Search Results - "Mukhopadhyay, Pamela"

MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota by Koyama, Motoko, Mukhopadhyay, Pamela, Schuster, Iona S., Henden, Andrea S., Hülsdünker, Jan, Varelias, Antiopi, Vetizou, Marie, Kuns, Rachel D., Robb, Renee J., Zhang, Ping, Blazar, Bruce R., Thomas, Ranjeny, Begun, Jakob, Waddell, Nicola, Trinchieri, Giorgio, Zeiser, Robert, Clouston, Andrew D., Degli-Esposti, Mariapia A., Hill, Geoffrey R.

“…Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract is the principal determinant of lethality following allogeneic bone marrow transplantation…”
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Progression of Osteosarcoma from a Non-Metastatic to a Metastatic Phenotype Is Causally Associated with Activation of an Autocrine and Paracrine uPA Axis by Endo-Munoz, Liliana, Cai, Na, Cumming, Andrew, Macklin, Rebecca, Merida de Long, Lilia, Topkas, Eleni, Mukhopadhyay, Pamela, Hill, Michelle, Saunders, Nicholas A

“…Pulmonary metastasis is the major untreatable complication of osteosarcoma (OS) resulting in 10-20% long-term survival. The factors and pathways regulating…”
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Chromatin interactome mapping at 139 independent breast cancer risk signals by Beesley, Jonathan, Sivakumaran, Haran, Moradi Marjaneh, Mahdi, Lima, Luize G, Hillman, Kristine M, Kaufmann, Susanne, Tuano, Natasha, Hussein, Nehal, Ham, Sunyoung, Mukhopadhyay, Pamela, Kazakoff, Stephen, Lee, Jason S, Michailidou, Kyriaki, Barnes, Daniel R, Antoniou, Antonis C, Fachal, Laura, Dunning, Alison M, Easton, Douglas F, Waddell, Nicola, Rosenbluh, Joseph, Möller, Andreas, Chenevix-Trench, Georgia, French, Juliet D, Edwards, Stacey L

“…Genome-wide association studies have identified 196 high confidence independent signals associated with breast cancer susceptibility. Variants within these…”
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Different genetic mechanisms mediate spontaneous versus UVR-induced malignant melanoma by Ferguson, Blake, Handoko, Herlina Y, Mukhopadhyay, Pamela, Chitsazan, Arash, Balmer, Lois, Morahan, Grant, Walker, Graeme J

“…Genetic variation conferring resistance and susceptibility to carcinogen-induced tumorigenesis is frequently studied in mice. We have now turned this idea to…”
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Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia by Vu, Therese, Straube, Jasmin, Porter, Amy H., Bywater, Megan, Song, Axia, Ling, Victoria, Cooper, Leanne, Pali, Gabor, Bruedigam, Claudia, Jacquelin, Sebastien, Green, Joanne, Magor, Graham, Perkins, Andrew, Chalk, Alistair M., Walkley, Carl R., Heidel, Florian H., Mukhopadhyay, Pamela, Cloonan, Nicole, Gröschel, Stefan, Mallm, Jan-Philipp, Fröhling, Stefan, Scholl, Claudia, Lane, Steven W.

“…The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells but not during normal blood formation. Retroviral overexpression of Cdx2…”
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Lower temperatures reduce type I interferon activity and promote alphaviral arthritis by Prow, Natalie A, Tang, Bing, Gardner, Joy, Le, Thuy T, Taylor, Adam, Poo, Yee S, Nakayama, Eri, Hirata, Thiago D C, Nakaya, Helder I, Slonchak, Andrii, Mukhopadhyay, Pamela, Mahalingam, Suresh, Schroder, Wayne A, Klimstra, William, Suhrbier, Andreas

“…Chikungunya virus (CHIKV) belongs to a group of mosquito-borne alphaviruses associated with acute and chronic arthropathy, with peripheral and limb joints most…”
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Exacerbation of Chikungunya Virus Rheumatic Immunopathology by a High Fiber Diet and Butyrate by Prow, Natalie A, Hirata, Thiago D C, Tang, Bing, Larcher, Thibaut, Mukhopadhyay, Pamela, Alves, Tiago Lubiana, Le, Thuy T, Gardner, Joy, Poo, Yee Suan, Nakayama, Eri, Lutzky, Viviana P, Nakaya, Helder I, Suhrbier, Andreas

“…Chikungunya virus (CHIKV) is a mosquito transmitted alphavirus associated with a robust systemic infection and an acute inflammatory rheumatic disease. A high…”
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RacGAP1 Is a Novel Downstream Effector of E2F7-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell Carcinoma by Hazar-Rethinam, Mehlika, de Long, Lilia Merida, Gannon, Orla M, Boros, Samuel, Vargas, Ana Cristina, Dzienis, Marcin, Mukhopadhyay, Pamela, Saenz-Ponce, Natalia, Dantzic, Daniel D E, Simpson, Fiona, Saunders, Nicholas A

“…We have previously shown that E2F7 contributes to drug resistance in head and neck squamous cell carcinoma (HNSCC) cells. Considering that dysregulation of…”
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Genetic variation in the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway affects contact hypersensitivity responses by Legrand, Julien M.D., Roy, Edwige, Baz, Batoul, Mukhopadhyay, Pamela, Wong, Ho Yi, Ram, Ramesh, Morahan, Grant, Walker, Graeme, Khosrotehrani, Kiarash

“…[...]susceptibility to the development of ACD is related to the presence of genetic variations such as single nucleotide polymorphisms in genes relevant to…”
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Keratinocyte Sonic Hedgehog Upregulation Drives the Development of Giant Congenital Nevi via Paracrine Endothelin-1 Secretion by Chitsazan, Arash, Ferguson, Blake, Villani, Rehan, Handoko, Herlina Y., Mukhopadhyay, Pamela, Gabrielli, Brian, Mooi, Wolter J., Soyer, H. Peter, Lambie, Duncan, Khosrotehrani, Kiarash, Morahan, Grant, Walker, Graeme J.

“…Giant congenital nevi are associated with clinical complications such as neurocutaneous melanosis and melanoma. Virtually nothing is known about why some…”
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Integrative temporal multi-omics reveals uncoupling of transcriptome and proteome during human T cell activation by Weerakoon, Harshi, Mohamed, Ahmed, Wong, Yide, Chen, Jinjin, Senadheera, Bhagya, Haigh, Oscar, Watkins, Thomas S., Kazakoff, Stephen, Mukhopadhyay, Pamela, Mulvenna, Jason, Miles, John J., Hill, Michelle M., Lepletier, Ailin

“…Engagement of the T cell receptor (TCR) triggers molecular reprogramming leading to the acquisition of specialized effector functions by CD4 helper and CD8…”
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ERK and mTORC1 Inhibitors Enhance the Anti-Cancer Capacity of the Octpep-1 Venom-Derived Peptide in Melanoma BRAF(V600E) Mutations by Moral-Sanz, Javier, Fernandez-Rojo, Manuel A, Potriquet, Jeremy, Mukhopadhyay, Pamela, Brust, Andreas, Wilhelm, Patrick, Smallwood, Taylor B, Clark, Richard J, Fry, Bryan G, Alewood, Paul F, Waddell, Nicola, Miles, John J, Mulvenna, Jason P, Ikonomopoulou, Maria P

“…Melanoma is the main cause of skin cancer deaths, with special emphasis in those cases carrying BRAF mutations that trigger the mitogen-activated protein…”
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Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions by Wang, Xiangju, Wilkinson, Ray, Kildey, Katrina, Potriquet, Jeremy, Mulvenna, Jason, Lobb, Richard J., Möller, Andreas, Cloonan, Nicole, Mukhopadhyay, Pamela, Kassianos, Andrew J., Healy, Helen

“…Human proximal tubular epithelial cells (PTEC) of the kidney are known to respond to and mediate the disease process in a wide range of kidney diseases, yet…”
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Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation by Mould, Arne W, Pang, Zhenyi, Pakusch, Miha, Tonks, Ian D, Stark, Mitchell, Carrie, Dianne, Mukhopadhyay, Pamela, Seidel, Annica, Ellis, Jonathan J, Deakin, Janine, Wakefield, Matthew J, Krause, Lutz, Blewitt, Marnie E, Kay, Graham F

“…Smchd1 is an epigenetic modifier essential for X chromosome inactivation: female embryos lacking Smchd1 fail during midgestational development. Male mice are…”
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Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets by Newell, Felicity, Kong, Yan, Wilmott, James S., Johansson, Peter A., Ferguson, Peter M., Cui, Chuanliang, Li, Zhongwu, Kazakoff, Stephen H., Burke, Hazel, Dodds, Tristan J., Patch, Ann-Marie, Nones, Katia, Tembe, Varsha, Shang, Ping, van der Weyden, Louise, Wong, Kim, Holmes, Oliver, Lo, Serigne, Leonard, Conrad, Wood, Scott, Xu, Qinying, Rawson, Robert V., Mukhopadhyay, Pamela, Dummer, Reinhard, Levesque, Mitchell P., Jönsson, Göran, Wang, Xuan, Yeh, Iwei, Wu, Hong, Joseph, Nancy, Bastian, Boris C., Long, Georgina V., Spillane, Andrew J., Shannon, Kerwin F., Thompson, John F., Saw, Robyn P. M., Adams, David J., Si, Lu, Pearson, John V., Hayward, Nicholas K., Waddell, Nicola, Mann, Graham J., Guo, Jun, Scolyer, Richard A.

“…Knowledge of key drivers and therapeutic targets in mucosal melanoma is limited due to the paucity of comprehensive mutation data on this rare tumor type. To…”
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CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan by Vennin, Claire, Mélénec, Pauline, Rouet, Romain, Nobis, Max, Cazet, Aurélie S., Murphy, Kendelle J., Herrmann, David, Reed, Daniel A., Lucas, Morghan C., Warren, Sean C., Elgundi, Zehra, Pinese, Mark, Kalna, Gabriella, Roden, Daniel, Samuel, Monisha, Zaratzian, Anaiis, Grey, Shane T., Da Silva, Andrew, Leung, Wilfred, Mathivanan, Suresh, Wang, Yingxiao, Braithwaite, Anthony W., Christ, Daniel, Benda, Ales, Parkin, Ashleigh, Phillips, Phoebe A., Whitelock, John M., Gill, Anthony J., Sansom, Owen J., Croucher, David R., Parker, Benjamin L., Pajic, Marina, Morton, Jennifer P., Cox, Thomas R., Timpson, Paul

“…Heterogeneous subtypes of cancer-associated fibroblasts (CAFs) coexist within pancreatic cancer tissues and can both promote and restrain disease progression…”
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Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance by Newell, Felicity, Pires da Silva, Ines, Johansson, Peter A., Menzies, Alexander M., Wilmott, James S., Addala, Venkateswar, Carlino, Matteo S., Rizos, Helen, Nones, Katia, Edwards, Jarem J., Lakis, Vanessa, Kazakoff, Stephen H., Mukhopadhyay, Pamela, Ferguson, Peter M., Leonard, Conrad, Koufariotis, Lambros T., Wood, Scott, Blank, Christian U., Thompson, John F., Spillane, Andrew J., Saw, Robyn P.M., Shannon, Kerwin F., Pearson, John V., Mann, Graham J., Hayward, Nicholas K., Scolyer, Richard A., Waddell, Nicola, Long, Georgina V.

“…We concurrently examine the whole genome, transcriptome, methylome, and immune cell infiltrates in baseline tumors from 77 patients with advanced cutaneous…”
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Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes by Pattabiraman, Diwakar R., McGirr, Crystal, Shakhbazov, Konstantin, Barbier, Valerie, Krishnan, Keerthana, Mukhopadhyay, Pamela, Hawthorne, Paula, Trezise, Ann, Ding, Jianmin, Grimmond, Sean M., Papathanasiou, Peter, Alexander, Warren S., Perkins, Andrew C., Levesque, Jean-Pierre, Winkler, Ingrid G., Gonda, Thomas J.

“…The MYB oncogene is widely expressed in acute leukemias and is important for the continued proliferation of leukemia cells, suggesting that MYB may be a…”
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Combined Inhibition of G9a and EZH2 Suppresses Tumor Growth via Synergistic Induction of IL24-Mediated Apoptosis by Casciello, Francesco, Kelly, Gregory M, Ramarao-Milne, Priya, Kamal, Nabilah, Stewart, Teneale A, Mukhopadhyay, Pamela, Kazakoff, Stephen H, Miranda, Mariska, Kim, Dorim, Davis, Felicity M, Hayward, Nicholas K, Vertino, Paula M, Waddell, Nicola, Gannon, Frank, Lee, Jason S

“…G9a and EZH2 are two histone methyltransferases commonly upregulated in several cancer types, yet the precise roles that these enzymes play cooperatively in…”
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Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study by Leo, Paul J, Madeleine, Margaret M, Wang, Sophia, Schwartz, Stephen M, Newell, Felicity, Pettersson-Kymmer, Ulrika, Hemminki, Kari, Hallmans, Goran, Tiews, Sven, Steinberg, Winfried, Rader, Janet S, Castro, Felipe, Safaeian, Mahboobeh, Franco, Eduardo L, Coutlée, François, Ohlsson, Claes, Cortes, Adrian, Marshall, Mhairi, Mukhopadhyay, Pamela, Cremin, Katie, Johnson, Lisa G, Trimble, Cornelia L, Garland, Suzanne, Tabrizi, Sepehr N, Wentzensen, Nicolas, Sitas, Freddy, Little, Julian, Cruickshank, Maggie, Frazer, Ian H, Hildesheim, Allan, Brown, Matthew A

“…A small percentage of women with cervical HPV infection progress to cervical neoplasia, and the risk factors determining progression are incompletely…”
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