Search Results - "Mulcair, Mark D"

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death by Hildebrand, Joanne M., Tanzer, Maria C., Lucet, Isabelle S., Young, Samuel N., Spall, Sukhdeep K., Sharma, Pooja, Pierotti, Catia, Garnier, Jean-Marc, Dobson, Renwick C.J., Webb, Andrew I., Tripaydonis, Anne, Babon, Jeffrey J., Mulcair, Mark D., Scanlon, Martin J., Alexander, Warren S., Wilks, Andrew F., Czabotar, Peter E., Lessene, Guillaume, Murphy, James M., Silke, John

“…Significance The four-helix bundle (4HB) domain of Mixed Lineage Kinase Domain-Like (MLKL) bears two clusters of residues that are required for cell death by…”
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Application of Fragment-Based Screening to the Design of Inhibitors of Escherichia coli DsbA by Adams, Luke A., Sharma, Pooja, Mohanty, Biswaranjan, Ilyichova, Olga V., Mulcair, Mark D., Williams, Martin L., Gleeson, Ellen C., Totsika, Makrina, Doak, Bradley C., Caria, Sofia, Rimmer, Kieran, Horne, James, Shouldice, Stephen R., Vazirani, Mansha, Headey, Stephen J., Plumb, Brent R., Martin, Jennifer L., Heras, Begoña, Simpson, Jamie S., Scanlon, Martin J.

“…The thiol‐disulfide oxidoreductase enzyme DsbA catalyzes the formation of disulfide bonds in the periplasm of Gram‐negative bacteria. DsbA substrates include…”
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Characterization of Gibberellin Receptor Mutants of Barley (Hordeum vulgare L.) by Chandler, Peter M., Harding, Carol A., Ashton, Anthony R., Mulcair, Mark D., Dixon, Nicholas E., Mander, Lewis N.

“…The sequence of Gid1 (a gene for a gibberellin (GA) receptor from rice) was used to identify a putative orthologue from barley. This was expressed in E. coli…”
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Promiscuous 2‑Aminothiazoles (PrATs): A Frequent Hitting Scaffold by Devine, Shane M, Mulcair, Mark D, Debono, Cael O, Leung, Eleanor W. W, Nissink, J. Willem M, Lim, San Sui, Chandrashekaran, Indu R, Vazirani, Mansha, Mohanty, Biswaranjan, Simpson, Jamie S, Baell, Jonathan B, Scammells, Peter J, Norton, Raymond S, Scanlon, Martin J

“…We have identified a class of molecules, known as 2-aminothiazoles (2-ATs), as frequent-hitting fragments in biophysical binding assays. This was exemplified…”
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19F NMR as a Probe of Ligand Interactions with the iNOS Binding site of SPRY Domain-Containing SOCS Box Protein 2 by Leung, Eleanor W. W., Yagi, Hiromasa, Harjani, Jitendra R., Mulcair, Mark D., Scanlon, Martin J., Baell, Jonathan B., Norton, Raymond S.

“…SPRY domain‐containing SOCS box protein 2 (SPSB2) regulates inducible nitric oxide synthase (iNOS) by targeting it for proteasomal degradation. Inhibiting this…”
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A Molecular Mousetrap Determines Polarity of Termination of DNA Replication in E. coli by Mulcair, Mark D., Schaeffer, Patrick M., Oakley, Aaron J., Cross, Hannah F., Neylon, Cameron, Hill, Thomas M., Dixon, Nicholas E.

“…During chromosome synthesis in Escherichia coli, replication forks are blocked by Tus bound Ter sites on approach from one direction but not the other. To…”
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Application of Fragment-Based Screening to the Design of Inhibitors of Escherichia coli DsbA by Adams, Luke A., Sharma, Pooja, Mohanty, Biswaranjan, Ilyichova, Olga V., Mulcair, Mark D., Williams, Martin L., Gleeson, Ellen C., Totsika, Makrina, Doak, Bradley C., Caria, Sofia, Rimmer, Kieran, Horne, James, Shouldice, Stephen R., Vazirani, Mansha, Headey, Stephen J., Plumb, Brent R., Martin, Jennifer L., Heras, Begoña, Simpson, Jamie S., Scanlon, Martin J.

“…The thiol‐disulfide oxidoreductase enzyme DsbA catalyzes the formation of disulfide bonds in the periplasm of Gram‐negative bacteria. DsbA substrates include…”
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19 F NMR as a Probe of Ligand Interactions with the iNOS Binding site of SPRY Domain‐Containing SOCS Box Protein 2 by Leung, Eleanor W. W., Yagi, Hiromasa, Harjani, Jitendra R., Mulcair, Mark D., Scanlon, Martin J., Baell, Jonathan B., Norton, Raymond S.

“…SPRY domain‐containing SOCS box protein 2 (SPSB2) regulates inducible nitric oxide synthase ( iNOS ) by targeting it for proteasomal degradation. Inhibiting…”
Get full text