Studies of YB-1 protein in breast tumors

Studies of YB-1 protein in breast tumors

The multifunctional mammalian protein YB-1 is involved in multiple DNA- and mRNA-dependent events in the cell and regulates gene expression at different levels. The intracellular localization and relative mRNA content of YB-1 in the breast tumors were studied. The presence of cells with nuclear YB-1...

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Bibliographic Details
Published in:Klinicheskaia laboratornaia diagnostika no. 4; p. 21
Main Authors: Gens, G P, Stromskaia, T P, Kalita, O V, Vaĭman, A V, Rybalkina, E Iu, Ovchinnikov, L P, Sorokin, A V, Korobkova, L I, Astrakhantsev, A F, Mukha, S F, Moiseeva, N I, Stavrovskaia, A A
Format: Journal Article
Language:Russian
Published: Russia (Federation) 01-04-2009
Subjects:
Biomarkers, Tumor - metabolism
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cell Nucleus - metabolism
Cell Nucleus - pathology
Cytoplasm - metabolism
Cytoplasm - pathology
DNA-Binding Proteins - metabolism
Female
Humans
Immunohistochemistry
Middle Aged
Nuclear Proteins - metabolism
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - metabolism
Y-Box-Binding Protein 1
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Summary:The multifunctional mammalian protein YB-1 is involved in multiple DNA- and mRNA-dependent events in the cell and regulates gene expression at different levels. The intracellular localization and relative mRNA content of YB-1 in the breast tumors were studied. The presence of cells with nuclear YB-1 localization in the tumor cell population is a poor predictor that correlates with larger tumors (more than 5 cm). The high YB-1 mRNA content in the breast tumors promotes metastasis of small neoplasms and patients with breast cancer who have high tumor tissue YB-1 mRNA levels may referred to as an early distant metastasis risk group. The findings suggest that combined determination of YB-1 intercellular localization and mRNA levels can ensure a more reliable prognosis of breast cancer.
ISSN:0869-2084