Molecular Understanding and Pharmacological Potency of Plant-Derived Compounds in Colorectal Cancer (CRC): A Critical Analysis and Future Perspectives

Colorectal cancer (CRC) is the main driver of fatality and the 3rd most often determined malignancy. Despite advances in detection and therapy, colorectal cancer (CRC) endures as the largest driver of cancer-related morbidity, and mortality. Modern habits and dietary negligence might be one of the r...

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Bibliographic Details
Published in:	Cell biochemistry and biophysics Vol. 82; no. 3; pp. 1777 - 1795
Main Authors:	Mukkavilli, Vaagdevi, Ramakrishnan, Gnanasekaran, Gujjula, Koteswara Reddy, S, Balachandran, Chamarthy, Sahiti, Mekala, Janaki Ramaiah
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-09-2024 Springer Nature B.V
Subjects:	Apoptosis Apoptosis - drug effects Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biotechnology Cancer Cell activation Cell Biology Cell cycle Chromatin Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Curcumin Epigenesis, Genetic - drug effects Epigenetics Flavonoids Flavonoids - chemistry Flavonoids - pharmacology Flavonoids - therapeutic use Humans Life Sciences Malignancy MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Morbidity Natural products Negligence Pharmacology Pharmacology/Toxicology Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Plants Propagation Resveratrol Review Paper Signal transduction Flavonoids Curcumin Ellagitannins Colorectal cancer Resveratrol
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Summary:	Colorectal cancer (CRC) is the main driver of fatality and the 3rd most often determined malignancy. Despite advances in detection and therapy, colorectal cancer (CRC) endures as the largest driver of cancer-related morbidity, and mortality. Modern habits and dietary negligence might be one of the reasons that have enhanced cancer prevalence. Thus, changes in Dietary habits will have a better impact, and help in finding a better cure for CRC. Initially, CRC was explored as a genetic event and currently, the research is focused on the epigenetic modifications of chromatin and microRNA (miRNA) in CRC cells. Natural products such as Curcumin, Resveratrol, Flavonoids, and Ellagitannins are been explored as compounds from the perspective of genetic, epigenetic, and miRNA modifications which will have future therapeutic aspects. Also, the extracts of these key players and their analogs will intervene the signaling pathway activation that involves in cancer propagation, apoptosis, cell cycle arrest, and epigenetic and miRNA modifications. Modulations of these miRNAs, and modification globally might have impact on CRC progression, and cancer tumor cell sensitivity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1085-9195 1559-0283 1559-0283
DOI:	10.1007/s12013-024-01370-1