Search Results - "Mulder, Frans A.A"

Using NMR chemical shifts to calculate the propensity for structural order and disorder in proteins by Tamiola, Kamil, Mulder, Frans A A

“…NMR spectroscopy offers the unique possibility to relate the structural propensities of disordered proteins and loop segments of folded peptides to biological…”
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Contemporary NMR Studies of Protein Electrostatics by Hass, Mathias A.S, Mulder, Frans A.A

“…Electrostatics play an important role in many aspects of protein chemistry. However, the accurate determination of side chain proton affinity in proteins by…”
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Cavity as a Source of Conformational Fluctuation and High-Energy State: High-Pressure NMR Study of a Cavity-Enlarged Mutant of T4Lysozyme by Maeno, Akihiro, Sindhikara, Daniel, Hirata, Fumio, Otten, Renee, Dahlquist, Frederick W., Yokoyama, Shigeyuki, Akasaka, Kazuyuki, Mulder, Frans A.A., Kitahara, Ryo

“…Although the structure, function, conformational dynamics, and controlled thermodynamics of proteins are manifested by their corresponding amino acid…”
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Studying excited states of proteins by NMR spectroscopy by Kay, Lewis E, Mulder, Frans A.A, Mittermaier, Anthony, Hon, Bin, Dahlquist, Frederick W

“…Protein structure is inherently dynamic, with function often predicated on excursions from low to higher energy conformations. For example, X-ray studies of a…”
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The solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type fold by Hong, Zebin, Nowakowski, Michal, Spronk, Chris, Petersen, Steen V, Andreasen, Peter A, Koźmiński, Wiktor, Mulder, Frans A A, Jensen, Jan K

“…A decade ago, motif at N-terminus with eight-cysteines (MANEC) was defined as a new protein domain family. This domain is found exclusively at the N-terminus…”
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Latent and active p53 are identical in conformation by Ayed, Ayeda, Mulder, Frans A.A, Yi, Gwan-Su, Lu, Ying, Kay, Lewis E, Arrowsmith, Cheryl H

“…p53 is a nuclear phosphoprotein that regulates cellular fate after genotoxic stress through its role as a transcriptional regulator of genes involved in cell…”
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Fast and Quantitative NMR Metabolite Analysis Afforded by a Paramagnetic Co‐Solute by Mulder, Frans A. A., Tenori, Leonardo, Luchinat, Claudio

“…NMR spectroscopy is an indispensable technique for the determination of the chemical identity and structure of small molecules. The method is especially…”
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Comprehensive Determination of Protein Tyrosine pKa Values for Photoactive Yellow Protein Using Indirect 13C NMR Spectroscopy by Oktaviani, Nur Alia, Pool, Trijntje J., Kamikubo, Hironari, Slager, Jelle, Scheek, Ruud M., Kataoka, Mikio, Mulder, Frans A.A.

“…Upon blue-light irradiation, the bacterium Halorhodospira halophila is able to modulate the activity of its flagellar motor and thereby evade potentially…”
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Accurate Methyl Group Dynamics in Protein Simulations with AMBER Force Fields by Hoffmann, Falk, Mulder, Frans A. A, Schäfer, Lars V

“…An approach is presented to directly simulate the dynamics of methyl groups in protein side-chains, as accessible via NMR spin relaxation measurements, by…”
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Narrowing the gap between experimental and computational determination of methyl group dynamics in proteins by Hoffmann, Falk, Xue, Mengjun, Schäfer, Lars V, Mulder, Frans A A

“…Nuclear magnetic resonance (NMR) spin relaxation has become the mainstay technique to sample protein dynamics at atomic resolution, expanding its repertoire…”
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Unambiguous Determination of Protein Arginine Ionization States in Solution by NMR Spectroscopy by Yoshimura, Yuichi, Oktaviani, Nur Alia, Yonezawa, Kento, Kamikubo, Hironari, Mulder, Frans A. A.

“…Because arginine residues in proteins are expected to be in their protonated form almost without exception, reports demonstrating that a protein arginine…”
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Measurement of Very Fast Exchange Rates of Individual Amide Protons in Proteins by NMR Spectroscopy by Dass, Rupashree, Corlianò, Enrico, Mulder, Frans A. A.

“…NMR spectroscopy is a pivotal technique to measure hydrogen exchange rates in proteins. However, currently available NMR methods to measure backbone exchange…”
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Active-Site pKa Determination for Photoactive Yellow Protein Rationalizes Slow Ground-State Recovery by Oktaviani, Nur Alia, Pool, Trijntje J., Yoshimura, Yuichi, Kamikubo, Hironari, Scheek, Ruud M., Kataoka, Mikio, Mulder, Frans A.A.

“…The ability to avoid blue-light radiation is crucial for bacteria to survive. In Halorhodospira halophila, the putative receptor for this response is known as…”
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The Ribosomal Stalk Binds to Translation Factors IF2, EF-Tu, EF-G and RF3 via a Conserved Region of the L12 C-terminal Domain by Helgstrand, Magnus, Mandava, Chandra S., Mulder, Frans A.A., Liljas, Anders, Sanyal, Suparna, Akke, Mikael

“…Efficient protein synthesis in bacteria requires initiation factor 2 (IF2), elongation factors Tu (EF-Tu) and G (EF-G), and release factor 3 (RF3), each of…”
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There is Diversity in Disorder-"In all Chaos there is a Cosmos, in all Disorder a Secret Order" by Nielsen, Jakob T, Mulder, Frans A A

“…The protein universe consists of a continuum of structures ranging from full order to complete disorder. As the structured part of the proteome has been…”
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Aspartate buffer and divalent metal ions affect oxytocin in aqueous solution and protect it from degradation by Avanti, Christina, Oktaviani, Nur Alia, Hinrichs, Wouter L.J., Frijlink, Henderik W., Mulder, Frans A.A.

“…Oxytocin is a peptide drug used to induce labor and prevent bleeding after childbirth. Due to its instability, transport and storage of oxytocin formulations…”
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Bicyclic Peptide Inhibitor of Urokinase-Type Plasminogen Activator: Mode of Action by Roodbeen, Renée, Paaske, Berit, Jiang, Longguang, Jensen, Jan K., Christensen, Anni, Nielsen, Jakob T., Huang, Mingdong, Mulder, Frans A. A., Nielsen, Niels Chr, Andreasen, Peter A., Jensen, Knud J.

“…The development of protease inhibitors for pharmacological intervention has taken a new turn with the use of peptide‐based inhibitors. Here, we report the…”
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pKa Values for Side-Chain Carboxyl Groups of a PGB1 Variant Explain Salt and pH-Dependent Stability by Lindman, Stina, Linse, Sara, Mulder, Frans A.A., André, Ingemar

“…Determination of pK a values of titrating residues in proteins provides a direct means of studying electrostatic coupling as well as pH-dependent stability…”
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Biophysical Characterization of the Unstructured Cytoplasmic Domain of the Human Neuronal Adhesion Protein Neuroligin 3 by Paz, Aviv, Zeev-Ben-Mordehai, Tzviya, Lundqvist, Martin, Sherman, Eilon, Mylonas, Efstratios, Weiner, Lev, Haran, Gilad, Svergun, Dmitri I., Mulder, Frans A.A., Sussman, Joel L., Silman, Israel

“…Cholinesterase-like adhesion molecules (CLAMs) are a family of neuronal cell adhesion molecules with important roles in synaptogenesis, and in maintaining…”
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An Off-resonance Rotating Frame Relaxation Experiment for the Investigation of Macromolecular Dynamics Using Adiabatic Rotations by Mulder, Frans A.A., de Graaf, Robin A., Kaptein, Robert, Boelens, Rolf

“…15N off-resonance rotating frame relaxation can be applied to the study of internal dynamics in proteins in the millisecond to microsecond regime. We show that…”
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