A Comparison of Outcomes from Antibiotic Treatment with and without Probiotics in 897 Patients with Lower Urogenital Tract Infections, Including Cystitis, Urethritis, Prostatitis, and Vulvovaginitis

BACKGROUND Urogenital bacterial infections have a high incidence in humans. The most frequent cause of infections of the urogenital tract is gram-negative bacteria. Antibiotics are very effective in curing infectious diseases but they are accompanied by health complications. Probiotics are live micr...

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Bibliographic Details
Published in:	Medical science monitor. Basic research Vol. 30; pp. e943939 - e943939-10
Main Authors:	Mula, Dea, Dervishi, Rinon, Hoxha, Rina, Dervishi, Lutfi, Gashi, Musli Mon, Muçaj, Sefedin, Muçaj, Elza, Kuçi, Leart
Format:	Journal Article
Language:	English
Published:	United States International Scientific Literature, Inc 26-06-2024
Subjects:	Adolescent Adult Anti-Bacterial Agents - therapeutic use Cystitis - drug therapy Female Humans Male Middle Aged Pharmaceutical Research Probiotics - therapeutic use Prostatitis - drug therapy Prostatitis - microbiology Treatment Outcome Urethritis - drug therapy Urethritis - microbiology Urinary Tract Infections - drug therapy Vulvovaginitis - drug therapy Vulvovaginitis - microbiology Young Adult
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Summary:	BACKGROUND Urogenital bacterial infections have a high incidence in humans. The most frequent cause of infections of the urogenital tract is gram-negative bacteria. Antibiotics are very effective in curing infectious diseases but they are accompanied by health complications. Probiotics are live microorganisms that are believed to confer a beneficial effect on human health when consumed in adequate amounts. This study aimed to compare outcomes from antibiotic treatment with and without the use of probiotics in 897 patients with lower urogenital tract infections, including cystitis, urethritis, prostatitis, and vulvovaginitis. MATERIAL AND METHODS A total of 897 patients aged 18 to 55 years were included in this research. Patients were divided into an intervention group including 460 patients (254 women, 206 men) and a comparison group including 437 patients (240 women, 197 men). The probiotics received by patients were capsules of ProBalans®. The diagnosis of cystitis, urethritis, prostatitis, vulvovaginitis, and sexually transmitted infection was done using several tests, and antibiotics were used for treatment. Qualitative data were analyzed using the chi-square or Fisher exact test. RESULTS We found a significant difference regarding patients' impressions of improvement after therapy between patients in the intervention group and the comparison group. CONCLUSIONS Use of probiotics together with antibiotics in the treatment of urogenital tract infection can help to reduce the adverse effects of antibiotics, increase the efficiency of antibiotic therapy, and reduce bacterial resistance to antibiotics. However, further research is needed to confirm these potential health benefits.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Funds Collection Data Interpretation Literature Search Data Collection Study Design Manuscript Preparation Statistical Analysis
ISSN:	2325-4416 2325-4394 2325-4416
DOI:	10.12659/MSMBR.943939