Search Results - "Muller, Cynthia R."

Aerobic exercise training prevents obesity and insulin resistance independent of the renin angiotensin system modulation in the subcutaneous white adipose tissue by Américo, Anna Laura V, Muller, Cynthia R, Vecchiatto, Bruno, Martucci, Luiz Felipe, Fonseca-Alaniz, Miriam H, Evangelista, Fabiana S

“…We investigate the effects of aerobic exercise training (AET) on the thermogenic response, substrate metabolism and renin angiotensin system (RAS) in the…”
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Safety and efficacy of human polymerized hemoglobin on guinea pig resuscitation from hemorrhagic shock by Muller, Cynthia R., Williams, Alexander T., Walser, Cynthia, Eaker, Allyn M., Sandoval, Jose Luis, Cuddington, Clayton T., Wolfe, Savannah R., Palmer, Andre F., Cabrales, Pedro

“…For the past thirty years, hemoglobin-based oxygen carriers (HBOCs) have been under development as a red blood cell substitute. Side-effects such as…”
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Resuscitation from hemorrhagic shock after traumatic brain injury with polymerized hemoglobin by Muller, Cynthia R., Courelli, Vasiliki, Lucas, Alfredo, Williams, Alexander T., Li, Joyce B., Dos Santos, Fernando, Cuddington, Clayton T., Moses, Savannah R., Palmer, Andre F., Kistler, Erik B., Cabrales, Pedro

“…Traumatic brain injury (TBI) is often accompanied by hemorrhage, and treatment of hemorrhagic shock (HS) after TBI is particularly challenging because the two…”
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Safety profile of high molecular weight polymerized hemoglobins by Muller, Cynthia R., Williams, Alexander T., Munoz, Carlos J., Eaker, Allyn M., Breton, Amanda N., Palmer, Andre F., Cabrales, Pedro

“…Background Hemoglobin (Hb)‐based oxygen (O2) carriers (HBOCs) are being developed as alternatives to red blood cells and blood when these products are…”
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Novel high molecular weight polymerized hemoglobin in a non-obese model of cardiovascular and metabolic dysfunction by Muller, Cynthia R., Williams, Alexander T., Eaker, Allyn M., Walser, Cynthia, Dos Santos, Fernando, Cuddington, Clayton T., Wolfe, Savannah R., Palmer, Andre F., Cabrales, Pedro

“…The widespread adoption of high-calorie, high-fat, high-sucrose diets (HFHSD) has become a global health concern, particularly due to their association with…”
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Increased Hemoglobin Oxygen Affinity With 5-Hydroxymethylfurfural Supports Cardiac Function During Severe Hypoxia by Lucas, Alfredo, Ao-ieong, Eilleen S. Y., Williams, Alexander T., Jani, Vivek P., Muller, Cynthia R., Yalcin, Ozlem, Cabrales, Pedro

“…Acclimatization to hypoxia or high altitude involves physiological adaptation processes, to influence oxygen (O 2 ) transport and utilization. Several natural…”
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Aerobic Physical Exercise Improves Exercise Tolerance and Fasting Glycemia Independent of Body Weight Change in Obese Females by Boschetti, Daniela, Muller, Cynthia R, Américo, Anna Laura V, Vecchiatto, Bruno, Martucci, Luiz Felipe, Pereira, Renata O, Oliveira, Cláudia P, Fiorino, Patricia, Evangelista, Fabiana S, Azevedo-Martins, Anna Karenina

“…Obesity is associated with increased risk of several chronic diseases and the loss of disease-free years, which has increased the focus of much research for…”
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Disruption of beta3 adrenergic receptor increases susceptibility to DIO in mouse by Preite, Nailliw Z, Nascimento, Bruna P P do, Muller, Cynthia R, Américo, Anna Laura V, Higa, Talita S, Evangelista, Fabiana S, Lancellotti, Carmen L, Henriques, Felipe dos Santos, Batista, Miguel Luiz, Bianco, Antonio C, Ribeiro, Miriam O

“…The brown adipose tissue (BAT) mediates adaptive changes in metabolic rate by responding to the sympathetic nervous system through β-adrenergic receptors (AR)…”
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Oxidative phenotype induced by aerobic physical training prevents the obesity-linked insulin resistance without changes in gastrocnemius muscle ACE2-Angiotensin(1-7)-Mas axis by Vecchiatto, Bruno, da Silva, Rafael C, Higa, Talita S, Muller, Cynthia R, Américo, Anna Laura V, Fortunato-Lima, Vanessa C, Ferreira, Marília M, Martucci, Luiz Felipe, Fonseca-Alaniz, Miriam H, Evangelista, Fabiana S

“…We investigate the effect of aerobic physical training (APT) on muscle morphofunctional markers and Angiotensin Converting Enzyme 2/Angiotensin 1-7/Mas…”
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Post-weaning Exposure to High-Fat Diet Induces Kidney Lipid Accumulation and Function Impairment in Adult Rats by Muller, Cynthia R, Leite, Ana Paula O, Yokota, Rodrigo, Pereira, Renata O, Americo, Anna Laura V, Nascimento, Nilberto R F, Evangelista, Fabiana S, Farah, Vera, Fonteles, Manasses C, Fiorino, Patricia

“…We investigated the kidney morphofunctional consequences of high-fat diet intake since post-weaning in adult rats. Male Wistar rats were divided into two…”
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Hypoxically stored RBC resuscitation in a rat model of traumatic brain injury and severe hemorrhagic shock by Muller, Cynthia R., Courelli, Vasiliki, Govender, Krianthan, Omert, Laurel, Yoshida, Tatsuro, Cabrales, Pedro

“…This study aims to investigate the effects of hypoxically stored Red Blood Cells (RBCs) in a rat model of traumatic brain injury followed by severe hemorrhagic…”
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Coadministration of PEGylated apohemoglobin and haptoglobin can limit vascular dysfunction in the microcirculation and prevent acute inflammation by Munoz, Carlos J, Lucas, Daniela, Muller, Cynthia R, Martinez, Jacinda, O'Boyle, Quintin, Pires, Ivan S, Palmer, Andre F, Cabrales, Pedro

“…Unfortunately, during pathological conditions resulting in chronic hemolysis cell-free hemoglobin (Hb) is released into the circulation that releases free…”
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Safety profile and efficacy of low and high oxygen affinity polymerized human hemoglobin in trauma model by Muller, Cynthia R., Courelli, Vasiliki, Cuddington, Clayton T., Moses, Savannah R., Palmer, Andre F., Cabrales, Pedro

“…Hemoglobin (Hb)‐based O2 carriers (HBOC) are being developed as alternatives to blood. Large molecular weight polymerized human Hb (PolyhHb) represents a new…”
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Resuscitation From Hemorrhagic Shock With Fresh and Stored Blood and Polymerized Hemoglobin by Williams, Alexander T., Lucas, Alfredo, Muller, Cynthia R., Munoz, Carlos, Bolden-Rush, Crystal, Palmer, Andre F., Cabrales, Pedro

“…BACKGROUND:Hemoglobin (Hb)-based oxygen carriers (HBOCs) have been proposed as alternatives to blood for decades. Previous studies demonstrated that large…”
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Balance between oxygen transport and blood rheology during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin by Williams, Alexander T, Lucas, Alfredo, Muller, Cynthia R, Bolden-Rush, Crystal, Palmer, Andre F, Cabrales, Pedro

“…Alternatives to blood for use in transfusion medicine have been investigated for decades. An ideal alternative should improve oxygen (O )-carrying capacity and…”
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Control of systemic inflammation through early nitric oxide supplementation with nitric oxide releasing nanoparticles by Williams, Alexander T., Muller, Cynthia R., Govender, Krianthan, Navati, Mahantesh S., Friedman, Adam J., Friedman, Joel M., Cabrales, Pedro

“…Amelioration of immune overactivity during sepsis is key to restoring hemodynamics, microvascular blood flow, and tissue oxygenation, and in preventing…”
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High fat high sucrose diet-induced dyslipidemia in guinea pigs by Muller, Cynthia R, Williams, Alexander T, Eaker, Allyn M, Dos Santos, Fernando, Palmer, Andre F, Cabrales, Pedro

“…Easy access to high-calorie and fat-dense fast food has resulted in unhealthy dietary and lifestyle changes worldwide, which affects both developed and…”
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Attenuating ischemia-reperfusion injury with polymerized albumin by Belcher, Donald A, Williams, Alexander T, Munoz, Carlos J, Muller, Cynthia R, Walser, Cynthia, Palmer, Andre F, Cabrales, Pedro

“…Ischemia-reperfusion injury increased vascular permeability, resulting in fluid extravasation from the intravascular compartment into the tissue space. Fluid…”
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Polymerized human hemoglobin with low and high oxygen affinity in trauma models by Muller, Cynthia R., Courelli, Vasiliki, Walser, Cynthia, Cuddington, Clayton T., Wolfe, Savannah R., Palmer, Andre F., Cabrales, Pedro

“…The present study aimed to compare the ability of tense (T) and relaxed (R) quaternary state polymerized human hemoglobin (PolyhHb) to restore hemodynamics…”
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GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model by Dufu, Kobina, Alt, Carsten, Strutt, Steven, Partridge, James, Tang, Tzechiang, Siu, Vincent, Liao‐Zou, Hilary, Rademacher, Peter, Williams, Alexander T., Muller, Cynthia R., Geng, Xin, Pochron, Mira Patel, Dang, Annie Nguyen, Cabrales, Pedro, Li, Zhe, Oksenberg, Donna, Cathers, Brian E.

“…Summary The pathophysiologic mechanism of sickle cell disease (SCD) involves polymerization of deoxygenated haemoglobin S (HbS), leading to red blood cell…”
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