Search Results - "Mukhi, Dhanunjay"

Molecular pathways that drive diabetic kidney disease by Mohandes, Samer, Doke, Tomohito, Hu, Hailong, Mukhi, Dhanunjay, Dhillon, Poonam, Susztak, Katalin

“…Kidney disease is a major driver of mortality among patients with diabetes and diabetic kidney disease (DKD) is responsible for close to half of all chronic…”
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The transcriptomic signature of the aging podocyte by Mukhi, Dhanunjay, Susztak, Katalin

“…Aging is the strongest independent risk factor for chronic kidney disease. Glomerular epithelial cells are unable to proliferate and have limited ability to…”
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Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration by Balzer, Michael S., Doke, Tomohito, Yang, Ya-Wen, Aldridge, Daniel L., Hu, Hailong, Mai, Hung, Mukhi, Dhanunjay, Ma, Ziyuan, Shrestha, Rojesh, Palmer, Matthew B., Hunter, Christopher A., Susztak, Katalin

“…The kidney has tremendous capacity to repair after acute injury, however, pathways guiding adaptive and fibrotic repair are poorly understood. We developed a…”
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Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria by Nishad, Rajkishor, Mukhi, Dhanunjay, Singh, Ashish Kumar, Motrapu, Manga, Chintala, Kumaraswami, Tammineni, Prasad, Pasupulati, Anil K.

“…Glomerular podocytes are integral members of the glomerular filtration barrier in the kidney and are crucial for glomerular permselectivity. These highly…”
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Hypoxia induces ZEB2 in podocytes: Implications in the pathogenesis of proteinuria by Nakuluri, Krishnamurthy, Mukhi, Dhanunjay, Nishad, Rajkishor, Saleem, Moin A., Mungamuri, Sathish Kumar, Menon, Ram K., Pasupulati, Anil Kumar

“…The glomerular filtration barrier (GFB) plays a critical role in ensuing protein free urine. The integrity of the GFB is compromised during hypoxia that…”
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Novel Actions of Growth Hormone in Podocytes: Implications for Diabetic Nephropathy by Mukhi, Dhanunjay, Nishad, Rajkishor, Menon, Ram K, Pasupulati, Anil Kumar

“…The kidney regulates water, electrolyte, and acid-base balance and thus maintains body homeostasis. The kidney's potential to ensure ultrafiltered and almost…”
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Growth Hormone and Metabolic Homeostasis by Nishad, Rajkishor, Mukhi, Dhanunjay, Menon, Ram K., Pasupulati, Anil K.

“…Pituitary growth hormone (GH) is a peptide hormone predominantly secreted by somatotrophs in the anterior pituitary under the tight control of the…”
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NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury by Doke, Tomohito, Mukherjee, Sarmistha, Mukhi, Dhanunjay, Dhillon, Poonam, Abedini, Amin, Davis, James G., Chellappa, Karthikeyani, Chen, Beishan, Baur, Joseph A., Susztak, Katalin

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Acyl-CoA Synthetase Short-Chain Family 2 Is a Renal Disease Risk Gene: Controlling De Novo Lipogenesis in Kidney Tubules: FR-PO619 by Mukhi, Dhanunjay, Susztak, Katalin

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The key role of altered tubule cell lipid metabolism in kidney disease development by Lee, Lauren E, Doke, Tomohito, Mukhi, Dhanunjay, Susztak, Katalin

“…Kidney epithelial cells have very high energy requirements, which are largely met by fatty acid oxidation. Complex changes in lipid metabolism are observed in…”
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Wasp Homologue Associated with Membranes and Microtubules Is a Kidney Disease Risk Gene: PO2502 by Mukhi, Dhanunjay, Doke, Tomohito, Huang, Shizheng, Susztak, Katalin

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Changes in Gene Expression in Fatty Acid Metabolism and De Novo Lipogenesis Are Conserved in Human CKD and Animal Models: SA-OR96 by Lee, Lauren Elizabeth, Doke, Tomohito, Mukhi, Dhanunjay, Zeng, Li, Susztak, Katalin

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Growth hormone induces Notch1 signaling in podocytes and contributes to proteinuria in diabetic nephropathy by Nishad, Rajkishor, Mukhi, Dhanunjay, Tahaseen, Syed V., Mungamuri, Sathish Kumar, Pasupulati, Anil K.

“…Growth hormone (GH) plays a significant role in normal renal function and overactive GH signaling has been implicated in proteinuria in diabetes and…”
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An indispensable role for dynamin-related protein 1 in beige and brown adipogenesis by Mooli, Raja Gopal Reddy, Mukhi, Dhanunjay, Chen, Zhonghe, Buckner, Nia, Ramakrishnan, Sadeesh K

“…Emerging evidence indicates that proper mitochondrial dynamics are critical for adipocyte differentiation and functional thermogenic capacity. We found that…”
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Growth hormone induces transforming growth factor-β1 in podocytes: Implications in podocytopathy and proteinuria by Mukhi, Dhanunjay, Kolligundla, Lakshmi P, Maruvada, Saikrishna, Nishad, Rajkishor, Pasupulati, Anil K

“…Pituitary growth hormone (GH) is essential for growth, metabolism, and renal function. Overactive GH signaling is associated with impaired kidney function…”
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Stabilization of hypoxia‐inducible factor 1α by cobalt chloride impairs podocyte morphology and slit‐diaphragm function by Nakuluri, Krishnamurthy, Mukhi, Dhanunjay, Mungamuri, Sathish Kumar, Pasupulati, Anil Kumar

“…Glomerular podocytes are the major components of the renal filtration barrier, and altered podocyte permselectivity is a key event in the pathogenesis of…”
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APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis by Wu, Junnan, Ma, Ziyuan, Raman, Archana, Beckerman, Pazit, Dhillon, Poonam, Mukhi, Dhanunjay, Palmer, Matthew, Chen, Hua Chang, Cohen, Cassiane Robinson, Dunn, Thomas, Reilly, John P., Meyer, Nuala J., Shashaty, Michael G.S., Arany, Zoltan, Haskó, György, Laudanski, Krzysztof, Hung, Adriana, Susztak, Katalin

“…The incidence and severity of sepsis is higher among individuals of African versus European ancestry. We found that genetic risk variants (RVs) in the…”
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Podocyte derived TNF‐α mediates monocyte differentiation and contributes to glomerular injury by Nishad, Rajkishor, Mukhi, Dhanunjay, Kethavath, Srinivas, Raviraj, Sumathi, Paturi, Atreya S. V., Motrapu, Manga, Kurukuti, Sreenivasulu, Pasupulati, Anil Kumar

“…Diabetes shortens the life expectancy by more than a decade, and the excess mortality in diabetes is correlated with the incidence of kidney disease. Diabetic…”
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ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules by Mukhi, Dhanunjay, Li, Lingzhi, Liu, Hongbo, Doke, Tomohito, Kolligundla, Lakshmi P, Ha, Eunji, Kloetzer, Konstantin, Abedini, Amin, Mukherjee, Sarmistha, Wu, Junnan, Dhillon, Poonam, Hu, Hailong, Guan, Dongyin, Funai, Katsuhiko, Uehara, Kahealani, Titchenell, Paul M, Baur, Joseph A, Wellen, Kathryn E, Susztak, Katalin

“…Worldwide, over 800 million people are affected by kidney disease, yet its pathogenesis remains elusive, hindering the development of novel therapeutics. In…”
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Sustained mitochondrial biogenesis is essential to maintain caloric restriction-induced beige adipocytes by Mooli, Raja Gopal Reddy, Mukhi, Dhanunjay, Watt, Mikayla, Edmunds, Lia, Xie, Bingxian, Capooci, Joseph, Reslink, Matthew, Eze, Chetachukwu, Mills, Amanda, Stolz, Donna B., Jurczak, Michael, Ramakrishnan, Sadeesh K.

“…Caloric restriction (CR) delays the onset of metabolic and age-related disorders. Recent studies have demonstrated that formation of beige adipocytes induced…”
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