Involvement of Autoimmunity in the Pathogenesis of Aggressive Periodontitis

The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), an...

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Bibliographic Details
Published in:	Journal of dental research Vol. 89; no. 12; pp. 1389 - 1394
Main Authors:	Hendler, A., Mulli, T.K., Hughes, F.J., Perrett, D., Bombardieri, M., Houri-Haddad, Y., Weiss, E.I., Nissim, A.
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-12-2010 International Association for Dental Research SAGE PUBLICATIONS, INC
Subjects:	Adult Aggressive Periodontitis - blood Aggressive Periodontitis - immunology Autoantibodies Autoantibodies - blood Autoantigens - immunology Autoimmunity - immunology Biological and medical sciences Chronic Periodontitis - blood Chronic Periodontitis - immunology Citrulline - immunology Collagen Type I - immunology Collagen Type III - immunology Dentistry Electrophoresis, Polyacrylamide Gel Extracellular Matrix - immunology Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Fluorescence Gingivitis - blood Gingivitis - immunology Humans Hydroxyl Radical - pharmacology Hypochlorous Acid - pharmacology Imaging, Three-Dimensional Intermediate Filament Proteins - immunology Male Medical sciences Middle Aged Nitrates - pharmacology Non tumoral diseases Otorhinolaryngology. Stomatology Oxidants - pharmacology Phosphoproteins - immunology Protein Precursors - immunology Protein Processing, Post-Translational - immunology Reactive Oxygen Species - immunology Young Adult collagen type I collagen type III ROS periodontitis Autoimmunity Human Periodontal disease Collagen type I Periodontitis Stomatology Pathogenesis Collagen type III
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Summary:	The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modified by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0022-0345 1544-0591 1544-0591
DOI:	10.1177/0022034510381903