Search Results - "Mullen, Patrick G."

Differential activation of alveolar, pulmonary arterial, and systemic arterial neutrophils demonstrates the existence of distinct neutrophil subpopulations in experimental sepsis by Windsor, A C, Carey, P D, Sugerman, H J, Mullen, P G, Walsh, C J, Fisher, B J, Blocher, C R, Fowler, 3rd, A A

“…Neutrophils (PMNs) are considered key cellular mediators of sepsis induced acute lung injury. PMN activation is manifest by increased beta 2 integrin…”
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Monoclonal antibody to tumor necrosis factor alpha attenuates cardiopulmonary dysfunction in porcine gram-negative sepsis by Walsh, C J, Sugerman, H J, Mullen, P G, Carey, P D, Leeper-Woodford, S K, Jesmok, G J, Ellis, E F, Fowler, A A

“…Tumor necrosis factor (TNF) is implicated in the pathophysiology of gram-negative sepsis. This study examined physiologic and biochemical effects of…”
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Delayed tumor necrosis factor alpha blockade attenuates pulmonary dysfunction and metabolic acidosis associated with experimental gram-negative sepsis by Windsor, A C, Mullen, P G, Walsh, C J, Fisher, B J, Blocher, C R, Jesmok, G, Fowler, 3rd, A A, Sugerman, H J

“…To ascertain the effect of delayed tumor necrosis factor alpha (TNF-alpha) on the evolution of systemic and pulmonary injury after the onset of sepsis…”
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Tumor necrosis factor-α blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation by WINDSOR, A. C. J, WALSH, C. J, MULLEN, P. G, COOK, D. J, FISHER, B. J, BLOCHER, C. R, LEEPER-WOODFORD, S. K, SUGERMAN, H. J, FOWLER, A. A

“…Tumor necrosis factor (TNF alpha), both by direct action and by trafficking cells of the immune system, is implicated in cardiopulmonary derangements and…”
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Tumor Necrosis Factor-α and Interleukin-6 Selectively Regulate Neutrophil Function in Vitro by Mullen, Patrick G., Windsor, Alastair C.J., Walsh, Ciaran J., Fowler, Alpha A., Sugerman, Harvey J.

“…The neutrophil is an important effector cell of the host response to sepsis. Tumor necrosis factor-α (TNF-α), a cytokine mediator of the septic response, is…”
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Effect of triiodothyronine on postischemic myocardial function in the isolated heart by Kadletz, Margit, Mullen, Patrick G., Ding, Mai, Wolfe, Luke G., Wechsler, Andrew S.

“…Thyroid dysfunction has been shown to have a significant impact on hemodynamic status and cardiac function. The purpose of this study was to determine the…”
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Release of endothelin in relation to tumor necrosis factor-alpha in porcine Pseudomonas aeruginosa-induced septic shock by Han, J J, Windsor, A, Drenning, D H, Leeper-Woodford, S, Mullen, P G, Bechard, D E, Sugerman, H J, Fowler, 3rd, A A

“…Septic shock is characterized by surges of tumor necrosis factor-alpha (TNF-alpha) along with myocardial dysfunction and systemic hypotension. TNF-alpha…”
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Pulmonary Artery Endothelial Cell Function in Swine Pseudomonas Sepsis by Kadletz, Margit, Dignan, Rebecca J., Mullen, Patrick G., Windsor, Alastair C.J., Sugerman, Harvey J., Wechsler, Andrew S.

“…A substantial increase in pulmonary vascular resistance is associated with sepsis and its sequelae (sepsis syndrome and septic shock). It is postulated that…”
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Monoclonal antibody to tumor necrosis factor-alpha attenuates plasma interleukin-6 levels in porcine gram-negative sepsis by Mullen, P G, Fisher, B J, Walsh, C J, Susskind, B M, Leeper-Woodford, S K, Jesmok, G J, Fowler, A A, Sugerman, H J

“…This study examined the kinetics of IL-6 release into the systemic circulation in a porcine model of bacterial sepsis induced by infusion of live Pseudomonas…”
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Combined ibuprofen and monoclonal antibody to tumor necrosis factor-alpha attenuate hemodynamic dysfunction and sepsis-induced acute lung injury by Mullen, P G, Windsor, A C, Walsh, C J, Blocher, C R, Fisher, B J, Leeper-Woodford, S K, Jesmok, G J, Fowler, 3rd, A A, Sugerman, H J

“…A number of key mediators are implicated in the pathophysiology of sepsis. In previous studies of a septic porcine model, ibuprofen pretreatment prevented the…”
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