Search Results - "Mulder, Tessa A. M."

Factors affecting inter-individual variability in endoxifen concentrations in patients with breast cancer: results from the prospective TOTAM trial by Braal, C. Louwrens, Westenberg, Justin D., Buijs, Sanne M., Abrams, Steven, Mulder, Tessa A. M., van Schaik, Ron H. N., Koolen, Stijn L. W., Jager, Agnes, Mathijssen, Ron H. J.

“…Introduction Endoxifen—the principal metabolite of tamoxifen—is subject to a high inter-individual variability in serum concentration. Numerous attempts have…”
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CYP3A4∗22 Genotyping in Clinical Practice: Ready for Implementation? by Mulder, Tessa A. M., van Eerden, Ruben A. G., de With, Mirjam, Elens, Laure, Hesselink, Dennis A., Matic, Maja, Bins, Sander, Mathijssen, Ron H. J., van Schaik, Ron H. N.

“…Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the liver, responsible for the oxidative metabolism of ∼50% of clinically…”
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Interferon-gamma induces epithelial reprogramming driving CXCL11-mediated T-cell migration by Cutilli, Alessandro, Jansen, Suze A, Paolucci, Francesca, van Hoesel, Marliek, Frederiks, Cynthia L, Mulder, Tessa A M, Chalkiadakis, Theofilos, Mokry, Michal, Prekovic, Stefan, Mocholi, Enric, Lindemans, Caroline A, Coffer, Paul J

“…Abstract The cytokine interferon-gamma plays a multifaceted role in intestinal immune responses ranging from anti- to proinflammatory depending on the setting…”
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Clinical CYP2D6 Genotyping to Personalize Adjuvant Tamoxifen Treatment in ER-Positive Breast Cancer Patients: Current Status of a Controversy by Mulder, Tessa A M, de With, Mirjam, Del Re, Marzia, Danesi, Romano, Mathijssen, Ron H J, van Schaik, Ron H N

“…Tamoxifen is a major option for adjuvant endocrine treatment in estrogen receptor (ER) positive breast cancer patients. The conversion of the prodrug tamoxifen…”
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Capecitabine-induced hand-foot syndrome: A pharmacogenetic study beyond DPYD by de With, Mirjam, van Doorn, Leni, Maasland, Demi C., Mulder, Tessa A.M., Oomen-de Hoop, Esther, Mostert, Bianca, Homs, Marjolein Y.V., El Bouazzaoui, Samira, Mathijssen, Ron H.J., van Schaik, Ron H.N., Bins, Sander

“…Occurrence of hand-foot syndrome (HFS) during capecitabine treatment often results in treatment interruptions (26 %) or treatment discontinuation (17 %), and…”
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IFNγ induces epithelial reprogramming driving CXCL11-mediated T cell migration by Cutilli, Alessandro, Jansen, Suze A, Paolucci, Francesca, van Hoesel, Marliek, Fredericks, Cynthia L, Mulder, Tessa A M, Chalkiadakis, Theofilos, Mokry, Michal, Prekovic, Stefan, Mocholi, Enric, Lindemans, Caroline A, Coffer, Paul J

“…The cytokine interferon-gamma (IFNγ) plays a multifaceted role in intestinal immune responses ranging from anti- to pro-inflammatory depending on the setting…”
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