Search Results - "Muller, Yves A"

De novo prediction of explicit water molecule positions by a novel algorithm within the protein design software MUMBO by Kriegel, Mark, Muller, Yves A.

“…By mediating interatomic interactions, water molecules play a major role in protein–protein, protein–DNA and protein–ligand interfaces, significantly affecting…”
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Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M by Christoffersen, Christina, Obinata, Hideru, Kumaraswamy, Sunil B, Galvani, Sylvain, Ahnström, Josefin, Sevvana, Madhumati, Egerer-Sieber, Claudia, Muller, Yves A, Hla, Timothy, Nielsen, Lars B, Dahlbäck, Björn

“…Protection of the endothelium is provided by circulating sphingosine-1-phosphate (S1P), which maintains vascular integrity. We show that HDL-associated S1P is…”
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The CD83 Molecule - An Important Immune Checkpoint by Grosche, Linda, Knippertz, Ilka, König, Christina, Royzman, Dmytro, Wild, Andreas B, Zinser, Elisabeth, Sticht, Heinrich, Muller, Yves A, Steinkasserer, Alexander, Lechmann, Matthias

“…The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia,…”
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A PROSS-designed extensively mutated estrogen receptor α variant displays enhanced thermal stability while retaining native allosteric regulation and structure by Kriegel, Mark, Wiederanders, Hanna J., Alkhashrom, Sewar, Eichler, Jutta, Muller, Yves A.

“…Protein stability limitations often hamper the exploration of proteins as drug targets. Here, we show that the application of PROSS server algorithms to the…”
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The human cytomegalovirus nuclear egress complex unites multiple functions: Recruitment of effectors, nuclear envelope rearrangement, and docking to nuclear capsids by Marschall, Manfred, Muller, Yves A., Diewald, Benedikt, Sticht, Heinrich, Milbradt, Jens

“…Summary Background Nuclear replication represents a common hallmark of herpesviruses achieved by a number of sequentially unrolled regulatory processes. A…”
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Near-native, site-specific and purification-free protein labeling for quantitative protein interaction analysis by MicroScale Thermophoresis by Bartoschik, Tanja, Galinec, Stefanie, Kleusch, Christian, Walkiewicz, Katarzyna, Breitsprecher, Dennis, Weigert, Sebastian, Muller, Yves A., You, Changjiang, Piehler, Jacob, Vercruysse, Thomas, Daelemans, Dirk, Tschammer, Nuska

“…MicroScale Thermophoresis (MST) is a frequently used method for the quantitative characterization of intermolecular interactions with several advantages over…”
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Cytomegalovirus immediate-early 1 proteins form a structurally distinct protein class with adaptations determining cross-species barriers by Schweininger, Johannes, Scherer, Myriam, Rothemund, Franziska, Schilling, Eva-Maria, Wörz, Sonja, Stamminger, Thomas, Muller, Yves A

“…Restriction factors are potent antiviral proteins that constitute a first line of intracellular defense by blocking viral replication and spread. During…”
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Hydration Structure and Dynamics of Inhibitor-Bound HIV‑1 Protease by Leidner, Florian, Kurt Yilmaz, Nese, Paulsen, Janet, Muller, Yves A, Schiffer, Celia A

“…Water is essential in many biological processes, and the hydration structure plays a critical role in facilitating protein folding, dynamics, and ligand…”
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Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions by Scherer, Myriam, Klingl, Stefan, Sevvana, Madhumati, Otto, Victoria, Schilling, Eva-Maria, Stump, Joachim D, Müller, Regina, Reuter, Nina, Sticht, Heinrich, Muller, Yves A, Stamminger, Thomas

“…PML nuclear bodies (PML-NBs) are enigmatic structures of the cell nucleus that act as key mediators of intrinsic immunity against viral pathogens. PML itself…”
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Exploring the Human Cytomegalovirus Core Nuclear Egress Complex as a Novel Antiviral Target: A New Type of Small Molecule Inhibitors by Alkhashrom, Sewar, Kicuntod, Jintawee, Häge, Sigrun, Schweininger, Johannes, Muller, Yves A, Lischka, Peter, Marschall, Manfred, Eichler, Jutta

“…Nuclear egress is an essential process in the replication of human cytomegalovirus (HCMV), as it enables the migration of newly formed viral capsids from the…”
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Redirecting T cells to Ewing's sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection by Lehner, Manfred, Götz, Gabriel, Proff, Julia, Schaft, Niels, Dörrie, Jan, Full, Florian, Ensser, Armin, Muller, Yves A, Cerwenka, Adelheid, Abken, Hinrich, Parolini, Ornella, Ambros, Peter F, Kovar, Heinrich, Holter, Wolfgang

“…We explored the possibility to target Ewing's sarcoma family of tumors (ESFT) by redirecting T cells. To this aim, we considered NKG2D-ligands (NKG2D-Ls) as…”
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Cross-Species Analysis of Innate Immune Antagonism by Cytomegalovirus IE1 Protein by Rothemund, Franziska, Scherer, Myriam, Schilling, Eva-Maria, Schweininger, Johannes, Muller, Yves A, Stamminger, Thomas

“…The human cytomegalovirus (CMV) immediate early 1 (IE1) protein has evolved as a multifunctional antagonist of intrinsic and innate immune mechanisms. In…”
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Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties by Marschall, Manfred, Häge, Sigrun, Conrad, Marcus, Alkhashrom, Sewar, Kicuntod, Jintawee, Schweininger, Johannes, Kriegel, Mark, Lösing, Josephine, Tillmanns, Julia, Neipel, Frank, Eichler, Jutta, Muller, Yves A, Sticht, Heinrich

“…Herpesviruses uniquely express two essential nuclear egress-regulating proteins forming a heterodimeric nuclear egress complex (core NEC). These core NECs…”
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Crystal Structures of the Global Regulator DasR from Streptomyces coelicolor: Implications for the Allosteric Regulation of GntR/HutC Repressors by Fillenberg, Simon B, Friess, Mario D, Körner, Samuel, Böckmann, Rainer A, Muller, Yves A

“…Small molecule effectors regulate gene transcription in bacteria by altering the DNA-binding affinities of specific repressor proteins. Although the GntR…”
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Structural basis for the recognition of human cytomegalovirus glycoprotein B by a neutralizing human antibody by Spindler, Nadja, Diestel, Uschi, Stump, Joachim D, Wiegers, Anna-Katharina, Winkler, Thomas H, Sticht, Heinrich, Mach, Michael, Muller, Yves A

“…Human cytomegalovirus (HCMV) infections are life-threating to people with a compromised or immature immune system. Upon adhesion, fusion of the virus envelope…”
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Corticosteroid-binding Globulin, a Structural Basis for Steroid Transport and Proteinase-triggered Release by Klieber, Michael A., Underhill, Caroline, Hammond, Geoffrey L., Muller, Yves A.

“…Corticosteroid-binding globulin (CBG) is a serine proteinase inhibitor (serpin) family member that transports glucocorticoids in blood and regulates their…”
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Corticosteroid-binding globulin: structure-function implications from species differences by Gardill, Bernd R, Vogl, Michael R, Lin, Hai-Yan, Hammond, Geoffrey L, Muller, Yves A

“…Corticosteroid-binding globulin (CBG) transports glucocorticoids and progesterone in the blood and thereby modulates the tissue availability of these hormones…”
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Multiple allosteric effectors control the affinity of DasR for its target sites by Tenconi, Elodie, Urem, Mia, Świątek-Połatyńska, Magdalena A., Titgemeyer, Fritz, Muller, Yves A., van Wezel, Gilles P., Rigali, Sébastien

“…The global transcriptional regulator DasR connects N-acetylglucosamine (GlcNAc) utilization to the onset of morphological and chemical differentiation in the…”
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Structural and functional dissection reveals distinct roles of Ca2+-binding sites in the giant adhesin SiiE of Salmonella enterica by Peters, Britta, Stein, Johanna, Klingl, Stefan, Sander, Nathalie, Sandmann, Achim, Taccardi, Nicola, Sticht, Heinrich, Gerlach, Roman G, Muller, Yves A, Hensel, Michael

“…The giant non-fimbrial adhesin SiiE of Salmonella enterica mediates the first contact to the apical site of epithelial cells and enables subsequent invasion…”
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Structural Insight into the Giant Ca2+-Binding Adhesin SiiE: Implications for the Adhesion of Salmonella enterica to Polarized Epithelial Cells by Griessl, Martin H., Schmid, Benedikt, Kassler, Kristin, Braunsmann, Christoph, Ritter, Regina, Barlag, Britta, Stierhof, York-Dieter, Sturm, Karina U., Danzer, Claudia, Wagner, Carolin, Schäffer, Tilman E., Sticht, Heinrich, Hensel, Michael, Muller, Yves A.

“…SiiE from Salmonella enterica is a giant 5,559-residue-long nonfimbrial adhesin that is secreted by a type 1 secretion system (T1SS) and initiates bacterial…”
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