Search Results - "Mulford, D J"

Comparative pharmacokinetics and safety of lansoprazole oral capsules and orally disintegrating tablets in healthy subjects by Freston, J. W., Chiu, Y.‐L., Mulford, D. J., Ballard II, E. D.

“…Summary Background : Many individuals with acid‐related gastrointestinal disorders have difficulty in swallowing oral agents. Aim : To compare the…”
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Oxidative metabolism of clarithromycin in the presence of human liver microsomes : Major role for the cytochrome P4503A (CYP3A) subfamily by RODRIGUES, A. D, ROBERTS, E. M, MULFORD, D. J, YAO, Y, OUELLET, D

“…In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) protein(s) involved in the oxidative metabolism of [14C]clarithromycin (CLAR) in…”
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In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P4503A4 and NADPH-P450 reductase. Comparison to human liver microsomes and precision-cut liver tissue slices by Rodrigues, A D, Mulford, D J, Lee, R D, Surber, B W, Kukulka, M J, Ferrero, J L, Thomas, S B, Shet, M S, Estabrook, R W

“…The metabolism of terfenadine was studied with a cDNA-expressed/purified recombinant fusion protein containing human liver microsomal cytochrome P4503A4…”
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Stereoselective pharmacokinetics of pazinaclone, a new non‐benzodiazepine anxiolytic, and its active metabolite in healthy subjects by HUSSEIN, Z., MULFORD, D. J., BOPP, B. A., GRANNEMAN, G. R.

“…1 Serum and urine concentrations of enantiomers of pazinaclone (DN‐2327) and an active metabolite MII, were measured after single and twice daily oral doses of…”
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Metabolism of sertindole: identification of the metabolites in the rat and dog, and species comparison of liver microsomal metabolism by Sakamoto, K, Nakamura, Y, Aikoh, S, Baba, T, Perregaard, J, Pedersen, H, Moltzen, E K, Mulford, D J, Yamaguchi, T

“…1. The main exretion pathways of a novel antipsychotic drug, sertindole, in the rat and dog are faecal excretion via intestinal secretion and biliary excretion…”
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Differences in the stereoselective pharmacokinetics of pazinaclone (DN-2327), a new anxiolytic, and its active metabolite after intravenous and oral single doses to dogs by Hussein, Z, Mulford, D J, Bopp, B A, Granneman, G R

“…The stereoselective pharmacokinetics of the new nonbenzodiazepine anxiolytic compound pazinaclone (DN-2327) were studied in four beagle dogs after oral (2.5…”
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Metabolism of 1,2,4-trichlorobenzene in rats: examination of thiol formation by Bakke, J E, Huwe, J K, Mulford, D J, Bergman, A

“…1. More than 60% of oral doses of 14C-1,2,4-trichlorobenzene (ca. 21 mg/kg) administered to rats were excreted in bile as S-trichlorophenyl-mercapturic acid…”
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Studies on the displacement of methylthio groups by glutathione by Huwe, J K, Feil, V J, Bakke, J E, Mulford, D J

“…1. 14C-Methylthio-labelled 2-methylthio-4-ethylamino-6-tert-butylamino-sym-triazine (terbutryn), pentachlorothioanisole (PCTA), and…”
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Synthesis and Antifungal Activity of 1,3,2-Benzodithiazole S-Oxides by Klein, Larry L, Yeung, Clinton M, Weissing, David E, Lartey, Paul A, Tanaka, S. Ken, Plattner, Jacob J, Mulford, Darcy J

“…The preparation of 1,3,2-benzodithiazole S-oxide analogs exhibiting in vitro antifungal activity against several strains of Candida is described. For the…”
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Biliary excretion and intestinal metabolism in the intermediary metabolism of pentachlorothioanisole by Bakke, J E, Feil, V J, Mulford, D J

“…1. Biliary metabolites from rats dosed with pentachlorothioanisole (PCTA) were characterized by fast atom bombardment mass spectrometry and electron impact…”
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Glutathione-mediated methylthio-turnover and sex differences in the metabolism of pentachlorothioanisole by rat by Bakke, J E, Mulford, D J, Huwe, J K, Feil, V J, Davison, K L

“…1. Sex differences observed in the metabolism of pentachlorothioanisole in rat were due to: (1) greater excretion in urine by females, and greater biliary…”
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Glutathione-S-transferase-mediated methylthio displacement and turnover in the metabolism of pentachlorothioanisole by rats by Mulford, D J, Bakke, J E, Feil, V J

“…1. The metabolism of pentachlorothioanisole to bis-(methylthio)tetrachlorobenzene was shown to involve turnover of about 50% of the original methylthio group…”
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Derivatives of blood plasma by MULFORD, D J

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Assay of TNP-470 and Its Two Major Metabolites in Human Plasma by High-Performance Liquid Chromatography-Mass Spectrometry by Whalen, Carl T., Hanson, Glenn D., Putzer, Kathy J., Mayer, Michael D., Mulford, Darcy J.

“…In this study, a sensitive, specific assay for the determination of TNP-470 and its two major metabolites M-IV (also know as AGM-1883) and M-II in human plasma…”
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Diet of adult female rats and relation to kidney lesions in choline deficient offspring by MULFORD, D J

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Heat stability of protein solutions obtained from human plasma by different ethanol concentrations and temperatures by MEALEY, E H, MULFORD, D J

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Amino alcohols and methyl donors in rats fed low choline diets containing added cholesterol by Chaplin, M D, Mulford, D J

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The effect of 2-amino-2-methylpropanol on rat liver phospholipid metabolism by LONGMORE, W J, MULFORD, D J

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The effect of 2-amino-2-methyl-1-propanol on the incidence of kidney lesions in male rats of different ages fed diets low in choline by MULFORD, D J, OUTLAND, C E

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EFFECT OF 3-AMINOPROPANOL ON CHOLINE-DEFICIENCY IN RATS by HUME, J W, MULFORD, D J, RUSSELL, P J

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