Search Results - "Mule, JJ"

Comparative analysis of necrotic and apoptotic tumor cells as a source of antigen(s) in dendritic cell-based immunization by KOTERA, Yoshihito, SHIMIZU, Koichi, MULE, James J

“…There is considerable controversy as to whether necrotic (lysate) or apoptotic tumor cells serve as the superior source of multiple tumor-associated antigens…”
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Tumor Lysate-Pulsed Dendritic Cells Can Elicit an Effective Antitumor Immune Response during Early Lymphoid Recovery by Asavaroengchai, W., Kotera, Y., Mulé, J. J.

“…Dendritic cells (DC) can serve to immunize the newborn immune system to foreign antigen. In a lymphopenic environment, naive T cells undergoing…”
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Murine Dendritic Cells Pulsed with Whole Tumor Lysates Mediate Potent Antitumor Immune Responses in vitro and in vivo by Fields, R. C., Shimizu, K., Mule, J. J.

“…The highly efficient nature of dendritic cells (DC) as antigen-presenting cells raises the possibility of uncovering in tumor-bearing hosts very low levels of…”
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Hematopoietic Potential of Cryopreserved and Ex Vivo Manipulated Umbilical Cord Blood Progenitor Cells Evaluated In Vitro and In Vivo by DiGiusto, David L., Lee, Robert, Moon, James, Moss, Katherine, O'Toole, Tom, Voytovich, Amy, Webster, Donna, Mule, James J.

“…The hematopoietic potential of cryopreserved and ex vivo manipulated umbilical cord blood (UCB) samples was evaluated in vitro and in vivo. Phenotypic analysis…”
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Vaccination of pediatric solid tumor patients with tumor lysate-pulsed dendritic cells can expand specific T cells and mediate tumor regression by GEIGER, James D, HUTCHINSON, Raymond J, HOHENKIRK, Lyndon F, MCKENNA, Elizabeth A, YANIK, Gregory A, LEVINE, John E, CHANG, Alfred E, BRAUN, Thomas M, MULE, James J

“…Dendritic cells (DCs) have been shown to be a promising adjuvant for inducing immunity to cancer. We evaluated tumor lysate-pulsed DC in a Phase I trial of…”
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Allogeneic and Autologous Melanoma Vaccines: Where Have We Been and Where Are We Going? by Sondak, Vernon K, Sabel, Michael S, Mulé, James J

“…The past three decades have seen substantial research on vaccines for the treatment of metastatic melanoma and the prevention of recurrence following…”
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A Phase I Trial of Tumor Lysate-pulsed Dendritic Cells in the Treatment of Advanced Cancer by CHANG, Alfred E, REDMAN, Bruce G, WHITFIELD, Joel R, NICKOLOFF, Brian J, BRAUN, Thomas M, LEE, Peter P, GEIGER, James D, MULE, James J

“…Purpose: The objectives of this study were to assess the toxicity and immunologicalresponse induced by the intradermal (i.d) administration of tumor…”
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Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis by Morita, Y, Yang, J, Gupta, R, Shimizu, K, Shelden, E A, Endres, J, Mulé, J J, McDonagh, K T, Fox, D A

“…Dendritic cells (DCs) are specialized antigen-presenting cells that migrate from the periphery to lymphoid tissues, where they activate and regulate T cells…”
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The dynamics of the T-cell antitumor response: Chemokine-secreting dendritic cells can prime tumor-reactive T cells extranodally by KIRK, Christopher J, HARTIGAN-O'CONNOR, Dennis, MULE, James J

“…Direct administration of dendritic cells (DCs) genetically modified to express secondary lymphoid tissue chemokine (SLC) into growing B16 melanoma could result…”
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Current developments of immunotherapy in the clinic by Antonia, Scott, Mulé, James J, Weber, Jeffrey S

“…The clinical application of immunotherapy for cancer is rapidly moving forward in multiple areas, including the adoptive transfer of anti-tumor-reactive T…”
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T cell-dependent antitumor immunity mediated by secondary lymphoid tissue chemokine : Augmentation of dendritic cell-based immunotherapy by KIRK, Christopher J, HARTIGAN-O'CONNOR, Dennis, NICKOLOFF, Brian J, CHAMBERLAIN, Jeffrey S, GIEDLIN, Martin, AUKERMAN, Lea, MULE, James J

“…Secondary lymphoid tissue chemokine (SLC) is a CC chemokine that is selective in its recruitment of naive T cells and dendritic cells (DCs). In the lymph node,…”
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Gene-modified dendritic cells for use in tumor vaccines by Kirk, C J, Mulé, J J

“…Dendritic cells (DCs) are potent antigen-presenting cells capable of priming activation of naive T cells. Because of their immunostimulatory capacity,…”
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Enhancement of tumor lysate- and peptide-pulsed dendritic cell-based vaccines by the addition of foreign helper protein by SHIMIZU, Koichi, THOMAS, Elaine K, GIEDLIN, Martin, MULE, James J

“…We have evaluated whether the addition of a foreign helper protein, keyhole limpet hemocyanin (KLH), can augment the efficacy of tumor lysate-pulsed dendritic…”
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Systemic Administration of Interleukin 2 Enhances the Therapeutic Efficacy of Dendritic Cell-Based Tumor Vaccines by Shimizu, K., Fields, R. C., Giedlin, M., Mule, J. J.

“…We have reported previously that murine bone marrow-derived dendritic cells (DC) pulsed with whole tumor lysates can mediate potent antitumor immune responses…”
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Local administration of dendritic cells inhibits established breast tumor growth : Implications for apoptosis-inducing agents by CANDIDO, Kimberly A, SHIMIZU, Koichi, MCLAUGHLIN, Julie C, KUNKEL, Robin, FULLER, Jennifer A, REDMAN, Bruce G, THOMAS, Elaine K, NICKOLOFF, Brian J, MULE, James J

“…Dendritic cells (DCs) can efficiently acquire foreign antigen(s) from apoptotic cells and induce MHC class I-restricted, antigen-specific CTLs. An accumulation…”
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Immune Evasion by Muscle-Specific Gene Expression in Dystrophic Muscle by Hartigan-O'Connor, Dennis, Kirk, Christopher J., Crawford, Robert, Mulé, James J., Chamberlain, Jeffrey S.

“…Muscle tissue from Duchenne muscular dystrophy patients and the Dmdmdx/mdx (hereafter referred to as mdx) mouse is characterized by an abundance of necrotic…”
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Immunostimulatory effects of CpG-ODN upon dendritic cell-based immunotherapy in a murine melanoma model by Pilon-Thomas, Shari, Li, Wenbin, Briggs, Jon J, Djeu, Julie, Mulé, James J, Riker, Adam I

“…In this study, we examined the protective and therapeutic efficacy of the immunoadjuvant CpG in combination with dendritic cell (DC) immunotherapy in a murine…”
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Inducible Expression of Macrophage Receptor Marco by Dendritic Cells Following Phagocytic Uptake of Dead Cells Uncovered by Oligonucleotide Arrays by Grolleau, Annabelle, Misek, David E, Kuick, Rork, Hanash, Samir, Mule, James J

“…The efficient Ag presenting and immunostimulatory capacity of dendritic cells (DCs) has led to the use of tumor Ag-pulsed DCs in treatment regimens for cancer…”
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Experimental and clinical studies of cytokine gene-modified tumor cells by Tepper, R I, Mulé, J J

“…Cytokines are key modulators of host immune and inflammatory responses. The expression of cytokine genes by tumor cells as a result of gene transfer has…”
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Identification of human cancers deficient in antigen processing by RESTIFO, N. P, ESQUIVEL, F, KAWAKAMI, Y, YEWDELL, J. W, MULE, J. J, ROSENBERG, S. A, BENNINK, J. R

“…Intracellular antigens must be processed before presentation to CD8+ T cells by major histocompatibility complex (MHC) class I molecules. Using a recombinant…”
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