Search Results - "Muller, Y"

The determination and interpretation of the therapeutic index in drug development by Muller, Patrick Y., Milton, Mark N.

“…The therapeutic index of drug candidates — a quantitative relationship between their safety and efficacy, such as the ratio of the highest exposure to a drug…”
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Ribosomal protein RPL26 is the principal target of UFMylation by Walczak, Christopher P., Leto, Dara E., Zhang, Lichao, Riepe, Celeste, Muller, Ryan Y., DaRosa, Paul A., Ingolia, Nicholas T., Elias, Joshua E., Kopito, Ron R.

“…Ubiquitin fold modifier 1 (UFM1) is a small, metazoan-specific, ubiquitin-like protein modifier that is essential for embryonic development. Although…”
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When β-cells fail: lessons from dedifferentiation by Accili, D., Talchai, S. C., Kim-Muller, J. Y., Cinti, F., Ishida, E., Ordelheide, A. M., Kuo, T., Fan, J., Son, J.

“…Diabetes is caused by a combination of impaired responsiveness to insulin and reduced production of insulin by the pancreas. Until recently, the decline of…”
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R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis by Guo, Yuna, Kenney, S Ray, Muller, Carolyn Y, Adams, Sarah, Rutledge, Teresa, Romero, Elsa, Murray-Krezan, Cristina, Prekeris, Rytis, Sklar, Larry A, Hudson, Laurie G, Wandinger-Ness, Angela

“…Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) are attractive therapeutic targets in ovarian cancer based on…”
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Silencing of StRIK in potato suggests a role in periderm related to RNA processing and stress by Boher, Pau, Soler, Marçal, Fernández-Piñán, Sandra, Torrent, Xènia, Müller, Sebastian Y, Kelly, Krystyna A, Serra, Olga, Figueras, Mercè

“…The periderm is a protective barrier crucial for land plant survival, but little is known about genetic factors involved in its development and regulation…”
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Regional gray matter oligodendrocyte- and myelin-related measures are associated with differential susceptibility to stress-induced behavior in rats and humans by Long, Kimberly L. P., Chao, Linda L., Kazama, Yurika, An, Anjile, Hu, Kelsey Y., Peretz, Lior, Muller, Dyana C. Y., Roan, Vivian D., Misra, Rhea, Toth, Claire E., Breton, Jocelyn M., Casazza, William, Mostafavi, Sara, Huber, Bertrand R., Woodward, Steven H., Neylan, Thomas C., Kaufer, Daniela

“…Individual reactions to traumatic stress vary dramatically, yet the biological basis of this variation remains poorly understood. Recent studies demonstrate…”
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Safety Assessment and Dose Selection for First-in-Human Clinical Trials With Immunomodulatory Monoclonal Antibodies by Muller, PY, Brennan, FR

“…Modulating immune responses with monoclonal antibodies (mAbs) that target immune molecules has become a promising therapeutic strategy and is under…”
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The Impact of Animated Banner Ads on Online Consumers: A Feature-Level Analysis Using Eye Tracking by Hong, Weiyin, Cheung, Muller Y. M., Thong, James

“…Despite the popular use of animated banner ads on websites, extant research on the effects of web animation has generated mixed results. We argue that it is…”
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A phase II evaluation of trabectedin in the treatment of advanced, persistent, or recurrent uterine leiomyosarcoma: A gynecologic oncology group study by Monk, Bradley J, Blessing, John A, Street, Daron G, Muller, Carolyn Y, Burke, James J, Hensley, Martee L

“…Abstract Objective To estimate activity and safety of trabectedin 1.5 mg/m2 IV over 24 hours every 3 weeks (1 cycle) in uterine leiomyosarcoma. Methods…”
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A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients by Guo, Yuna, Kenney, S Ray, Cook, Linda, Adams, Sarah F, Rutledge, Teresa, Romero, Elsa, Oprea, Tudor I, Sklar, Larry A, Bedrick, Edward, Wiggins, Charles L, Kang, Huining, Lomo, Lesley, Muller, Carolyn Y, Wandinger-Ness, Angela, Hudson, Laurie G

“…We previously identified the R-enantiomer of ketorolac as an inhibitor of the Rho-family GTPases Rac1 and Cdc42. Rac1 and Cdc42 regulate cancer-relevant…”
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Effects of Animation on Attentional Resources of Online Consumers by Cheung, Muller, Hong, Weiyin, Thong, James

“…Websites commonly use animation to capture the attentional resources of online consumers. While prior research has focused on the effects of animation on…”
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Innovation and Progress in Gynecologic Cancer Care: Faster than Ever by Muller, Carolyn Y., MD

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Magnetic field effects on the finite-frequency noise and ac conductance of a Kondo quantum dot out of equilibrium by Müller, Sarah Y., Pletyukhov, Mikhail, Schuricht, Dirk, Andergassen, Sabine

“…We present analytic results for the finite-frequency current noise and the nonequilibrium ac conductance for a Kondo quantum dot in presence of a magnetic…”
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Loss of end‐differentiated β‐cell phenotype following pancreatic islet transplantation by Anderson, S. J., White, M. G., Armour, S. L., Maheshwari, R., Tiniakos, D., Muller, Y. D., Berishvili, E., Berney, T., Shaw, J. A. M.

“…Replacement of pancreatic β‐cells through deceased donor islet transplantation is a proven therapy for preventing recurrent life‐threatening hypoglycemia in…”
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Processing of gene expression data generated by quantitative real-time RT-PCR by Muller, Patrick Y, Janovjak, Harald, Miserez, André R, Dobbie, Zuzana

“…Quantitative real-time PCR represents a highly sensitive and powerful technique for the quantitation of nucleic acids. It has a tremendous potential for the…”
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The impact of genetic variants on BMI increase during childhood versus adulthood by Hohenadel, M G, Baier, L J, Piaggi, P, Muller, Y L, Hanson, R L, Krakoff, J, Thearle, M S

“…Background: Genetic variants that predispose individuals to obesity may have differing influences during childhood versus adulthood, and additive effects of…”
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High Incidence of ErbB3, ErbB4, and MET Expression in Ovarian Cancer by Davies, Suzy, Holmes, Anna, Lomo, Lesley, Steinkamp, Mara P, Kang, Huining, Muller, Carolyn Y, Wilson, Bridget S

“…Ovarian cancer is the leading cause of death from gynecologic cancers in the United States. Failure may be due to variable expression and/or complex…”
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Phase II study of bevacizumab with liposomal doxorubicin for patients with platinum- and taxane-resistant ovarian cancer by Verschraegen, C.F., Czok, S., Muller, C.Y., Boyd, L., Lee, S.J., Rutledge, T., Blank, S., Pothuri, B., Eberhardt, S., Muggia, F.

“…Suppression of neoangiogenesis and pegylated liposomal doxorubicin (PLD) each contribute to the management of platinum-resistant/refractory ovarian cancer. The…”
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Adapting to climate change and addressing drought – learning from the Red Cross Red Crescent experiences in the Horn of Africa by Muller, Joy C.-Y.

“…The paper presented here is intended to share lessons learnt from the operations that the International Federation of Red Cross and Red Crescent Societies…”
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Phase IB study of the combination of docetaxel, gemcitabine, and bevacizumab in patients with advanced or recurrent soft tissue sarcoma: the Axtell regimen by Verschraegen, C.F., Arias-Pulido, H., Lee, S.-J., Movva, S., Cerilli, L.A., Eberhardt, S., Schmit, B., Quinn, R., Muller, C.Y., Rabinowitz, I., Purdy, M., Snyder, D., Bocklage, T.

“…To assess the response of patients with soft tissue sarcoma (STS) to the combination of docetaxel, bevacizumab, and gemcitabine. Vascular endothelial growth…”
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