Diversity-oriented synthesis of analogues of the novel macrocyclic peptide FR-225497 through late stage functionalization

A concise synthetic approach to a class of biologically interesting cyclic tetrapeptides is reported which involves a late-stage functionalization of a macrocyclic scaffold through cross metathesis in an attempt to create diversity. The utility of this protocol is demonstrated through the preparatio...

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Bibliographic Details
Published in:	Beilstein journal of organic chemistry Vol. 11; no. 1; pp. 2487 - 2492
Main Authors:	Mukherjee, Jyotiprasad, Sil, Suman, Chattopadhyay, Shital Kumar
Format:	Journal Article
Language:	English
Published:	Germany Beilstein-Institut zur Föerderung der Chemischen Wissenschaften 08-12-2015 Beilstein-Institut
Subjects:	Chemistry cross metathesis cyclic peptides diversity oriented synthesis Full Research Paper macrocycle cyclic peptides macrocycle cross metathesis diversity oriented synthesis
Online Access:	Get full text
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Summary:	A concise synthetic approach to a class of biologically interesting cyclic tetrapeptides is reported which involves a late-stage functionalization of a macrocyclic scaffold through cross metathesis in an attempt to create diversity. The utility of this protocol is demonstrated through the preparation of three structural analogues of the important naturally occurring histone deacetylase inhibitor FR-225497.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1860-5397 2195-951X 1860-5397
DOI:	10.3762/bjoc.11.270