription factors, but few known downstream targets of these factors are necessary for adipogenesis. Here…”
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Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function by Bugge, Anne, Feng, Dan, Everett, Logan J, Briggs, Erika R, Mullican, Shannon E, Wang, Fenfen, Jager, Jennifer, Lazar, Mitchell A

“…The nuclear receptor Rev-erbα regulates circadian rhythm and metabolism, but its effects are modest and it has been considered to be a secondary regulator of…”
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The orphan nuclear receptors at their 25-year reunion by Mullican, Shannon E, DiSpirito, Joanna R, Lazar, Mitchell A

“…The nuclear receptor superfamily includes many receptors, identified based on their similarity to steroid hormone receptors but without a known ligand. The…”
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Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis by Alenghat, Theresa, Osborne, Lisa C., Saenz, Steven A., Kobuley, Dmytro, Ziegler, Carly G. K., Mullican, Shannon E., Choi, Inchan, Grunberg, Stephanie, Sinha, Rohini, Wynosky-Dolfi, Meghan, Snyder, Annelise, Giacomin, Paul R., Joyce, Karen L., Hoang, Tram B., Bewtra, Meenakshi, Brodsky, Igor E., Sonnenberg, Gregory F., Bushman, Frederic D., Won, Kyoung-Jae, Lazar, Mitchell A., Artis, David

“…This work identifies a role for intestinal epithelial cell (IEC)-intrinsic expression of histone deacetylase 3 in regulating commensal-bacteria-dependent gene…”
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Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia by Mullican, Shannon E, Zhang, Shuo, Konopleva, Marina, Ruvolo, Vivian, Andreeff, Michael, Milbrandt, Jeffrey, Conneely, Orla M

“…Nur77 (NR4A1) and Nor-1 (NR4A3) are highly homologous orphan nuclear receptors that regulate the transcription of overlapping target genes. The transcriptional…”
Get full text