Search Results - "Mulder, David T."

Type VI Secretion System-Associated Gene Clusters Contribute to Pathogenesis of Salmonella enterica Serovar Typhimurium by Mulder, David T, Cooper, Colin A, Coombes, Brian K

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GogB is an anti-inflammatory effector that limits tissue damage during Salmonella infection through interaction with human FBXO22 and Skp1 by Pilar, Ana Victoria C, Reid-Yu, Sarah A, Cooper, Colin A, Mulder, David T, Coombes, Brian K

“…Bacterial pathogens often manipulate host immune pathways to establish acute and chronic infection. Many Gram-negative bacteria do this by secreting effector…”
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Regulatory Evolution Drives Evasion of Host Inflammasomes by Salmonella Typhimurium by Ilyas, Bushra, Mulder, David T., Little, Dustin J., Elhenawy, Wael, Banda, María M., Pérez-Morales, Deyanira, Tsai, Caressa N., Chau, N.Y.E., Bustamante, Víctor H., Coombes, Brian K.

“…Bacterial two-component regulatory systems (TCS) couple the detection of niche-specific cues with adaptive gene expression to optimize fitness. In Salmonella…”
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Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours by Nabbi, Arash, Beck, Pengbo, Delaidelli, Alberto, Oldridge, Derek A., Sudhaman, Sumedha, Zhu, Kelsey, Yang, S. Y. Cindy, Mulder, David T., Bruce, Jeffrey P., Paulson, Joseph N., Raman, Pichai, Zhu, Yuankun, Resnick, Adam C., Sorensen, Poul H., Sill, Martin, Brabetz, Sebastian, Lambo, Sander, Malkin, David, Johann, Pascal D., Kool, Marcel, Jones, David T. W., Pfister, Stefan M., Jäger, Natalie, Pugh, Trevor J.

“…Background Cancer immunotherapies including immune checkpoint inhibitors and Chimeric Antigen Receptor (CAR) T-cell therapy have shown variable response rates…”
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Identification of the regulatory logic controlling Salmonella pathoadaptation by the SsrA-SsrB two-component system by Tomljenovic-Berube, Ana M, Mulder, David T, Whiteside, Matthew D, Brinkman, Fiona S L, Coombes, Brian K

“…Sequence data from the past decade has laid bare the significance of horizontal gene transfer in creating genetic diversity in the bacterial world. Regulatory…”
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Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma by Murata, Kenji, Nakatsugawa, Munehide, Rahman, Muhammed A, Nguyen, Linh T, Millar, Douglas G, Mulder, David T, Sugata, Kenji, Saijo, Hiroshi, Matsunaga, Yukiko, Kagoya, Yuki, Guo, Tingxi, Anczurowski, Mark, Wang, Chung-Hsi, Burt, Brian D, Ly, Dalam, Saso, Kayoko, Easson, Alexandra, Goldstein, David P, Reedijk, Michael, Ghazarian, Danny, Pugh, Trevor J, Butler, Marcus O, Mak, Tak W, Ohashi, Pamela S, Hirano, Naoto

“…HLA-restricted T cell responses can induce antitumor effects in cancer patients. Previous human T cell research has largely focused on the few HLA alleles…”
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Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function by Osborne, Suzanne E, Walthers, Don, Tomljenovic, Ana M, Mulder, David T, Silphaduang, Uma, Duong, Nancy, Lowden, Michael J, Wickham, Mark E, Waller, Ross F, Kenney, Linda J, Coombes, Brian K

“…The acquisition of DNA by horizontal gene transfer enables bacteria to adapt to previously unexploited ecological niches. Although horizontal gene transfer and…”
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Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase II Trial by Uppaluri, Ravindra, Campbell, Katie M, Egloff, Ann Marie, Zolkind, Paul, Skidmore, Zachary L, Nussenbaum, Brian, Paniello, Randal C, Rich, Jason T, Jackson, Ryan, Pipkorn, Patrik, Michel, Loren S, Ley, Jessica, Oppelt, Peter, Dunn, Gavin P, Barnell, Erica K, Spies, Nicholas C, Lin, Tianxiang, Li, Tiantian, Mulder, David T, Hanna, Youstina, Cirlan, Iulia, Pugh, Trevor J, Mudianto, Tenny, Riley, Rachel, Zhou, Liye, Jo, Vickie Y, Stachler, Matthew D, Hanna, Glenn J, Kass, Jason, Haddad, Robert, Schoenfeld, Jonathan D, Gjini, Evisa, Lako, Ana, Thorstad, Wade, Gay, Hiram A, Daly, Mackenzie, Rodig, Scott J, Hagemann, Ian S, Kallogjeri, Dorina, Piccirillo, Jay F, Chernock, Rebecca D, Griffith, Malachi, Griffith, Obi L, Adkins, Douglas R

“…Pembrolizumab improved survival in patients with recurrent or metastatic head and neck squamous-cell carcinoma (HNSCC). The aims of this study were to…”
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Coenzyme A fuels T cell anti-tumor immunity by St Paul, Michael, Saibil, Samuel D, Han, SeongJun, Israni-Winger, Kavita, Lien, Scott C, Laister, Rob C, Sayad, Azin, Penny, Susanne, Amaria, Rodabe N, Haydu, Lauren E, Garcia-Batres, Carlos R, Kates, Meghan, Mulder, David T, Robert-Tissot, Céline, Gold, Matthew J, Tran, Charles W, Elford, Alisha R, Nguyen, Linh T, Pugh, Trevor J, Pinto, Devanand M, Wargo, Jennifer A, Ohashi, Pamela S

“…Metabolic programming is intricately linked to the anti-tumor properties of T cells. To study the metabolic pathways associated with increased anti-tumor…”
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Enhancing clinical genomic accuracy with panelGC: a novel metric and tool for quantifying and monitoring GC biases in hybridization capture panel sequencing by Cheng, Xuanjin, Goktas, Murathan T, Williamson, Laura M, Krzywinski, Martin, Mulder, David T, Swanson, Lucas, Slind, Jill, Sihvonen, Jelena, Chow, Cynthia R, Carr, Amy, Bosdet, Ian, Tucker, Tracy, Young, Sean, Moore, Richard, Mungall, Karen L, Yip, Stephen, Jones, Steven J M

“…Abstract Accurate assessment of fragment abundance within a genome is crucial in clinical genomics applications such as the analysis of copy number variation…”
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Multiple histidines in the periplasmic domain of the Salmonella enterica sensor kinase SsrA enhance signaling in response to extracellular acidification by Mulder, David T., McPhee, Joseph B., Reid‐Yu, Sarah A., Stogios, Peter J., Savchenko, Alexei, Coombes, Brian K.

“…Summary The two‐component regulatory system SsrA‐SsrB in Salmonella enterica controls expression of a virulence gene program required for intracellular…”
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IL6 Induces an IL22 + CD8 + T-cell Subset with Potent Antitumor Function by St Paul, Michael, Saibil, Samuel D, Lien, Scott C, Han, SeongJun, Sayad, Azin, Mulder, David T, Garcia-Batres, Carlos R, Elford, Alisha R, Israni-Winger, Kavita, Robert-Tissot, Céline, Zon, Michael, Katz, Sarah Rachel, Shaw, Patricia A, Clarke, Blaise A, Bernardini, Marcus Q, Nguyen, Linh T, Haibe-Kains, Benjamin, Pugh, Trevor J, Ohashi, Pamela S

“…CD8 T cells can be polarized into several different subsets as defined by the cytokines they produce and the transcription factors that govern their…”
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Infection biology: Cheats never prosper by Mulder, David T, Coombes, Brian K

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Correction: Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-unrelated Head and Neck Cancer: A Multicenter, Phase II Trial by Uppaluri, Ravindra, Campbell, Katie M, Egloff, Ann Marie, Zolkind, Paul, Skidmore, Zachary L, Nussenbaum, Brian, Paniello, Randal C, Rich, Jason T, Jackson, Ryan, Pipkorn, Patrik, Michel, Loren S, Ley, Jessica, Oppelt, Peter, Dunn, Gavin P, Barnell, Erica K, Spies, Nicholas C, Lin, Tianxiang, Li, Tiantian, Mulder, David T, Hanna, Youstina, Cirlan, Iulia, Pugh, Trevor J, Mudianto, Tenny, Riley, Rachel, Zhou, Liye, Jo, Vickie Y, Stachler, Matthew D, Hanna, Glenn J, Kass, Jason, Haddad, Robert, Schoenfeld, Jonathan D, Gjini, Evisa, Lako, Ana, Thorstad, Wade, Gay, Hiram A, Daly, Mackenzie, Rodig, Scott J, Hagemann, Ian S, Kallogjeri, Dorina, Piccirillo, Jay F, Chernock, Rebecca D, Griffith, Malachi, Griffith, Obi L, Adkins, Douglas R

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Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing by Chow, Signy, Kis, Olena, Mulder, David T, Danesh, Arnavaz, Bruce, Jeff, Wang, Ting Ting, Reece, Donna, Bhalis, Nizar, Neri, Paola, Sabatini, Peter Jb, Keats, Jonathan, Trudel, Suzanne, Pugh, Trevor J

“…Multiple myeloma is a plasma cell neoplasm characterized by clonal immunoglobulin V(D)J signatures and oncogenic immunoglobulin gene translocations. Additional…”
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Cheats never prosper by Mulder, David T., Coombes, Brian K.

“…Fast-growing 'defector mutants' can threaten the success of a bacterial infection. But one bacterial species prevails over these cheats by forming a…”
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CapTCR-seq: hybrid capture for T-cell receptor repertoire profiling by Mulder, David T., Mahé, Etienne R., Dowar, Mark, Hanna, Youstina, Li, Tiantian, Nguyen, Linh T., Butler, Marcus O., Hirano, Naoto, Delabie, Jan, Ohashi, Pamela S., Pugh, Trevor J.

“…Mature T-cell lymphomas consisting of an expanded clonal population of T cells that possess common rearrangements of the T-cell receptor (TCR) encoding genes…”
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The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA by Cooper, Colin A, Mulder, David T, Allison, Sarah E, Pilar, Ana Victoria C, Coombes, Brian K

“…Salmonella enterica is a causative agent of foodborne gastroenteritis and the systemic disease known as typhoid fever. This bacterium uses two type three…”
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Active modification of host inflammation by Salmonella by Pilar, Ana Victoria C., Reid-Yu, Sarah A., Cooper, Colin A., Mulder, David T., Coombes, Brian K.

“…The dampening of host immune responses is a critical aspect of pathogenesis for the enteropathogen Salmonella enterica. Our laboratory has recently described a…”
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Cheats never prosper: fast-growing 'defector mutants' can threaten the success of a bacterial infection. But one bacterial species prevails over these cheats by forming a subpopulation that has shut down expression of virulence genes by Mulder, David T, Coombes, Brian K

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