Real-world utilization pattern of dydrogesterone in 7287 Indian women with obstetric and gynecological conditions: data from multicentric, retrospective study

Real-world utilization pattern of dydrogesterone in 7287 Indian women with obstetric and gynecological conditions: data from multicentric, retrospective study

Despite the literature on dydrogesterone, studies on dydrogesterone utilization patterns are largely lacking in Indian patients. This was a multi-center, retrospective, observational, cross-sectional, and descriptive study across 817 centers in India. Data of patients who received dydrogesterone in...

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Published in:Revista Brasileira de ginecologia e obstetrícia Vol. 46
Main Authors: Tank, Jaydeep, Gupte, Sanjay, Mahapatra, Purna Chandra, Reddy, Jayanthi, Mittal, Pratima, Mukhopadhyay, Ashish Kumar, Vyas, Lila, Batra, Achla, Gupta, Mahesh, Tandulwadkar, Sunita, Chandra, Sunita, Bhat, Vidya, Bapat, Kawita, Tank, Parikshit, Kulkarni, Ketan, Swami, Onkar
Format: Journal Article
Language:English
Published: Brazil Federação Brasileira das Sociedades de Ginecologia e Obstetrícia 01-01-2024
Subjects:
Abortion, Habitual - drug therapy
Abortion, Habitual - epidemiology
Abortion, Threatened - drug therapy
Adult
Comorbid conditions
Concomitant medications
Cross-Sectional Studies
Dydrogesterone
Dydrogesterone - administration & dosage
Dydrogesterone - therapeutic use
Female
Gynecological conditions
Humans
India
Indian women
OBSTETRICS & GYNECOLOGY
Original
Pregnancy
Progestins - administration & dosage
Progestins - therapeutic use
Retrospective Studies
Risk factors
Threatened abortion
Utilization pattern
Young Adult
India
Dydrogesterone
Utilization pattern
Gynecological conditions
Comorbid conditions
Threatened abortion
Concomitant medications
Risk factors
Indian women
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Summary:Despite the literature on dydrogesterone, studies on dydrogesterone utilization patterns are largely lacking in Indian patients. This was a multi-center, retrospective, observational, cross-sectional, and descriptive study across 817 centers in India. Data of patients who received dydrogesterone in past and provided consent for future use of their medical record for research purpose was were retrieved and analyzed. Data of 7287 subjects (aged 29.55±4.84 years) was analyzed. Threatened abortion was the most common indication for which the subjects received dydrogesterone (46.9%) followed by recurrent pregnancy loss. Polycystic ovary syndrome (PCOS), thyroid disorders and anemia were the most common comorbid conditions and prior pregnancy loss, advanced maternal age and obesity were the most common risk factors seen in subjects who received dydrogesterone. Total 27.5% of subjects received a loading dose of dydrogesterone, and majority (64%) received 40 mg as loading dose. 10 mg dose was used as maintenance or regular dose in 81.4% of the subjects. Twice daily (BID) was the most common dosing frequency (66.6%). The most common concomitant medications being taken by the subjects on dydrogesterone included folic acid (45.1%), iron supplements (30.3%) and calcium and vitamin D3 supplements (25.5%). Another progesterone preparation (oral, injection, vaginal, tubal) other than dydrogesterone was used concurrently in 7.8% of subjects. The study helped to identify the patient population that is benefitted by dydrogesterone and the preferred indications, risk factors, comorbid conditions and concomitant medication used in this patient population at real-life scenario.
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Conflicts to interest: none to declare.
Associate Editor Rogério Bonassi Machado (https://orcid.org/0000-0001-9361-0905) Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brazil
ISSN:0100-7203
1806-9339
1806-9339
DOI:10.61622/rbgo/2024AO18