Search Results - "Mulford, J"

Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer by Raoof, Sana, Mulford, Iain J., Frisco-Cabanos, Heidie, Nangia, Varuna, Timonina, Daria, Labrot, Emma, Hafeez, Nafeeza, Bilton, Samantha J., Drier, Yotam, Ji, Fei, Greenberg, Max, Williams, August, Kattermann, Krystina, Damon, Leah, Sovath, Sosathya, Rakiec, Daniel P., Korn, Joshua M., Ruddy, David A., Benes, Cyril H., Hammerman, Peter S., Piotrowska, Zofia, Sequist, Lecia V., Niederst, Matthew J., Barretina, Jordi, Engelman, Jeffrey A., Hata, Aaron N.

“…Evolved resistance to tyrosine kinase inhibitor (TKI)-targeted therapies remains a major clinical challenge. In epidermal growth factor receptor ( EGFR )…”
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Clopidogrel Pharmacokinetics and Pharmacodynamics Vary Widely Despite Exclusion or Control of Polymorphisms ( CYP2C19 , ABCB1 , PON1 ), Noncompliance, Diet, Smoking, Co-Medications (Including Proton Pump Inhibitors), and Pre-Existent Variability in Platelet Function by Frelinger, Andrew L., PhD, Bhatt, Deepak L., MD, MPH, Lee, Ronald D., PhD, Mulford, Darcy J., PhD, Wu, Jingtao, PhD, Nudurupati, Sai, PhD, Nigam, Anu, MS, Lampa, Michael, BS, Brooks, Julie K., MS, Barnard, Marc R., MS, Michelson, Alan D., MD

“…Objectives This study sought to determine whether known genetic, drug, dietary, compliance, and lifestyle factors affecting clopidogrel absorption and…”
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A Population Pharmacokinetic Model of Vonoprazan: Evaluating the Effects of Race, Disease Status, and Other Covariates on Exposure by Scarpignato, Carmelo, Leifke, Eckhard, Smith, Neila, Mulford, Darcy J., Lahu, Gezim, Facius, Axel, Howden, Colin W.

“…Vonoprazan, a potassium‐competitive acid blocker, is under investigation in the United States and Europe for the treatment of erosive esophagitis and…”
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A Randomized, 2-Period, Crossover Design Study to Assess the Effects of Dexlansoprazole, Lansoprazole, Esomeprazole, and Omeprazole on the Steady-State Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Volunteers by Frelinger, Andrew L., PhD, Lee, Ronald D., PhD, Mulford, Darcy J., PhD, Wu, Jingtao, PhD, Nudurupati, Sai, PhD, Nigam, Anu, MS, Brooks, Julie K., MS, Bhatt, Deepak L., MD, MPH, Michelson, Alan D., MD

“…Objectives The aim of this study was to assess the effects of different proton pump inhibitors (PPIs) on the steady-state pharmacokinetics and pharmacodynamics…”
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Proximal Row Carpectomy vs Four Corner Fusion for Scapholunate (Slac) or Scaphoid Nonunion Advanced Collapse (Snac) Wrists: A Systematic Review of Outcomes by MULFORD, J. S., CEULEMANS, L. J., NAM, D., AXELROD, T. S.

“…Proximal row carpectomy (PRC) and scaphoid excision with four-corner fusion (4CF) are common motion-preserving, salvage procedures for the treatment of wrists…”
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Protein prediction for trait mapping in diverse populations by Schubert, Ryan, Geoffroy, Elyse, Gregga, Isabelle, Mulford, Ashley J, Aguet, Francois, Ardlie, Kristin, Gerszten, Robert, Clish, Clary, Van Den Berg, David, Taylor, Kent D, Durda, Peter, Johnson, W Craig, Cornell, Elaine, Guo, Xiuqing, Liu, Yongmei, Tracy, Russell, Conomos, Matthew, Blackwell, Tom, Papanicolaou, George, Lappalainen, Tuuli, Mikhaylova, Anna V, Thornton, Timothy A, Cho, Michael H, Gignoux, Christopher R, Lange, Leslie, Lange, Ethan, Rich, Stephen S, Rotter, Jerome I, Manichaikul, Ani, Im, Hae Kyung, Wheeler, Heather E

“…Genetically regulated gene expression has helped elucidate the biological mechanisms underlying complex traits. Improved high-throughput technology allows…”
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Metabolism and Excretion of [14C] Febuxostat, a Novel Nonpurine Selective Inhibitor of Xanthine Oxidase, in Healthy Male Subjects by Grabowski, Brian A., Khosravan, Reza, Vernillet, Laurent, Mulford, Darcy J.

“…Absorption, metabolism, and excretion of one 80 mg oral dose of [14C] febuxostat ([thiazole‐4‐14C] 2‐[3‐cyano‐4‐isobutoxyphenyl]‐4‐methyl‐5‐thiazolecarboxylic…”
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Tiered approach to evaluate the CYP3A victim and perpetrator drug–drug interaction potential for vonoprazan using PBPK modeling and clinical data to inform labeling by Mulford, Darcy J., Ramsden, Diane, Zhang, Liming, Michon, Ingrid, Leifke, Eckhard, Smith, Neila, Jones, Hannah M., Scarpignato, Carmelo

“…Vonoprazan is metabolized extensively through CYP3A and is an in vitro time‐dependent inhibitor of CYP3A. A tiered approach was applied to understand the CYP3A…”
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Recreational off-highway vehicle exposure, safety behaviors and crash experiences among adolescents by Jennissen, Charles A, Schaeffer, Sienna E, Hoogerwerf, Pamela J, Wetjen, Kristel M, Mulford, Lauren J, Champoux, Katharine L, Okoro, Uche E, Denning, Gerene M

“…Recreational off-highway vehicles (ROVs), often called utility task vehicles (UTVs), are designed to be driven by those ≥ 16 years and manufacturers recommend…”
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All-terrain vehicle exposure and the association of certified training on adolescent safety behaviors and crash experiences by Jennissen, Charles A, Champoux, Katharine L, Hoogerwerf, Pamela J, Wetjen, Kristel M, Mulford, Lauren J, Schaeffer, Sienna E, Okoro, Uche E, Denning, Gerene M

“…Certified training courses in all-terrain vehicle (ATV) operation are recommended, but little has been published regarding how they affect riding behaviors…”
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Pharmacodynamics and Pharmacokinetics of the Potassium-Competitive Acid Blocker Vonoprazan and the Proton Pump Inhibitor Lansoprazole in US Subjects by Laine, Loren, Sharma, Prateek, Mulford, Darcy J., Hunt, Barbara, Leifke, Eckhard, Smith, Neila, Howden, Colin W.

“…We assessed pharmacodynamics and pharmacokinetics of a potassium-competitive acid blocker and proton pump inhibitor in U.S. subjects. Healthy adults were…”
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S524 Bioequivalence of Vonoprazan Sprinkle Capsule and Vonoprazan Tablet in Healthy Subjects by Chang, Yu-Ming, Leifke, Eckhard, Smith, Neila, Witt, Galen, Mulford, Darcy J.

“…Methods: In this phase 1, single-dose, open-label, randomized, 3-period, 3-sequence crossover study, the bioavailability of a 20 mg vonoprazan sprinkle…”
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Genetically regulated expression underlies cellular sensitivity to chemotherapy in diverse populations by Mulford, Ashley J, Wing, Claudia, Dolan, M Eileen, Wheeler, Heather E

“…Abstract Most cancer chemotherapeutic agents are ineffective in a subset of patients; thus, it is important to consider the role of genetic variation in drug…”
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A translational pharmacokinetic/pharmacodynamic approach supports optimal vonoprazan dosing for erosive oesophagitis and Helicobacter pylori infection by Scarpignato, Carmelo, Howden, Colin W., Leifke, Eckhard, Mulford, Darcy J., Lahu, Gezim, Facius, Axel, Hunt, Richard

“…Summary Background Treatment of acid‐related disorders relies on gastric acid suppression. The percentage of time intragastric pH is >4 (pH >4 holding time…”
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The Effect of Food on the Pharmacokinetics of the Potassium‐Competitive Acid Blocker Vonoprazan by Mulford, Darcy J., Leifke, Eckhard, Hibberd, Mark, Howden, Colin W.

“…Herein, we report a food‐effect study of vonoprazan, an oral potassium‐competitive acid blocker. In a phase 1, randomized, open‐label, crossover study, healthy…”
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Response to Graham by Laine, Loren, Sharma, Prateek, Mulford, Darcy J., Hunt, Barbara, Leifke, Eckhard, Smith, Neila, Howden, Colin W.

“…Dr. Graham requests additional information regarding the protocol of our study comparing the pharmacodynamics of the potassium-competitive blocker, vonoprazan,…”
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Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment by Wang, Hui Qin, Mulford, Iain J., Sharp, Fiona, Liang, Jinsheng, Kurtulus, Sema, Trabucco, Gina, Quinn, David S., Longmire, Tyler A., Patel, Nidhi, Patil, Roshani, Shirley, Matthew D., Chen, Yan, Wang, Hao, Ruddy, David A., Fabre, Claire, Williams, Juliet A., Hammerman, Peter S., Mataraza, Jennifer, Platzer, Barbara, Halilovic, Ensar

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A prospective evaluation of trochleoplasty for the treatment of patellofemoral dislocation and instability by UTTING, M. R, MULFORD, J. S, ELDRIDGE, J. D. J

“…Trochlear dysplasia is a developmental condition characterised by an abnormally flat or dome-shaped trochlea and is an important contributory factor to…”
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Benjamin Franklin and Women: Or, Franklin's Women by Mulford, Carla J.

“…Reappraising Benjamin Franklin in the context of the politics of his day, this article examines how his supposed questionable reputation with women dates to…”
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Comparative pharmacokinetics and safety of lansoprazole oral capsules and orally disintegrating tablets in healthy subjects by Freston, J. W., Chiu, Y.‐L., Mulford, D. J., Ballard II, E. D.

“…Summary Background : Many individuals with acid‐related gastrointestinal disorders have difficulty in swallowing oral agents. Aim : To compare the…”
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