Search Results - "Mukamel, Eran"

Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain by Mo, Alisa, Mukamel, Eran A., Davis, Fred P., Luo, Chongyuan, Henry, Gilbert L., Picard, Serge, Urich, Mark A., Nery, Joseph R., Sejnowski, Terrence J., Lister, Ryan, Eddy, Sean R., Ecker, Joseph R., Nathans, Jeremy

“…Neuronal diversity is essential for mammalian brain function but poses a challenge to molecular profiling. To address the need for tools that facilitate…”
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Statistical Deconvolution for Superresolution Fluorescence Microscopy by Mukamel, Eran A., Babcock, Hazen, Zhuang, Xiaowei

“…Superresolution microscopy techniques based on the sequential activation of fluorophores can achieve image resolution of ∼10 nm but require a sparse…”
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Multiple Comparisons and Inappropriate Statistical Testing Lead to Spurious Sex Differences in Gene Expression by Mukamel, Eran A.

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Single-Cell Sequencing of Brain Cell Transcriptomes and Epigenomes by Armand, Ethan J, Li, Junhao, Xie, Fangming, Luo, Chongyuan, Mukamel, Eran A

“…Single-cell sequencing technologies, including transcriptomic and epigenomic assays, are transforming our understanding of the cellular building blocks of…”
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Perspectives on defining cell types in the brain by Mukamel, Eran A, Ngai, John

“…•Cell types correspond to self-stabilizing regulatory networks that establish and maintain a core phenotypic program.•Single cell molecular profiling of…”
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Comprehensive analysis of single cell ATAC-seq data with SnapATAC by Fang, Rongxin, Preissl, Sebastian, Li, Yang, Hou, Xiaomeng, Lucero, Jacinta, Wang, Xinxin, Motamedi, Amir, Shiau, Andrew K., Zhou, Xinzhu, Xie, Fangming, Mukamel, Eran A., Zhang, Kai, Zhang, Yanxiao, Behrens, M. Margarita, Ecker, Joseph R., Ren, Bing

“…Identification of the cis-regulatory elements controlling cell-type specific gene expression patterns is essential for understanding the origin of cellular…”
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Automated Analysis of Cellular Signals from Large-Scale Calcium Imaging Data by Mukamel, Eran A., Nimmerjahn, Axel, Schnitzer, Mark J.

“…Recent advances in fluorescence imaging permit studies of Ca2+ dynamics in large numbers of cells, in anesthetized and awake behaving animals. However, unlike…”
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Single-cell methylomes identify neuronal subtypes and regulatory elements in mammalian cortex by Luo, Chongyuan, Keown, Christopher L., Kurihara, Laurie, Zhou, Jingtian, He, Yupeng, Li, Junhao, Castanon, Rosa, Lucero, Jacinta, Nery, Joseph R., Sandoval, Justin P., Bui, Brian, Sejnowski, Terrence J., Harkins, Timothy T., Mukamel, Eran A., Behrens, M. Margarita, Ecker, Joseph R.

“…The mammalian brain contains diverse neuronal types, yet we lack single-cell epigenomic assays that are able to identify and characterize them. DNA methylation…”
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Global Epigenomic Reconfiguration During Mammalian Brain Development by Lister, Ryan, Mukamel, Eran A., Nery, Joseph R., Urich, Mark, Puddifoot, Clare A., Johnson, Nicholas D., Lucero, Jacinta, Huang, Yun, Dwork, Andrew J., Schultz, Matthew D., Yu, Miao, Tonti-Filippini, Julian, Heyn, Holger, Hu, Shijun, Wu, Joseph C., Rao, Anjana, Esteller, Manel, He, Chuan, Haghighi, Fatemeh G., Sejnowski, Terrence J., Behrens, M. Margarita, Ecker, Joseph R.

“…DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning,…”
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Motor Behavior Activates Bergmann Glial Networks by Nimmerjahn, Axel, Mukamel, Eran A., Schnitzer, Mark J.

“…Although it is firmly established that neuronal activity is a prime determinant of animal behavior, relationships between astrocytic excitation and animal…”
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Human body epigenome maps reveal noncanonical DNA methylation variation by Schultz, Matthew D., He, Yupeng, Whitaker, John W., Hariharan, Manoj, Mukamel, Eran A., Leung, Danny, Rajagopal, Nisha, Nery, Joseph R., Urich, Mark A., Chen, Huaming, Lin, Shin, Lin, Yiing, Jung, Inkyung, Schmitt, Anthony D., Selvaraj, Siddarth, Ren, Bing, Sejnowski, Terrence J., Wang, Wei, Ecker, Joseph R.

“…As part of the Epigenome Roadmap Project, genome-wide maps of DNA methylation and transcriptomes together with genomic DNA sequencing of 18 different primary…”
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Electroencephalogram signatures of loss and recovery of consciousness from propofol by Purdon, Patrick L, Pierce, Eric T, Mukamel, Eran A, Prerau, Michael J, Walsh, John L, Wong, Kin Foon K, Salazar-Gomez, Andres F, Harrell, Priscilla G, Sampson, Aaron L, Cimenser, Aylin, Ching, ShiNung, Kopell, Nancy J, Tavares-Stoeckel, Casie, Habeeb, Kathleen, Merhar, Rebecca, Brown, Emery N

“…Unconsciousness is a fundamental component of general anesthesia (GA), but anesthesiologists have no reliable ways to be certain that a patient is unconscious…”
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Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus by Zhang, Tie-Yuan, Keown, Christopher L., Wen, Xianglan, Li, Junhao, Vousden, Dulcie A., Anacker, Christoph, Bhattacharyya, Urvashi, Ryan, Richard, Diorio, Josie, O’Toole, Nicholas, Lerch, Jason P., Mukamel, Eran A., Meaney, Michael J.

“…Early life experience influences stress reactivity and mental health through effects on cognitive-emotional functions that are, in part, linked to gene…”
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DNA methylation atlas of the mouse brain at single-cell resolution by Liu, Hanqing, Zhou, Jingtian, Tian, Wei, Luo, Chongyuan, Bartlett, Anna, Aldridge, Andrew, Lucero, Jacinta, Osteen, Julia K., Nery, Joseph R., Chen, Huaming, Rivkin, Angeline, Castanon, Rosa G., Clock, Ben, Li, Yang Eric, Hou, Xiaomeng, Poirion, Olivier B., Preissl, Sebastian, Pinto-Duarte, Antonio, O’Connor, Carolyn, Boggeman, Lara, Fitzpatrick, Conor, Nunn, Michael, Mukamel, Eran A., Zhang, Zhuzhu, Callaway, Edward M., Ren, Bing, Dixon, Jesse R., Behrens, M. Margarita, Ecker, Joseph R.

“…Mammalian brain cells show remarkable diversity in gene expression, anatomy and function, yet the regulatory DNA landscape underlying this extensive…”
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A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex by Yao, Zizhen, Liu, Hanqing, Xie, Fangming, Fischer, Stephan, Adkins, Ricky S., Aldridge, Andrew I., Ament, Seth A., Bartlett, Anna, Behrens, M. Margarita, Van den Berge, Koen, Bertagnolli, Darren, de Bézieux, Hector Roux, Biancalani, Tommaso, Booeshaghi, A. Sina, Bravo, Héctor Corrada, Casper, Tamara, Colantuoni, Carlo, Crabtree, Jonathan, Creasy, Heather, Crichton, Kirsten, Crow, Megan, Dee, Nick, Dougherty, Elizabeth L., Doyle, Wayne I., Dudoit, Sandrine, Fang, Rongxin, Felix, Victor, Fong, Olivia, Giglio, Michelle, Goldy, Jeff, Hawrylycz, Mike, Herb, Brian R., Hertzano, Ronna, Hou, Xiaomeng, Hu, Qiwen, Kancherla, Jayaram, Kroll, Matthew, Lathia, Kanan, Li, Yang Eric, Lucero, Jacinta D., Luo, Chongyuan, Mahurkar, Anup, McMillen, Delissa, Nadaf, Naeem M., Nery, Joseph R., Nguyen, Thuc Nghi, Niu, Sheng-Yong, Ntranos, Vasilis, Orvis, Joshua, Osteen, Julia K., Pham, Thanh, Pinto-Duarte, Antonio, Poirion, Olivier, Preissl, Sebastian, Purdom, Elizabeth, Rimorin, Christine, Risso, Davide, Rivkin, Angeline C., Smith, Kimberly, Street, Kelly, Sulc, Josef, Svensson, Valentine, Tieu, Michael, Torkelson, Amy, Tung, Herman, Vaishnav, Eeshit Dhaval, Vanderburg, Charles R., van Velthoven, Cindy, Wang, Xinxin, White, Owen R., Huang, Z. Josh, Kharchenko, Peter V., Pachter, Lior, Ngai, John, Regev, Aviv, Tasic, Bosiljka, Welch, Joshua D., Gillis, Jesse, Macosko, Evan Z., Ren, Bing, Ecker, Joseph R., Zeng, Hongkui, Mukamel, Eran A.

“…Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased samples of the diverse cell types in the brain 1 – 3 . With the…”
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Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness by Lewis, Laura D, Weiner, Veronica S, Mukamel, Eran A, Donoghue, Jacob A, Eskandar, Emad N, Madsen, Joseph R, Anderson, William S, Hochberg, Leigh R, Cash, Sydney S, Brown, Emery N, Purdon, Patrick L

“…The neurophysiological mechanisms by which anesthetic drugs cause loss of consciousness are poorly understood. Anesthetic actions at the molecular, cellular,…”
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An atlas of gene regulatory elements in adult mouse cerebrum by Li, Yang Eric, Preissl, Sebastian, Hou, Xiaomeng, Zhang, Ziyang, Zhang, Kai, Qiu, Yunjiang, Poirion, Olivier B., Li, Bin, Chiou, Joshua, Liu, Hanqing, Pinto-Duarte, Antonio, Kubo, Naoki, Yang, Xiaoyu, Fang, Rongxin, Wang, Xinxin, Han, Jee Yun, Lucero, Jacinta, Yan, Yiming, Miller, Michael, Kuan, Samantha, Gorkin, David, Gaulton, Kyle J., Shen, Yin, Nunn, Michael, Mukamel, Eran A., Behrens, M. Margarita, Ecker, Joseph R., Ren, Bing

“…The mammalian cerebrum performs high-level sensory perception, motor control and cognitive functions through highly specialized cortical and subcortical…”
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Cellular and genetic drivers of RNA editing variation in the human brain by Cuddleston, Winston H., Li, Junhao, Fan, Xuanjia, Kozenkov, Alexey, Lalli, Matthew, Khalique, Shahrukh, Dracheva, Stella, Mukamel, Eran A., Breen, Michael S.

“…Posttranscriptional adenosine-to-inosine modifications amplify the functionality of RNA molecules in the brain, yet the cellular and genetic regulation of RNA…”
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Maternal immune activation impairs cognitive flexibility and alters transcription in frontal cortex by Amodeo, Dionisio A., Lai, Chi-Yu, Hassan, Omron, Mukamel, Eran A., Behrens, M. Margarita, Powell, Susan B.

“…Epidemiological studies suggest that the risk of neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia is increased by prenatal…”
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Turning over DNA methylation in the mind by Lister, Ryan, Mukamel, Eran A

“…Cytosine DNA methylation is a stable epigenetic modification with established roles in regulating transcription, imprinting, female X-chromosome inactivation,…”
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