Search Results - "Muller, Ittai B."

Computational comparison of common event-based differential splicing tools: practical considerations for laboratory researchers by Muller, Ittai B, Meijers, Stijn, Kampstra, Peter, van Dijk, Steven, van Elswijk, Michel, Lin, Marry, Wojtuszkiewicz, Anna M, Jansen, Gerrit, de Jonge, Robert, Cloos, Jacqueline

“…Computational tools analyzing RNA-sequencing data have boosted alternative splicing research by identifying and assessing differentially spliced genes…”
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Interrelationship between miRNA and splicing factors in pancreatic ductal adenocarcinoma by Supadmanaba, I Gede Putu, Mantini, Giulia, Randazzo, Ornella, Capula, Mjriam, Muller, Ittai B., Cascioferro, Stella, Diana, Patrizia, Peters, Godefridus J., Giovannetti, Elisa

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers because of diagnosis at late stage and inherent/acquired chemoresistance. Recent…”
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Methotrexate Provokes Disparate Folate Metabolism Gene Expression and Alternative Splicing in Ex Vivo Monocytes and GM-CSF- and M-CSF-Polarized Macrophages by Muller, Ittai B, Lin, Marry, Jonge, Robert de, Will, Nico, López-Navarro, Baltasar, Laken, Conny van der, Struys, Eduard A, Oudejans, Cees B M, Assaraf, Yehuda G, Cloos, Jacqueline, Puig-Kröger, Amaya, Jansen, Gerrit

“…Macrophages constitute important immune cell targets of the antifolate methotrexate (MTX) in autoimmune diseases, including rheumatoid arthritis. Regulation of…”
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Activation of LXR Nuclear Receptors Impairs the Anti-Inflammatory Gene and Functional Profile of M-CSF-Dependent Human Monocyte-Derived Macrophages by González de la Aleja, Arturo, Herrero, Cristina, Torres-Torresano, Mónica, de la Rosa, Juan Vladimir, Alonso, Bárbara, Capa-Sardón, Enrique, Muller, Ittai B, Jansen, Gerrit, Puig-Kröger, Amaya, Vega, Miguel A, Castrillo, Antonio, Corbí, Ángel L

“…Liver X Receptors (LXR) control cholesterol metabolism and exert anti-inflammatory actions but their contribution to human macrophage polarization remains…”
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The Macrophage Reprogramming Ability of Antifolates Reveals Soluble CD14 as a Potential Biomarker for Methotrexate Response in Rheumatoid Arthritis by Fuentelsaz-Romero, Sara, Barrio-Alonso, Celia, García Campos, Raquel, Torres Torresano, Mónica, Muller, Ittai B, Triguero-Martínez, Ana, Nuño, Laura, Villalba, Alejandro, García-Vicuña, Rosario, Jansen, Gerrit, Miranda-Carús, María-Eugenia, González-Álvaro, Isidoro, Puig-Kröger, Amaya

“…The identification of "trained immunity/tolerance" in myeloid cells has changed our perception of the performance of monocytes and macrophages during…”
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GSK3β Inhibition Prevents Macrophage Reprogramming by High-Dose Methotrexate by Ríos, Israel, López-Navarro, Baltasar, Torres-Torresano, Mónica, Soler Palacios, Blanca, Simón-Fuentes, Miriam, Domínguez-Soto, Ángeles, Muller, Ittai B., Jansen, Gerrit, Corbí, Ángel L., Puig-Kröger, Amaya

“…Abstract Methotrexate (MTX) is an antifolate drug used as a chemotherapeutic agent for acute lymphoblastic leukemia, where MTX improves patients’ prognosis…”
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Validation of a Prognostic Multivariable Prediction Model for Insufficient Clinical Response to Methotrexate in Early Rheumatoid Arthritis and Its Clinical Application in Evidencio by Gosselt, Helen R., Verhoeven, Maxime M. A., de Rotte, Maurits C. F. J., Pluijm, Saskia M. F., Muller, Ittai B., Jansen, Gerrit, Tekstra, Janneke, Bulatović-Ćalasan, Maja, Heil, Sandra G., Lafeber, Floris P. J. G., Hazes, Johanna M. W., de Jonge, Robert

“…Introduction Methotrexate (MTX) constitutes the first-line therapy in rheumatoid arthritis (RA), yet approximately 30% of the patients do not benefit from MTX…”
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Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis by Muller, Ittai B, Lin, Marry, Lems, Willem F, ter Wee, Marieke M, Wojtuszkiewicz, Anna, Nurmohamed, Michael T, Cloos, Jacqueline, Assaraf, Yehuda G, Jansen, Gerrit, de Jonge, Robert

“…Abstract Objectives An efficient pharmacological response to MTX treatment in RA patients relies on the retention and accumulation of intracellular…”
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Overcoming crizotinib resistance in ALK-rearranged NSCLC with the second-generation ALK-inhibitor ceritinib by Muller, Ittai B, De Langen, Adrianus J, Honeywell, Richard J, Giovannetti, Elisa, Peters, Godefridus J

“…In up to 5% of non-small cell lung cancer (NSCLC) patients, the EML4-ALK translocation drives tumor progression. Treatment with the ALK inhibitor crizotinib is…”
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Anaplastic lymphoma kinase inhibition in metastatic non-small cell lung cancer: clinical impact of alectinib by Muller, Ittai B, de Langen, Adrianus J, Giovannetti, Elisa, Peters, Godefridus J

“…A subset of non-small cell lung cancer (NSCLC) tumors (5%) harbors an anaplastic lymphoma kinase (ALK) translocation that drives tumorigenesis. The clinically…”
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Development and Validation of a Sensitive UHPLC-MS/MS-Based Method for the Analysis of Folylpolyglutamate Synthetase Enzymatic Activity in Peripheral Blood Mononuclear Cells: Application in Rheumatoid Arthritis and Leukemia Patients by Muller, Ittai B, Lin, Marry, Struys, Eduard A, Heydari, Paniz, Hebing, Renske C F, Nurmohamed, Mike T, van der Laken, Conny, Lems, Willem F, Cloos, Jacqueline, Jansen, Gerrit, de Jonge, Robert

“…Folylpolyglutamate synthetase (FPGS) is a crucial enzyme in both cellular folate homeostasis and the intracellular retention of folate analogue drugs such as…”
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Identification of Metabolic Biomarkers in Relation to Methotrexate Response in Early Rheumatoid Arthritis by Gosselt, Helen R, Muller, Ittai B, Jansen, Gerrit, van Weeghel, Michel, Vaz, Frédéric M, Hazes, Johanna M W, Heil, Sandra G, de Jonge, Robert

“…This study aimed to identify baseline metabolic biomarkers for response to methotrexate (MTX) therapy in rheumatoid arthritis (RA) using an untargeted method…”
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Should alectinib or ceritinib be given as first line therapy for ALK positive non-small cell lung cancer patients instead of crizotinib? by Peters, Godefridus J., Muller, Ittai B., Giovannetti, Elisa

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