Search Results - "Mullaly, Sarah C."

The omics of triple-negative breast cancers by Xu, Hong, Eirew, Peter, Mullaly, Sarah C, Aparicio, Samuel

“…Triple-negative breast cancers (TNBC) do not represent a single disease subgroup and are often aggressive breast cancers with poor prognoses. Unlike…”
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Synthetic Cationic Peptide IDR-1002 Provides Protection against Bacterial Infections through Chemokine Induction and Enhanced Leukocyte Recruitment by Nijnik, Anastasia, Madera, Laurence, Ma, Shuhua, Waldbrook, Matthew, Elliott, Melissa R, Easton, Donna M, Mayer, Matthew L, Mullaly, Sarah C, Kindrachuk, Jason, Jenssen, Havard, Hancock, Robert E. W

“…With the rapid rise in the incidence of multidrug resistant infections, there is substantial interest in host defense peptides as templates for production of…”
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Use of Artificial Intelligence in the Design of Small Peptide Antibiotics Effective against a Broad Spectrum of Highly Antibiotic-Resistant Superbugs by Cherkasov, Artem, Hilpert, Kai, Jenssen, Håvard, Fjell, Christopher D, Waldbrook, Matt, Mullaly, Sarah C, Volkmer, Rudolf, Hancock, Robert E.W

“…Increased multiple antibiotic resistance in the face of declining antibiotic discovery is one of society’s most pressing health issues. Antimicrobial peptides…”
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Vav1 Is Essential for Mechanotactic Crawling and Migration of Neutrophils out of the Inflamed Microvasculature by Phillipson, Mia, Heit, Bryan, Parsons, Sean A, Petri, Bjorn, Mullaly, Sarah C, Colarusso, Pina, Gower, R. Michael, Neely, Gregory, Simon, Scott I, Kubes, Paul

“…Mac-1-dependent crawling is a new step in the leukocyte recruitment cascade that follows LFA-1-dependent adhesion and precedes emigration. Neutrophil adhesion…”
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Assessing the role of CD103 in immunity to an intestinal helminth parasite by Mullaly, Sarah C, Burrows, Kyle, Antignano, Frann, Zaph, Colby

“…In the intestine, the integrin CD103 is expressed on a subset of T regulatory (T(reg)) cells and a population of dendritic cells (DCs) that produce retinoic…”
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Mast cell‐expressed complement receptor, not TLR2, is the main detector of zymosan in peritonitis by Mullaly, Sarah C., Kubes, Paul

“…The in vitro macrophage response to zymosan has been attributed to Toll‐like receptor 2 (TLR2). Whether TLR2 is obligatory for the zymosan‐induced in vivo…”
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Requirement for core 2 O-glycans for optimal resistance to helminth infection by Mullaly, Sarah C, Oudhoff, Menno J, Min, Paul H, Burrows, Kyle, Antignano, Frann, Rattray, David G, Chenery, Alistair, McNagny, Kelly M, Ziltener, Hermann J, Zaph, Colby

“…The migration of lymphocytes to the small intestine is controlled by expression of the integrin α4β7 and the chemokine receptor CCR9. However, the molecules…”
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Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer by McPherson, Andrew, Roth, Andrew, Laks, Emma, Masud, Tehmina, Bashashati, Ali, Zhang, Allen W, Ha, Gavin, Biele, Justina, Yap, Damian, Wan, Adrian, Prentice, Leah M, Khattra, Jaswinder, Smith, Maia A, Nielsen, Cydney B, Mullaly, Sarah C, Kalloger, Steve, Karnezis, Anthony, Shumansky, Karey, Siu, Celia, Rosner, Jamie, Chan, Hector Li, Ho, Julie, Melnyk, Nataliya, Senz, Janine, Yang, Winnie, Moore, Richard, Mungall, Andrew J, Marra, Marco A, Bouchard-Côté, Alexandre, Gilks, C Blake, Huntsman, David G, McAlpine, Jessica N, Aparicio, Samuel, Shah, Sohrab P

“…Sohrab Shah, Samuel Aparicio and colleagues analyze whole genomes and single cells from ovarian cancers in the peritoneal cavity to establish patterns of…”
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Systematic analysis of somatic mutations impacting gene expression in 12 tumour types by Ding, Jiarui, McConechy, Melissa K., Horlings, Hugo M., Ha, Gavin, Chun Chan, Fong, Funnell, Tyler, Mullaly, Sarah C., Reimand, Jüri, Bashashati, Ali, Bader, Gary D., Huntsman, David, Aparicio, Samuel, Condon, Anne, Shah, Sohrab P.

“…We present a novel hierarchical Bayes statistical model, xseq, to systematically quantify the impact of somatic mutations on expression profiles. We establish…”
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Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection by Andonegui, Graciela, Zhou, Hong, Bullard, Daniel, Kelly, Margaret M, Mullaly, Sarah C, McDonald, Braedon, Long, Elizabeth M, Robbins, Stephen M, Kubes, Paul

“…Recognition of LPS by TLR4 on immune sentinel cells such as macrophages is thought to be key to the recruitment of neutrophils to sites of infection with…”
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The Role of TLR2 In Vivo following Challenge with Staphylococcus aureus and Prototypic Ligands by Mullaly, Sarah C, Kubes, Paul

“…Based on a wealth of in vitro macrophage studies, immunity to Staphylococcus aureus cell wall-derived peptidoglycan (PGN) and lipoteichoic acid has been…”
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Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function by Lehnertz, Bernhard, Northrop, Jeffrey P, Antignano, Frann, Burrows, Kyle, Hadidi, Sima, Mullaly, Sarah C, Rossi, Fabio M V, Zaph, Colby

“…Accumulating evidence suggests that the regulation of gene expression by histone lysine methylation is crucial for several biological processes. The histone…”
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Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs by Andonegui, Graciela, Bonder, Claudine S, Green, Francis, Mullaly, Sarah C, Zbytnuik, Lori, Raharjo, Eko, Kubes, Paul

“…The rapid and selective accumulation of neutrophils into the lungs is thought to underlie the pulmonary failure that leads to sepsis-related death. In this…”
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Trichuris muris infection: a model of type 2 immunity and inflammation in the gut by Antignano, Frann, Mullaly, Sarah C, Burrows, Kyle, Zaph, Colby

“…Trichuris muris is a natural pathogen of mice and is biologically and antigenically similar to species of Trichuris that infect humans and livestock. Infective…”
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LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration by Liu, Lixin, Cara, Denise C, Kaur, Jaswinder, Raharjo, Eko, Mullaly, Sarah C, Jongstra-Bilen, Jenny, Jongstra, Jan, Kubes, Paul

“…Leukocyte-specific protein 1 (LSP1), an F-actin binding protein and a major downstream substrate of p38 mitogen-activated protein kinase as well as protein…”
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Stable lymphocyte contact induces remodeling of endothelial cell matrix receptor complexes by Mullaly, Sarah C., Moyse, Rebecca J., Nelson, Randal C., Murray, Allan G.

“…Endothelial cells (EC) actively participate in lymphocyte transendothelial migration by remodeling their actin cytoskeleton. We studied the endothelial cell…”
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Toll Gates and Traffic Arteries: From Endothelial TLR2 to Atherosclerosis by Mullaly, Sarah C, Kubes, Paul

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Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs by Andonegui, Graciela, Bonder, Claudine S., Green, Francis, Mullaly, Sarah C., Zbytnuik, Lori, Raharjo, Eko, Kubes, Paul

“…The rapid and selective accumulation of neutrophils into the lungs is thought to underlie the pulmonary failure that leads to sepsis-related death. In this…”
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Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut by Antignano, Frann, Mullaly, Sarah C., Burrows, Kyle, Zaph, Colby

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Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function by Lehnertz, Bernhard, Northrop, Jeffrey P., Antignano, Frann, Burrows, Kyle, Hadidi, Sima, Mullaly, Sarah C., Rossi, Fabio M.V., Zaph, Colby

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