Search Results - "Muir, W. J."

Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a Family by Blackwood, D.H.R., Fordyce, A., Walker, M.T., St. Clair, D.M., Porteous, D.J., Muir, W.J.

“…A family with a (1;11)(q42;q14.3) translocation significantly linked to a clinical phenotype that includes schizophrenia and affective disorders is described…”
Get full text

Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the scottish population by THOMSON, P. A, WRAY, N. R, MILLAR, J. K, EVANS, K. L, LE HELLARD, S, CONDIE, A, MUIR, W. J, BLACKWOOD, D. H. R, PORTEOUS, D. J

“…The Translin-associated factor X/Disrupted in Schizophrenia 1 (TRAX/DISC) region was first implicated as a susceptibility locus for schizophrenia by analysis…”
Get full text

The experiences of adults with intellectual disabilities and their carers in general hospitals: a focus group study by Gibbs, S. M., Brown, M. J., Muir, W. J.

“…Background  People with intellectual disabilities (ID) have higher levels of health needs compared with the general population, many of which are unrecognised…”
Get full text

Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder by PICKARD, B. S, MALLOY, M. P, CHRISTOFOROU, A, THOMSON, P. A, EVANS, K. L, MORRIS, S. W, HAMPSON, M, PORTEOUS, D. J, BLACKWOOD, D. H. R, MUIR, W. J

“…In the search for the biological causes of schizophrenia and bipolar disorder, glutamate neurotransmission has emerged as one of a number of candidate…”
Get full text

Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder by Pickard, B S, Christoforou, A, Thomson, P A, Fawkes, A, Evans, K L, Morris, S W, Porteous, D J, Blackwood, D H, Muir, W J

“…The neuronal PAS domain 3 ( NPAS3 ) gene encodes a neuronal transcription factor that is implicated in psychiatric disorders by the identification of a human…”
Get full text

Association of Neuregulin 1 with schizophrenia and bipolar disorder in a second cohort from the Scottish population by THOMSON, P. A, CHRISTOFOROU, A, MORRIS, S. W, ADIE, E, PICKARD, B. S, PORTEOUS, D. J, MUIR, W. J, BLACKWOOD, D. H. R, EVANS, K. L

“…Neuregulin 1 (NRG1) is a strong candidate for involvement in the aetiology of schizophrenia. A haplotype, initially identified as showing association in the…”
Get full text

Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p by Christoforou, A, McGhee, K A, Morris, S W, Thomson, P A, Anderson, S, McLean, A, Torrance, H S, Le Hellard, S, Pickard, B S, StClair, D, Muir, W J, Blackwood, D H, Porteous, D J, Evans, K L

Get full text

A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42 by MACGREGOR, S, VISSCHER, P. M, KNOTT, S. A, THOMSON, P, PORTEOUS, D. J, MILLAR, J. K, DEVON, R. S, BLACKWOOD, D, MUIR, W. J

“…In this study, we report a genome scan for psychiatric disease susceptibility loci in 13 Scottish families. We follow up one of the linkage peaks on chromosome…”
Get full text

Disruption of the neuronal PAS3 gene in a family affected with schizophrenia by Kamnasaran, D, Muir, W J, Ferguson-Smith, M A, Cox, D W

“…Schizophrenia and its subtypes are part of a complex brain disorder with multiple postulated aetiologies. There is evidence that this common disease is…”
Get full text

Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3 by Sha, L, MacIntyre, L, Machell, J A, Kelly, M P, Porteous, D J, Brandon, N J, Muir, W J, Blackwood, D H, Watson, D G, Clapcote, S J, Pickard, B S

“…The basic helix-loop-helix PAS (Per, Arnt, Sim) domain transcription factor gene NPAS3 is a replicated genetic risk factor for psychiatric disorders. A…”
Get full text

Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia by MILLAR, J. K, CHRISTIE, S, ANDERSON, S, LAWSON, D, LOH, D. Hsiao-Wei, DEVON, R. S, ARVEILER, B, MUIR, W. J, BLACKWOOD, D. H. R, PORTEOUS, D. J

“…Two overlapping and antiparallel genes on chromosome 1, Disrupted In Schizophrenia 1 and 2 (DISC1 and DISC2), are disrupted by a (1;11)(q42.1;q14.3)…”
Get full text

Dimensions and classes of psychosis in a population cohort: a four-class, four-dimension model of schizophrenia and affective psychoses by Murray, V, McKee, I, Miller, P M, Young, D, Muir, W J, Pelosi, A J, Blackwood, D H R

“…Classification of psychosis lacks a biological basis and current diagnostic categories may obscure underlying continuities. Data reduction methods of symptom…”
Get more information

Chromosomal abnormalities and mental illness by MACINTYRE, D. J, BLACKWOOD, D. H. R, PORTEOUS, D. J, PICKARD, B. S, MUIR, W. J

“…Linkage studies of mental illness have provided suggestive evidence of susceptibility loci over many broad chromosomal regions. Pinpointing causative gene…”
Get full text

Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia by CHRISTOFOROU, A, LE HELLARD, S, EVANS, K. L, THOMSON, P. A, MORRIS, S. W, TENESA, A, PICKARD, B. S, WRAY, N. R, MUIR, W. J, BLACKWOOD, D. H, PORTEOUS, D. J

“…Several independent linkage studies have identified chromosome 4p15-p16 as a putative region of susceptibility for bipolar disorder (BP), schizophrenia (SCZ)…”
Get full text

Menopausal Experiences of Women with Intellectual Disabilities by Willis, D. S., Wishart, J. G., Muir, W. J.

“…Background  Little is known about the menopause in women with intellectual disabilities (ID) save that its onset is earlier than in the general population, and…”
Get full text

The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia by DEVON, R. S, ANDERSON, S, TEAGUE, P. W, MUIR, W. J, MURRAY, V, PELOSI, A. J, BLACKWOOD, D. H. R, PORTEOUS, D. J

“…The G-protein coupled metabotropic glutamate receptors (GRMs/mGluRs) have been implicated in the aetiology of schizophrenia as they modulate the NMDA response…”
Get full text

A GRIK4 variant conferring protection against bipolar disorder modulates hippocampal function by Whalley, H C, Pickard, B S, McIntosh, A M, Zuliani, R, Johnstone, E C, Blackwood, D H R, Lawrie, S M, Muir, W J, Hall, J

Get full text

'Pfropfschizophrenie' revisited. Schizophrenia in people with mild learning disability by Doody, G A, Johnstone, E C, Sanderson, T L, Owens, D G, Muir, W J

“…It is reported that people with mild learning disability have a higher point prevalence of schizophrenia than the normal population, the reasons for which are…”
Get more information

Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia by Underwood, S L, Christoforou, A, Thomson, P A, Wray, N R, Tenesa, A, Whittaker, J, Adams, R A, Le Hellard, S, Morris, S W, Blackwood, D H R, Muir, W J, Porteous, D J, Evans, K L

“…The orphan G protein-coupled receptor 78 (GPR78) gene lies within a region of chromosome 4p where we have previously shown linkage to bipolar affective…”
Get full text

Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo by Sullivan, P F, de Geus, E J C, Willemsen, G, James, M R, Smit, J H, Zandbelt, T, Arolt, V, Baune, B T, Blackwood, D, Cichon, S, Coventry, W L, Domschke, K, Farmer, A, Fava, M, Gordon, S D, He, Q, Heath, A C, Heutink, P, Holsboer, F, Hoogendijk, W J, Hottenga, J J, Hu, Y, Kohli, M, Lin, D, Lucae, S, MacIntyre, D J, Maier, W, McGhee, K A, McGuffin, P, Montgomery, G W, Muir, W J, Nolen, W A, Nöthen, M M, Perlis, R H, Pirlo, K, Posthuma, D, Rietschel, M, Rizzu, P, Schosser, A, Smit, A B, Smoller, J W, Tzeng, J-Y, van Dyck, R, Verhage, M, Zitman, F G, Martin, N G, Wray, N R, Boomsma, D I, Penninx, B W J H

“…Major depressive disorder (MDD) is a common complex trait with enormous public health significance. As part of the Genetic Association Information Network…”
Get full text