Search Results - "Mullen, Peter J"

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition by Mullen, Peter J., Garcia, Gustavo, Purkayastha, Arunima, Matulionis, Nedas, Schmid, Ernst W., Momcilovic, Milica, Sen, Chandani, Langerman, Justin, Ramaiah, Arunachalam, Shackelford, David B., Damoiseaux, Robert, French, Samuel W., Plath, Kathrin, Gomperts, Brigitte N., Arumugaswami, Vaithilingaraja, Christofk, Heather R.

“…Viruses hijack host cell metabolism to acquire the building blocks required for replication. Understanding how SARS-CoV-2 alters host cell metabolism may lead…”
Get full text

An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer by Longo, Joseph, Mullen, Peter J., Yu, Rosemary, van Leeuwen, Jenna E., Masoomian, Mehdi, Woon, Dixon T.S., Wang, Yuzhuo, Chen, Eric X., Hamilton, Robert J., Sweet, Joan M., van der Kwast, Theodorus H., Fleshner, Neil E., Penn, Linda Z.

“…The statin family of cholesterol-lowering drugs has been shown to induce tumor-specific apoptosis by inhibiting the rate-limiting enzyme of the mevalonate…”
Get full text

The interplay between cell signalling and the mevalonate pathway in cancer by Mullen, Peter J., Yu, Rosemary, Longo, Joseph, Archer, Michael C., Penn, Linda Z.

“…Key Points Mevalonate (MVA) pathway metabolites are essential for cancer cell survival and growth. Expression of the genes encoding MVA pathway enzymes is…”
Get full text

MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity by WASYLISHEN, Amanda R, CHAN-SENG-YUE, Michelle, RAUGHT, Brian, BOUTROS, Paul C, PENN, Linda Z, BROS, Christina, DINGAR, Dharmendra, TU, William B, KALKAT, Manpreet, CHAN, Pak-Kei, MULLEN, Peter J, LING HUANG, MEYER, Natalie

“…Despite its central role in human cancer, MYC deregulation is insufficient by itself to transform cells. Because inherent mechanisms of neoplastic control…”
Get full text

Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth by Krall, Abigail S., Mullen, Peter J., Surjono, Felicia, Momcilovic, Milica, Schmid, Ernst W., Halbrook, Christopher J., Thambundit, Apisadaporn, Mittelman, Steven D., Lyssiotis, Costas A., Shackelford, David B., Knott, Simon R.V., Christofk, Heather R.

“…Mitochondrial respiration is critical for cell proliferation. In addition to producing ATP, respiration generates biosynthetic precursors, such as aspartate,…”
Get full text

The aging tumor metabolic microenvironment by Pilley, Steven E, Esparza, Edgar, Mullen, Peter J

“…Despite the higher incidence of cancer with increasing age, few preclinical or clinical studies incorporate age. This, coupled with an aging world population,…”
Get full text

Methionine restriction forces Epstein-Barr virus out of latency by Kashyap, Sriraksha Bharadwaj, Mulondo, Racheal, Mullen, Peter J.

Get full text

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization by Sullivan, William J., Mullen, Peter J., Schmid, Ernst W., Flores, Aimee, Momcilovic, Milica, Sharpley, Mark S., Jelinek, David, Whiteley, Andrew E., Maxwell, Matthew B., Wilde, Blake R., Banerjee, Utpal, Coller, Hilary A., Shackelford, David B., Braas, Daniel, Ayer, Donald E., de Aguiar Vallim, Thomas Q., Lowry, William E., Christofk, Heather R.

“…The metabolic state of a cell is influenced by cell-extrinsic factors, including nutrient availability and growth factor signaling. Here, we present…”
Get full text

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis by Tu, William B., Shiah, Yu-Jia, Lourenco, Corey, Mullen, Peter J., Dingar, Dharmendra, Redel, Cornelia, Tamachi, Aaliya, Ba-Alawi, Wail, Aman, Ahmed, Al-awar, Rima, Cescon, David W., Haibe-Kains, Benjamin, Arrowsmith, Cheryl H., Raught, Brian, Boutros, Paul C., Penn, Linda Z.

“…MYC is an oncogenic driver that regulates transcriptional activation and repression. Surprisingly, mechanisms by which MYC promotes malignant transformation…”
Get full text

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress by Sriskanthadevan, Shrivani, Jeyaraju, Danny V., Chung, Timothy E., Prabha, Swayam, Xu, Wei, Skrtic, Marko, Jhas, Bozhena, Hurren, Rose, Gronda, Marcela, Wang, Xiaoming, Jitkova, Yulia, Sukhai, Mahadeo A., Lin, Feng-Hsu, Maclean, Neil, Laister, Rob, Goard, Carolyn A., Mullen, Peter J., Xie, Stephanie, Penn, Linda Z., Rogers, Ian M., Dick, John E., Minden, Mark D., Schimmer, Aaron D.

“…Mitochondrial respiration is a crucial component of cellular metabolism that can become dysregulated in cancer. Compared with normal hematopoietic cells, acute…”
Get full text

Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins by Yu, Rosemary, Longo, Joseph, van Leeuwen, Jenna E, Mullen, Peter J, Ba-Alawi, Wail, Haibe-Kains, Benjamin, Penn, Linda Z

“…The statin family of drugs preferentially triggers tumor cell apoptosis by depleting mevalonate pathway metabolites farnesyl pyrophosphate (FPP) and…”
Get full text

Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt by Mullen, Peter J., Zahno, Anja, Lindinger, Peter, Maseneni, Swarna, Felser, Andrea, Krähenbühl, Stephan, Brecht, Karin

“…Statins are widely used to prevent cardiovascular diseases. They are well-tolerated, with side-effects mainly seen in skeletal muscle. How these side-effects…”
Get full text

Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop by PANDYRA, Aleksandra, MULLEN, Peter J, PENN, Linda Z, KALKAT, Manpreet, ROSEMARY YU, PONG, Janice T, ZHIHUA LI, TRUDEL, Suzanne, LANG, Karl S, MINDEN, Mark D, SCHIMMER, Aaron D

“…New therapies are urgently needed for hematologic malignancies, especially in patients with relapsed acute myelogenous leukemia (AML) and multiple myeloma. We…”
Get full text

Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo by Bonifacio, Annalisa, Mullen, Peter J., Mityko, Ileana Scurtu, Navegantes, Luiz C., Bouitbir, Jamal, Krähenbühl, Stephan

“…Simvastatin is effective and well tolerated, with adverse reactions mainly affecting skeletal muscle. Important mechanisms for skeletal muscle toxicity include…”
Get full text

A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer by Longo, Joseph, Hamilton, Robert J., Masoomian, Mehdi, Khurram, Najia, Branchard, Emily, Mullen, Peter J., Elbaz, Mohamad, Hersey, Karen, Chadwick, Dianne, Ghai, Sangeet, Andrews, David W., Chen, Eric X., van der Kwast, Theodorus H., Fleshner, Neil E., Penn, Linda Z.

“…Background Statins inhibit HMG-CoA reductase, the rate-limiting enzyme of the mevalonate pathway. Epidemiological and pre-clinical evidence support an…”
Get full text

The Metabolic Relationship Between Viral Infection and Cancer by Mullen, Peter J, Christofk, Heather R

“…Viruses are fundamental tools in cancer research. They were used to discover the first oncogenes in the 1970s, and they are now being modified for use as…”
Get full text

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death by Pandyra, Aleksandra A, Mullen, Peter J, Goard, Carolyn A, Ericson, Elke, Sharma, Piyush, Kalkat, Manpreet, Yu, Rosemary, Pong, Janice T, Brown, Kevin R, Hart, Traver, Gebbia, Marinella, Lang, Karl S, Giaever, Guri, Nislow, Corey, Moffat, Jason, Penn, Linda Z

“…The mevalonate (MVA) pathway is often dysregulated or overexpressed in many cancers suggesting tumor dependency on this classic metabolic pathway. Statins,…”
Get full text

Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells by Goard, Carolyn A., Chan-Seng-Yue, Michelle, Mullen, Peter J., Quiroga, Ariel D., Wasylishen, Amanda R., Clendening, James W., Sendorek, Dorota H. S., Haider, Syed, Lehner, Richard, Boutros, Paul C., Penn, Linda Z.

“…Statins, routinely used to treat hypercholesterolemia, selectively induce apoptosis in some tumor cells by inhibiting the mevalonate pathway. Recent clinical…”
Get full text

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells by Halbrook, Christopher J, Thurston, Galloway, Boyer, Seth, Anaraki, Cecily, Jiménez, Jennifer A, McCarthy, Amy, Steele, Nina G, Kerk, Samuel A, Hong, Hanna S, Lin, Lin, Law, Fiona V, Felton, Catherine, Scipioni, Lorenzo, Sajjakulnukit, Peter, Andren, Anthony, Beutel, Alica K, Singh, Rima, Nelson, Barbara S, Van Den Bergh, Fran, Krall, Abigail S, Mullen, Peter J, Zhang, Li, Batra, Sandeep, Morton, Jennifer P, Stanger, Ben Z, Christofk, Heather R, Digman, Michelle A, Beard, Daniel A, Viale, Andrea, Zhang, Ji, Crawford, Howard C, Pasca di Magliano, Marina, Jorgensen, Claus, Lyssiotis, Costas A

“…The pancreatic tumor microenvironment drives deregulated nutrient availability. Accordingly, pancreatic cancer cells require metabolic adaptations to survive…”
Get full text

Largen: A Molecular Regulator of Mammalian Cell Size Control by Yamamoto, Kazuo, Gandin, Valentina, Sasaki, Masato, McCracken, Susan, Li, Wanda, Silvester, Jennifer Liepa, Elia, Andrew J., Wang, Feng, Wakutani, Yosuke, Alexandrova, Roumiana, Oo, Yathor D, Mullen, Peter J., Inoue, Satoshi, Itsumi, Momoe, Lapin, Valentina, Haight, Jillian, Wakeham, Andrew, Shahinian, Arda, Ikura, Mitsuhiko, Topisirovic, Ivan, Sonenberg, Nahum, Mak, Tak W.

“…Little is known about how mammalian cells maintain cell size homeostasis. We conducted a novel genetic screen to identify cell-size-controlling genes and…”
Get full text