Search Results - "Mukai, Yuji"

Utilizing the dry spot method to monitor the concentrations of biologic agents in breast milk by Mukai, Yuji, Doki, Kosuke, Suzuki, Yoshiharu, Homma, Masato

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Simultaneous Quantification of BCR-ABL and Bruton Tyrosine Kinase Inhibitors in Dried Plasma Spots and Its Application to Clinical Sample Analysis by Mukai, Yuji, Yoshida, Yuka, Yoshida, Tatsunari, Kondo, Takeshi, Inotsume, Nobuo, Toda, Takaki

“…Recent reports highlight the importance of therapeutic drug monitoring (TDM) of BCR-ABL and Bruton tyrosine kinase inhibitors (TKIs); thus, large-scale studies…”
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An Liquid Chromatography–Tandem Mass Spectrometry Method for the Simultaneous Determination of Afatinib, Alectinib, Ceritinib, Crizotinib, Dacomitinib, Erlotinib, Gefitinib, and Osimertinib in Human Serum by Mukai, Yuji, Wakamoto, Azusa, Hatsuyama, Tae, Yoshida, Tatsunari, Sato, Hideki, Fujita, Akihisa, Inotsume, Nobuo, Toda, Takaki

“…Routine therapeutic drug monitoring is a promising approach for the rational use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and…”
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Development and Validation of a Simple Method for Simultaneously Measuring the Concentrations of BCR-ABL and Bruton Tyrosine Kinase Inhibitors in Dried Blood Spot (DBS): A Pilot Study to Obtain Candidate Conversion Equations for Predicting Plasma Concentration Based on DBS Concentration by Mukai, Yuji, Yoshida, Tatsunari, Kondo, Takeshi, Miura, Jun, Inotsume, Nobuo, Toda, Takaki

“…Dried blood spots (DBSs) are promising candidates for therapeutic drug monitoring. In this study, a simple method for the simultaneous measurement of tyrosine…”
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The Inhibitory Effect of Telmisartan on the Metabolism of Arachidonic Acid by CYP2C9 and CYP2C8: An in Vitro Study by Kato, Yuka, Mukai, Yuji, Rane, Anders, Inotsume, Nobuo, Toda, Takaki

“…Epoxyeicosatorienoic acids (EETs) are generated from arachidonic acid (AA) by CYPs. EETs comprise four regioisomers (14,15-, 11,12-, 8,9-, and 5,6-EET). EETs…”
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Interior Temperature and Relative Humidity of an Envelope During Mail Transport by the Japan Post in the Summer: Preliminary Study for a Stability Test of Dried Blood Spot Samples Sent as Regular Mail by Mukai, Yuji, Minami, Rumiko, Doki, Kosuke, Inotsume, Nobuo, Toda, Takaki

“…The dried blood spot (DBS) is well studied and has been considered a useful technique for collecting biological specimens for therapeutic drug monitoring…”
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Effects of angiotensin II receptor blockers on serum levels of epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids in patients admitted to a cardiovascular center by Kato, Yuka, Senda, Asuna, Mukai, Yuji, Yamashita, Miki, Sasaoka, Yuki, Hanada, Minayo, Hongo, Fuminori, Hirokami, Mitsugu, Rane, Anders, Inotsume, Nobuo, Toda, Takaki

“…Purpose Several clinical studies have demonstrated that angiotensin-converting enzyme inhibitors, but not angiotensin II receptor blockers (ARBs), reduce the…”
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Co-administration of Fluvastatin and CYP3A4 and CYP2C8 Inhibitors May Increase the Exposure to Fluvastatin in Carriers of CYP2C9 Genetic Variants by Mukai, Yuji, Narita, Masayuki, Akiyama, Erika, Ohashi, Kanami, Horiuchi, Yasutaka, Kato, Yuka, Toda, Takaki, Rane, Anders, Inotsume, Nobuo

“…Fluvastatin, which is one of the hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins), is primarily metabolized by CYP2C9 and to a lesser extent…”
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Correction to: Effects of angiotensin II receptor blockers on serum levels of epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids in patients admitted to a cardiovascular center by Kato, Yuka, Senda, Asuna, Mukai, Yuji, Yamashita, Miki, Sasaoka, Yuki, Hanada, Minayo, Hongo, Fuminori, Hirokami, Mitsugu, Rane, Anders, Inotsume, Nobuo, Toda, Takaki

“…A Correction to this paper has been published: https://doi.org/10.1007/s00228-021-03092-2…”
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Concentration of Sulfate and Glucuronide Conjugates of Ritodrine in Twin Pregnancy by Soma, Mayuko, Konda, Ainari, Fujieda, Satoko, Sasaki, Yoichi, Keira, Mitsuaki, Yoshida, Hiroshi, Mukai, Yuji, Toda, Takaki, Inotsume, Nobuo

“…Ritodrine, a drug for the treatment of threatened premature labor, is a highly selective beta-2 agonist with the major metabolites of sulfate and glucuronide…”
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Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8 by Senda, Asuna, Mukai, Yuji, Toda, Takaki, Hayakawa, Toru, Yamashita, Miki, Eliasson, Erik, Rane, Anders, Inotsume, Nobuo

“…Arachidonic acid (AA) is metabolized to epoxyeicosatrienoic acids (EETs) via cytochrome enzymes such as CYP 2C9, 2C8 and 2J2. EETs play a role in…”
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Losartan Competitively Inhibits CYP2C8-Dependent Paclitaxel Metabolism in Vitro by Mukai, Yuji, Toda, Takaki, Hayakawa, Toru, Eliasson, Erik, Rane, Anders, Inotsume, Nobuo

“…The present study aimed to characterize the inhibitory effects of losartan, an angiotensin II receptor blocker, on CYP2C8. Inhibition experiments were based on…”
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Simultaneous Determination Method of Epoxyeicosatrienoic Acids and Dihydroxyeicosatrienoic Acids by LC-MS/MS System by Mukai, Yuji, Toda, Takaki, Takeuchi, Satoya, Senda, Asuna, Yamashita, Miki, Eliasson, Erik, Rane, Anders, Inotsume, Nobuo

“…Epoxyeicosatrienoic acids (EETs) are produced primarily by CYPs from arachidonic acid (AA) and then further metabolized to the corresponding…”
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Angiotensin II Receptor Blockers Inhibit the Generation of Epoxyeicosatrienoic Acid from Arachidonic Acid in Recombinant CYP2C9, CYP2J2 and Human Liver Microsomes by Senda, Asuna, Mukai, Yuji, Hayakawa, Toru, Kato, Yuka, Eliasson, Erik, Rane, Anders, Toda, Takaki, Inotsume, Nobuo

“…Cytochrome P450 (CYP) 2C9, CYP2C8 and CYP2J2 enzymes, which metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids, have cardioprotective effects…”
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The Role of CYP2C8 and CYP2C9 Genotypes in Losartan‐Dependent Inhibition of Paclitaxel Metabolism in Human Liver Microsomes by Mukai, Yuji, Senda, Asuna, Toda, Takaki, Eliasson, Erik, Rane, Anders, Inotsume, Nobuo

“…The aim of the present study was to further investigate a previously identified metabolic interaction between losartan and paclitaxel, which is one of the…”
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Novel high-performance liquid chromatography–tandem mass spectrometry method for simultaneous quantification of BCR-ABL and Bruton’s tyrosine kinase inhibitors and their three active metabolites in human plasma by Mukai, Yuji, Yoshida, Tatsunari, Kondo, Takeshi, Inotsume, Nobuo, Toda, Takaki

“…•Method for simultaneous determination of six TKIs and three metabolites in plasma.•A simple extraction procedure is required.•The method is applicable to the…”
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An analytical method using salting‐out assisted liquid–liquid extraction to quantify ceftriaxone from micro volumes of human serum by Mukai, Yuji, Sugii, Narushi, Doki, Kosuke, Homma, Masato

“…Ceftriaxone (CTRX) is a commonly used cephalosporin antibiotic. It is suggested that monitoring plasma/serum concentrations is helpful for its safe use. This…”
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Pharmacokinetic study of erlotinib in a pregnant woman with advanced non‐small cell lung cancer and observation of the effects on the child growth by Aida, Yuka, Ohgami, Masahiro, Mukai, Yuji, Matsuyama, Masashi, Obata‐Yasuoka, Mana, Satoh, Toyomi, Homma, Masato, Sekine, Ikuo, Hizawa, Nobuyuki

“…Aims The aim of the study is to report the clinical and pharmacological observations from a pregnant patient treated with erlotinib in the second and third…”
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An LC-MS/MS method for the simultaneous determination of afatinib, alectinib, ceritinib, crizotinib, dacomitinib, erlotinib, gefitinib, and osimertinib in human serum by Mukai, Yuji, Wakamoto, Azusa, Hatsuyama, Tae, Yoshida, Tatsunari, Sato, Hideki, Fujita, Akihisa, Inotsume, Nobuo, Toda, Takaki

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Combined effect of telmisartan and fluvastatin on arachidonic acid metabolism in human liver microsomes by Kato, Yuka, Mukai, Yuji, Rane, Anders, Inotsume, Nobuo, Toda, Takaki

“…1. Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid (AA) via cytochrome P450s, have a protective effect on the cardiovascular system involving…”
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