Search Results - "Muller, Alexander J"

Discovery of IDO1 Inhibitors: From Bench to Bedside by Prendergast, George C, Malachowski, William P, DuHadaway, James B, Muller, Alexander J

“…Small-molecule inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) are emerging at the vanguard of experimental agents in oncology. Here, pioneers of this new…”
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Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond by Muller, Alexander J., Manfredi, Mark G., Zakharia, Yousef, Prendergast, George C.

“…With immunotherapy enjoying a rapid resurgence based on the achievement of durable remissions in some patients with agents that derepress immune function,…”
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Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses by Merlo, Lauren M F, DuHadaway, James B, Montgomery, James D, Peng, Wei-Dan, Murray, Peter J, Prendergast, George C, Caton, Andrew J, Muller, Alexander J, Mandik-Nayak, Laura

“…Indoleamine-2,3-dioxygenase (IDO)1 and IDO2 are two closely related tryptophan catabolizing enzymes encoded by linked genes. The IDO pathway is also…”
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IDO1 and inflammatory neovascularization: bringing new blood to tumor-promoting inflammation by Muller, Alexander J, Mondal, Arpita, Dey, Souvik, Prendergast, George C

“…In parallel with the genetic and epigenetic changes that accumulate in tumor cells, chronic tumor-promoting inflammation establishes a local microenvironment…”
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Indoximod: An Immunometabolic Adjuvant That Empowers T Cell Activity in Cancer by Fox, Eric, Oliver, Thomas, Rowe, Melissa, Thomas, Sunil, Zakharia, Yousef, Gilman, Paul B, Muller, Alexander J, Prendergast, George C

“…Exploding interest in immunometabolism as a source of new cancer therapeutics has been driven in large part by studies of tryptophan catabolism mediated by…”
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The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis through a Nonenzymatic Mechanism by Merlo, Lauren M F, Peng, Weidan, DuHadaway, James B, Montgomery, James D, Prendergast, George C, Muller, Alexander J, Mandik-Nayak, Laura

“…IDO2 is one of two closely related tryptophan catabolizing enzymes induced under inflammatory conditions. In contrast to the immunoregulatory role defined for…”
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A Brief Overview of Cancer Vaccines by Muller, Alexander J., Thomas, Sunil, Prendergast, George C.

“…Vaccine strategies for cancer differ from infectious disease in focusing mainly on clearing rather than preventing disease. Here we survey general vaccine…”
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IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation by Metz, Richard, Smith, Courtney, DuHadaway, James B, Chandler, Phillip, Baban, Babak, Merlo, Lauren M F, Pigott, Elizabeth, Keough, Martin P, Rust, Sonja, Mellor, Andrew L, Mandik-Nayak, Laura, Muller, Alexander J, Prendergast, George C

“…IDO2 is implicated in tryptophan catabolism and immunity but its physiological functions are not well established. Here we report the characterization of mice…”
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Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan by METZ, Richard, DUHADAWAY, James B, KAMASANI, Uma, LAURY-KLEINTOP, Lisa, MUTTER, Alexander J, PRENDERGAST, George C

“…Small-molecule inhibitors of indoleamine 2,3-dioxygenase (IDO) are currently being translated to clinic for evaluation as cancer therapeutics. One issue…”
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IDO is a nodal pathogenic driver of lung cancer and metastasis development by Smith, Courtney, Chang, Mee Young, Parker, Katherine H, Beury, Daniel W, DuHadaway, James B, Flick, Hollie E, Boulden, Janette, Sutanto-Ward, Erika, Soler, Alejandro Peralta, Laury-Kleintop, Lisa D, Mandik-Nayak, Laura, Metz, Richard, Ostrand-Rosenberg, Suzanne, Prendergast, George C, Muller, Alexander J

“…Indoleamine 2,3-dioxygenase (IDO) enzyme inhibitors have entered clinical trials for cancer treatment based on preclinical studies, indicating that they can…”
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Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase by Winters, Maria, DuHadaway, James B., Pham, Khoa N., Lewis-Ballester, Ariel, Badir, Shorouk, Wai, Jenny, Sheikh, Eesha, Yeh, Syun-Ru, Prendergast, George C., Muller, Alexander J., Malachowski, William P.

“…Tryptophan (Trp) catabolizing enzymes play an important and complex role in the development of cancer. Significant evidence implicates them in a range of…”
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Host IDO2 Gene Status Influences Tumor Progression and Radiotherapy Response in KRAS -Driven Sporadic Pancreatic Cancers by Nevler, Avinoam, Muller, Alexander J, Sutanto-Ward, Erika, DuHadaway, James B, Nagatomo, Kei, Londin, Eric, O'Hayer, Kevin, Cozzitorto, Joseph A, Lavu, Harish, Yeo, Theresa P, Curtis, Mark, Villatoro, Tatiana, Leiby, Benjamin E, Mandik-Nayak, Laura, Winter, Jordan M, Yeo, Charles J, Prendergast, George C, Brody, Jonathan R

“…Heritable genetic variations can affect the inflammatory tumor microenvironment, which can ultimately affect cancer susceptibility and clinical outcomes…”
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Editorial: Targeting Indoleamine 2,3-dioxygenases and Tryptophan Dioxygenase for Cancer Immunotherapy by Brochez, Lieve, Kruse, Vibeke, Schadendorf, Dirk, Muller, Alexander J, Prendergast, George C

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Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase by Muller, Alexander J, Sharma, Madhav D, Chandler, Phillip R, DuHadaway, James B, Everhart, Mary E, Johnson, Burles A. III, Kahler, David J, Pihkala, Jeanene, Soler, Alejandro Peralta, Munn, David H, Prendergast, George C, Mellor, Andrew L

“…Topical application of phorbol myristate acetate (PMA) elicits intense local inflammation that facilitates outgrowth of premalignant lesions in skin after…”
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Genotyping and Expression Analysis of IDO2 in Human Pancreatic Cancer: A Novel, Active Target by Witkiewicz, Agnieszka K., MD, Costantino, Christina L., BA, Metz, Richard, PhD, Muller, Alexander J., PhD, Prendergast, George C., PhD, Yeo, Charles J., MD, FACS, Brody, Jonathan R., PhD

“…Background The recently discovered indoleamine 2,3-dioxygenase-2 ( IDO2 ) gene has 2 functional polymorphisms that abolish its enzymatic activity. We…”
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Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors by Kumar, Sanjeev, Malachowski, William P, DuHadaway, James B, LaLonde, Judith M, Carroll, Patrick J, Jaller, Daniel, Metz, Richard, Prendergast, George C, Muller, Alexander J

“…Indoleamine 2,3-dioxygenase (IDO) is emerging as an important new therapeutic target for the treatment of cancer, chronic viral infections, and other diseases…”
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The Immunoregulatory Enzyme IDO Paradoxically Drives B Cell-Mediated Autoimmunity by Scott, Grant N, DuHadaway, James, Pigott, Elizabeth, Ridge, Natalie, Prendergast, George C, Muller, Alexander J, Mandik-Nayak, Laura

“…Rheumatoid arthritis (RA) is a chronic and debilitating inflammatory autoimmune disease of unknown etiology. As with a variety of autoimmune disorders,…”
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Peptide vaccination directed against IDO1-expressing immune cells elicits CD8+ and CD4+ T-cell-mediated antitumor immunity and enhanced anti-PD1 responses by Dey, Souvik, Sutanto-Ward, Erika, Kopp, Katharina L, DuHadaway, James, Mondal, Arpita, Ghaban, Dema, Lecoq, Inés, Zocca, Mai-Britt, Merlo, Lauren M F, Mandik-Nayak, Laura, Andersen, Mads Hald, Pedersen, Ayako Wakatsuki, Muller, Alexander J

“…BackgroundThe tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which subverts T-cell immunity at multiple levels, is itself subject to…”
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Structure−Activity Study of Brassinin Derivatives as Indoleamine 2,3-Dioxygenase Inhibitors by Gaspari, Paul, Banerjee, Tinku, Malachowski, William P, Muller, Alexander J, Prendergast, George C, DuHadaway, James, Bennett, Shauna, Donovan, Ashley M

“…A screen of indole-based structures revealed the natural product brassinin to be a moderate inhibitor of indoleamine 2,3-dioxygenase (IDO), a new cancer…”
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Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer by Prendergast, George C, Malachowski, William J, Mondal, Arpita, Scherle, Peggy, Muller, Alexander J

“…The tryptophan catabolic enzyme indoleamine 2,3-dioxygenase-1 (IDO1) has attracted enormous attention in driving cancer immunosuppression, neovascularization,…”
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