Search Results - "Mulier, Kristine"

Evaluation of novel formulations of d-β-hydroxybutyrate and melatonin in a rat model of hemorrhagic shock by Wolf, Andrea, Thakral, Seema, Mulier, Kristine E., Suryanarayanan, Raj, Beilman, Gregory J

“…[Display omitted] d-β-hydroxybutyrate and melatonin (BHB/MLT) infusion improves survival in hemorrhagic shock models. The original BHB/MLT formulation contains…”
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Perioperative Coagulation Changes in Total Pancreatectomy and Islet Autotransplantation by Bergman, Zachary R., Robbins, Alexandria J., Alwan, Fatima S., Bellin, Melena D., Kirchner, Varvara A., Pruett, Timothy L., Mulier, Kristine E., Boucher, Alex A., Lusczek, Elizabeth R., Beilman, Greg J.

“…Objectives Thrombotic complications after total pancreatectomy with islet autotransplantation (TPIAT) are common. However, the systemic changes to coagulation…”
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Alterations in Enteroendocrine Hormones After Total Pancreatectomy With Islet Autotransplantation by McEachron, Kendall R., Yang, Yi, Hodges, James S., Beilman, Gregory J., Pruett, Timothy L., Kirchner, Varvara A., Dunn, Ty B., Freeman, Martin L., Trikudanathan, Guru, Mulier, Kristine E., Ptacek, Peggy, Bellin, Melena D.

“…When total pancreatectomy with islet autotransplantation (TPIAT) is performed for chronic pancreatitis, the pancreas and most of the duodenum are removed, with…”
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Dynamic near-infrared spectroscopy measurements in patients with severe sepsis by Skarda, David E, Mulier, Kristine E, Myers, Dean E, Taylor, Jodie H, Beilman, Greg J

“…This study evaluated near-infrared spectroscopy (NIRS)-derived measurements in hemodynamically stable patients with severe sepsis, as compared with similar…”
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A four-compartment metabolomics analysis of the liver, muscle, serum, and urine response to polytrauma with hemorrhagic shock following carbohydrate prefeed by Witowski, Nancy, Lusczek, Elizabeth, Determan, Jr, Charles, Lexcen, Daniel, Mulier, Kristine, Ostrowski, Beverly, Beilman, Greg

“…Hemorrhagic shock accompanied by injury represents a major physiologic stress. Fasted animals are often used to study hemorrhagic shock (with injury). A fasted…”
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D-β-Hydroxybutyrate and melatonin for treatment of porcine hemorrhagic shock and injury: a melatonin dose-ranging study by Wolf, Andrea, Mulier, Kristine E, Muratore, Sydne L, Beilman, Gregory J

“…Treatment with a combination of D-β-hydroxybutyrate (BHB) and melatonin (M) improves survival in hemorrhagic shock models. Our objective was to find the most…”
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Hypercoagulability in Porcine Hemorrhagic Shock is Present Early After Trauma and Resuscitation by Mulier, Kristine E., M.B.S, Greenberg, Joseph G., M.D, Beilman, Gregory J., M.D

“…Introduction The understanding of coagulopathy associated with trauma continues to evolve. Trauma patients are frequently coagulopathic early after injury and…”
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Low StO2 measurements in surgical intensive care unit patients is associated with poor outcomes by Iyegha, Uroghupatei P, Conway, Tyler, Pokorney, Kristin, Mulier, Kristine E, Nelson, Teresa R, Beilman, Greg J

“…Near-infrared spectroscopy-derived tissue hemoglobin saturation (StO2) is a noninvasive measurement that reflects changes in microcirculatory tissue perfusion…”
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Analysis of biomarkers characteristic of porcine liver injury--from biomolecular logic gates to an animal model by Halámková, Lenka, Halámek, Jan, Bocharova, Vera, Wolf, Steven, Mulier, Kristine E, Beilman, Greg, Wang, Joseph, Katz, Evgeny

“…A biocatalytic cascade for the analysis of the simultaneous increase in the concentration of two biomarkers characteristic of liver injury (alanine…”
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Metabolomics classifies phase of care and identifies risk for mortality in a porcine model of multiple injuries and hemorrhagic shock by Lexcen, Daniel R, Lusczek, Elizabeth R, Witowski, Nancy E, Mulier, Kristine E, Beilman, Greg J

“…Early recognition and intervention in hemorrhagic shock is essential to improved outcomes. However, the lack of robust diagnostic tools readily available to…”
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Treatment with beta-hydroxybutyrate and melatonin is associated with improved survival in a porcine model of hemorrhagic shock by Mulier, Kristine E, Lexcen, Daniel R, Luzcek, Elizabeth, Greenberg, Joseph J, Beilman, Gregory J

“…Abstract Introduction The neuroprotective ketone β-hydroxybutyrate (BHB) and the antioxidant melatonin have been found at elevated levels in hibernating…”
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Bovine serum albumin as a molecular sensor for the discrimination of complex metabolite samples by Hamerly, Timothy, Heinemann, Joshua, Tokmina-Lukaszewska, Monika, Lusczek, Elizabeth R., Mulier, Kristine E., Beilman, Greg J., Bothner, Brian

“…•Bovine serum albumin can be used as a molecular sensor to simplify complex samples.•The assay is rapid, robust, and enhances the ability to categorize complex…”
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Fed state prior to hemorrhagic shock and polytrauma in a porcine model results in altered liver transcriptomic response by Determan, Jr, Charles, Anderson, Rebecca, Becker, Aaron, Witowski, Nancy, Lusczek, Elizabeth, Mulier, Kristine, Beilman, Greg J

“…Hemorrhagic shock is a leading cause of trauma-related mortality in both civilian and military settings. Resuscitation often results in reperfusion injury and…”
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Safety of D-ß-Hydroxybutyrate and Melatonin for the Treatment of Hemorrhagic Shock With Polytrauma by Wolf, Andrea, Mulier, Kristine E, Iyegha, Uroghupatei P, Asghar, Javariah I, Beilman, Gregory J

“…ABSTRACTD-ß-hydroxybutyrate (BHB) and melatonin (M) treatment improves survival in animal models of hemorrhagic shock. Here, we evaluated the safety of BHB/M…”
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Urinary metabolic network analysis in trauma, hemorrhagic shock, and resuscitation by Lusczek, Elizabeth R., Lexcen, Daniel R., Witowski, Nancy E., Mulier, Kristine E., Beilman, Greg

“…Hemorrhagic shock, often a result of traumatic injury, is a condition of reduced perfusion that results in diminished delivery of oxygen to tissues. The…”
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Eight Hours of Hypotensive versus Normotensive Resuscitation in a Porcine Model of Controlled Hemorrhagic Shock by Skarda, David E., Mulier, Kristine E., George, Mark E., Beilman, Greg J.

“…Objectives:  The aim of this study was to compare hypotensive and normotensive resuscitation in a porcine model of hemorrhagic shock. Methods:  This was a…”
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Prolonged Induced Hypothermia in Hemorrhagic Shock Is Associated With Decreased Muscle Metabolism: A Nuclear Magnetic Resonance-Based Metabolomics Study by Lusczek, Elizabeth R, Lexcen, Daniel R, Witowski, Nancy E, Determan, Charles, Mulier, Kristine E, Beilman, Greg

“…ABSTRACTHemorrhagic shock is a leading cause of trauma-related death in war and is associated with significant alterations in metabolism. Using archived serum…”
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Liver Metabolomic Changes Identify Biochemical Pathways in Hemorrhagic Shock by Scribner, Drew M., M.S, Witowski, Nancy E., Ph.D, Mulier, Kristine E., M.S, Lusczek, Elizabeth R., M.S, Wasiluk, Karen R., Ph.D, Beilman, Greg J., M.D

“…Background Despite ongoing advances in treatment, thousands of patients still die annually from complications due to hemorrhagic shock, a condition causing…”
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Environmental hypothermia in porcine polytrauma and hemorrhagic shock is safe by Iyegha, Uroghupatei P, Greenberg, Joseph J, Mulier, Kristine E, Chipman, Jeffrey, George, Mark, Beilman, Greg J

“…We have previously demonstrated survival benefit to induced hypothermia in a porcine model of controlled hemorrhagic shock simulating an associated delay to…”
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Preinjury Fed State Alters the Physiologic Response in a Porcine Model of Hemorrhagic Shock and Polytrauma by Colling, Kristin P, Iyegha, Uroghupatei P, Asghar, Javariah I, Lexcen, Daniel R, Lusczek, Elizabeth R, Determan, Charles E, Witowski, Nancy E, Mulier, Kristine E, Beilman, Greg J

“…ABSTRACTIntroductionHemorrhagic shock and injury lead to dramatic changes in metabolic demands and continue to be a leading cause of death. We hypothesized…”
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