Search Results - "Mulder, Aat"

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease by Giacomelli, Elisa, Meraviglia, Viviana, Campostrini, Giulia, Cochrane, Amy, Cao, Xu, van Helden, Ruben W.J., Krotenberg Garcia, Ana, Mircea, Maria, Kostidis, Sarantos, Davis, Richard P., van Meer, Berend J., Jost, Carolina R., Koster, Abraham J., Mei, Hailiang, Míguez, David G., Mulder, Aat A., Ledesma-Terrón, Mario, Pompilio, Giulio, Sala, Luca, Salvatori, Daniela C.F., Slieker, Roderick C., Sommariva, Elena, de Vries, Antoine A.F., Giera, Martin, Semrau, Stefan, Tertoolen, Leon G.J., Orlova, Valeria V., Bellin, Milena, Mummery, Christine L.

“…Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally immature, but this is improved by incorporation into engineered…”
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Postmortem MRI and histology demonstrate differential iron accumulation and cortical myelin organization in early- and late-onset Alzheimer's disease by Bulk, Marjolein, Abdelmoula, Walid M., Nabuurs, Rob J.A., van der Graaf, Linda M., Mulders, Coen W.H., Mulder, Aat A., Jost, Carolina R., Koster, Abraham J., van Buchem, Mark A., Natté, Remco, Dijkstra, Jouke, van der Weerd, Louise

“…Previous MRI studies reported cortical iron accumulation in early-onset (EOAD) compared to late-onset (LOAD) Alzheimer disease patients. However, the pattern…”
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Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Family Members With a Pathogenic NOTCH3 Variant Can Have a Normal Brain Magnetic Resonance Imaging and Skin Biopsy Beyond Age 50 Years by Hack, Remco J., Gravesteijn, Gido, Cerfontaine, Minne N., Hegeman, Ingrid M., Mulder, Aat A., Lesnik Oberstein, Saskia A.J., Rutten, Julie W.

“…To determine whether extremely mild small vessel disease (SVD) phenotypes can occur in variant carriers from Cerebral Autosomal Dominant Arteriopathy with…”
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Weibel-Palade Body Localized Syntaxin-3 Modulates Von Willebrand Factor Secretion From Endothelial Cells by Schillemans, Maaike, Karampini, Ellie, van den Eshof, Bart L, Gangaev, Anastasia, Hofman, Menno, van Breevoort, Dorothee, Meems, Henriët, Janssen, Hans, Mulder, Aat A, Jost, Carolina R, Escher, Johanna C, Adam, Rüdiger, Carter, Tom, Koster, Abraham J, van den Biggelaar, Maartje, Voorberg, Jan, Bierings, Ruben

“…OBJECTIVE—Endothelial cells store VWF (von Willebrand factor) in rod-shaped secretory organelles, called Weibel-Palade bodies (WPBs). WPB exocytosis is…”
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Bacteriophage ISP eliminates Staphylococcus aureus in planktonic phase, but not in the various stages of the biofilm cycle by Verheul, Mariëlle, Mulder, Aat A., van Dun, Sven C. J., Merabishvili, Maia, Nelissen, Rob G. H. H., de Boer, Mark G. J., Pijls, Bart G., Nibbering, Peter H.

“…Metal-implant associated bacterial infections are a major clinical problem due to antibiotic treatment failure. As an alternative, we determined the effects of…”
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Syntaxin 5 determines Weibel-Palade body size and Von Willebrand factor secretion by controlling Golgi architecture by Kat, Marije, Karampini, Ellie, Hoogendijk, Arie J, Bürgisser, Petra E, Mulder, Aat A, Van Alphen, Floris P J, Olins, Jenny, Geerts, Dirk, Van den Biggelaar, Maartje, Margadant, Coert, Voorberg, Jan, Bierings, Ruben

“…Von Willebrand factor (VWF) is a multimeric hemostatic protein primarily synthesized in endothelial cells (ECs). VWF is stored in endothelial storage…”
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NOTCH3 variant position is associated with NOTCH3 aggregation load in CADASIL vasculature by Gravesteijn, Gido, Hack, Remco J., Mulder, Aat A., Cerfontaine, Minne N., Doorn, Remco, Hegeman, Ingrid M., Jost, Carolina R., Rutten, Julie W., Lesnik Oberstein, Saskia A. J.

“…Aims CADASIL, the most prevalent hereditary cerebral small vessel disease, is caused by cysteine‐altering NOTCH3 variants (NOTCH3cys) leading to vascular…”
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Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration by Nguyen, Phong D, Gooijers, Iris, Campostrini, Giulia, Verkerk, Arie O, Honkoop, Hessel, Bouwman, Mara, de Bakker, Dennis E M, Koopmans, Tim, Vink, Aryan, Lamers, Gerda E M, Shakked, Avraham, Mars, Jonas, Mulder, Aat A, Chocron, Sonja, Bartscherer, Kerstin, Tzahor, Eldad, Mummery, Christine L, de Boer, Teun P, Bellin, Milena, Bakkers, Jeroen

“…Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the proliferation of surviving…”
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Smad6 determines BMP-regulated invasive behaviour of breast cancer cells in a zebrafish xenograft model by de Boeck, Miriam, Cui, Chao, Mulder, Aat A, Jost, Carolina R, Ikeno, Souichi, ten Dijke, Peter

“…The transforming growth factor-β (TGF-β) family is known to play critical roles in cancer progression. While the dual role of TGF-β is well described, the…”
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Tumor Pigmentation Does Not Affect Light-Activated Belzupacap Sarotalocan Treatment but Influences Macrophage Polarization in a Murine Melanoma Model by Ma, Sen, Huis In't Veld, Ruben V, Hao, Yang, Gu, Zili, Rich, Cadmus, Gelmi, Maria Chiara, Mulder, Aat A, van Veelen, Peter A, Vu, T Khanh H, van Hall, Thorbald, Ossendorp, Ferry A, Jager, Martine J

“…Pigmentation in uveal melanoma is associated with increased malignancy and is known as a barrier for photodynamic therapy. We investigated the role of…”
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Loss of CRB2 in Müller glial cells modifies a CRB1-associated retinitis pigmentosa phenotype into a Leber congenital amaurosis phenotype by Quinn, Peter M, Mulder, Aat A, Henrique Alves, C, Desrosiers, Mélissa, de Vries, Sharon I, Klooster, Jan, Dalkara, Deniz, Koster, Abraham J, Jost, Carolina R, Wijnholds, Jan

“…Abstract Variations in the human Crumbs homolog-1 (CRB1) gene lead to an array of retinal dystrophies including early onset of retinitis pigmentosa (RP) and…”
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CRB2 Loss in Rod Photoreceptors Is Associated with Progressive Loss of Retinal Contrast Sensitivity by Alves, C Henrique, Boon, Nanda, Mulder, Aat A, Koster, Abraham J, Jost, Carolina R, Wijnholds, Jan

“…Variations in the Crumbs homolog-1 ( ) gene are associated with a wide variety of autosomal recessive retinal dystrophies, including early onset retinitis…”
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Red blood cells as oxygen carrier during normothermic machine perfusion of kidney grafts: Friend or foe? by Arykbaeva, Asel S., Lerink, Lente J.S., Vos, Jaël, Engelse, Marten A., van Kooten, Cees, de Korte, Dirk, Lagerberg, Johan W.M., Klei, Thomas R.L., Mulder, Aat A., Minnee, Robert C., Ploeg, Rutger J., Kers, Jesper, Moers, Cyril, Pol, Robert A., Alwayn, Ian P.J., de Vries, Dorottya K., Lindeman, Jan H.N.

“…Renal ex vivo normothermic machine perfusion (NMP) is under development as an assessment tool for high-risk kidney grafts and as a means of achieving more…”
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In vitro modelling of alveolar repair at the air-liquid interface using alveolar epithelial cells derived from human induced pluripotent stem cells by van Riet, Sander, Ninaber, Dennis K., Mikkers, Harald M. M., Tetley, Teresa D., Jost, Carolina R., Mulder, Aat A., Pasman, Thijs, Baptista, Danielle, Poot, André A., Truckenmüller, Roman, Mummery, Christine L., Freund, Christian, Rottier, Robbert J., Hiemstra, Pieter S.

“…Research on acute and chronic lung diseases would greatly benefit from reproducible availability of alveolar epithelial cells (AEC). Primary alveolar…”
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Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5 by Quinn, Peter M., Buck, Thilo M., Mulder, Aat A., Ohonin, Charlotte, Alves, C. Henrique, Vos, Rogier M., Bialecka, Monika, van Herwaarden, Tessa, van Dijk, Elon H.C., Talib, Mays, Freund, Christian, Mikkers, Harald M.M., Hoeben, Rob C., Goumans, Marie-José, Boon, Camiel J.F., Koster, Abraham J., Chuva de Sousa Lopes, Susana M., Jost, Carolina R., Wijnholds, Jan

“…Human retinal organoids from induced pluripotent stem cells (hiPSCs) can be used to confirm the localization of proteins in retinal cell types and to test…”
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Defining Phenotype, Tropism, and Retinal Gene Therapy Using Adeno-Associated Viral Vectors (AAVs) in New-Born Brown Norway Rats with a Spontaneous Mutation in Crb1 by Boon, Nanda, Alves, C Henrique, Mulder, Aat A, Andriessen, Charlotte A, Buck, Thilo M, Quinn, Peter M J, Vos, Rogier M, Koster, Abraham J, Jost, Carolina R, Wijnholds, Jan

“…Mutations in the Crumbs homologue 1 ( ) gene cause inherited retinal dystrophies, such as early-onset retinitis pigmentosa and Leber congenital amaurosis. A…”
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CRB1 is required for recycling by RAB11A+ vesicles in human retinal organoids by Buck, Thilo M., Quinn, Peter M.J., Pellissier, Lucie P., Mulder, Aat A., Jongejan, Aldo, Lu, Xuefei, Boon, Nanda, Koot, Daniëlle, Almushattat, Hind, Arendzen, Christiaan H., Vos, Rogier M., Bradley, Edward J., Freund, Christian, Mikkers, Harald M.M., Boon, Camiel J.F., Moerland, Perry D., Baas, Frank, Koster, Abraham J., Neefjes, Jacques, Berlin, Ilana, Jost, Carolina R., Wijnholds, Jan

“…CRB1 gene mutations can cause early- or late-onset retinitis pigmentosa, Leber congenital amaurosis, or maculopathy. Recapitulating human CRB1 phenotypes in…”
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Increased Presence of Monounsaturated Fatty Acids in the Stratum Corneum of Human Skin Equivalents by Thakoersing, Varsha S., van Smeden, Jeroen, Mulder, Aat A., Vreeken, Rob J., El Ghalbzouri, Abdoelwaheb, Bouwstra, Joke A.

“…Previous results showed that our in-house human skin equivalents (HSEs) differ in their stratum corneum (SC) lipid organization compared with human SC. To…”
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Naturally occurring NOTCH3 exon skipping attenuates NOTCH3 protein aggregation and disease severity in CADASIL patients by Gravesteijn, Gido, Dauwerse, Johannes G, Overzier, Maurice, Brouwer, Gwendolyn, Hegeman, Ingrid, Mulder, Aat A, Baas, Frank, Kruit, Mark C, Terwindt, Gisela M, van Duinen, Sjoerd G, Jost, Carolina R, Aartsma-Rus, Annemieke, Lesnik Oberstein, Saskia A J, Rutten, Julie W

“…CADASIL is a vascular protein aggregation disorder caused by cysteine-altering NOTCH3 variants, leading to mid-adult-onset stroke and dementia. Here, we report…”
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Oncogenomic analysis of mycosis fungoides reveals major differences with Sézary syndrome by van Doorn, Remco, van Kester, Marloes S., Dijkman, Remco, Vermeer, Maarten H., Mulder, Aat A., Szuhai, Karoly, Knijnenburg, Jeroen, Boer, Judith M., Willemze, Rein, Tensen, Cornelis P.

“…Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma, is a malignancy of mature, skin-homing T cells. Sézary syndrome (Sz) is often considered to…”
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