Search Results - "Muir, Kyle W"

The structural basis for cohesin–CTCF-anchored loops by Li, Yan, Haarhuis, Judith H. I., Sedeño Cacciatore, Ángela, Oldenkamp, Roel, van Ruiten, Marjon S., Willems, Laureen, Teunissen, Hans, Muir, Kyle W., de Wit, Elzo, Rowland, Benjamin D., Panne, Daniel

“…Cohesin catalyses the folding of the genome into loops that are anchored by CTCF 1 . The molecular mechanism of how cohesin and CTCF structure the 3D genome…”
Get full text

Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome by Yatskevich, Stanislau, Muir, Kyle W, Bellini, Dom, Zhang, Ziguo, Yang, Jing, Tischer, Thomas, Predin, Masa, Dendooven, Tom, McLaughlin, Stephen H, Barford, David

“…Kinetochores assemble onto specialized centromeric CENP-A (centromere protein A) nucleosomes (CENP-A ) to mediate attachments between chromosomes and the…”
Get full text

Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP by Naydenova, Katerina, Muir, Kyle W., Wu, Long-Fei, Zhang, Ziguo, Coscia, Francesca, Peet, Mathew J., Castro-Hartmann, Pablo, Qian, Pu, Sader, Kasim, Dent, Kyle, Kimanius, Dari, Sutherland, John D., Löwe, Jan, Barford, David, Russo, Christopher J.

“…The RNA polymerase inhibitor favipiravir is currently in clinical trials as a treatment for infection with severe acute respiratory syndrome coronavirus 2…”
Get full text

FOXM1: From cancer initiation to progression and treatment by Koo, Chuay-Yeng, Muir, Kyle W., Lam, Eric W.-F.

“…The Forkhead box protein M1 (FOXM1) transcription factor is a regulator of myriad biological processes, including cell proliferation, cell cycle progression,…”
Get full text

Structural basis for Scc3-dependent cohesin recruitment to chromatin by Li, Yan, Muir, Kyle W, Bowler, Matthew W, Metz, Jutta, Haering, Christian H, Panne, Daniel

“…The cohesin ring complex is required for numerous chromosomal transactions including sister chromatid cohesion, DNA damage repair and transcriptional…”
Get full text

Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function by Muir, Kyle W., Kschonsak, Marc, Li, Yan, Metz, Jutta, Haering, Christian H., Panne, Daniel

“…Sister chromatid cohesion is a fundamental prerequisite to faithful genome segregation. Cohesion is precisely regulated by accessory factors that modulate the…”
Get full text

Phosphorylation of FOXO3a on Ser-7 by p38 Promotes Its Nuclear Localization in Response to Doxorubicin by Ho, Ka-Kei, McGuire, Victoria A., Koo, Chuay-Yeng, Muir, Kyle W., de Olano, Natalia, Maifoshie, Evie, Kelly, Douglas J., McGovern, Ursula B., Monteiro, Lara J., Gomes, Ana R., Nebreda, Angel R., Campbell, David G., Arthur, J. Simon C., Lam, Eric W.-F.

“…FOXO3a is a forkhead transcription factor that regulates a multitude of important cellular processes, including proliferation, apoptosis, differentiation, and…”
Get full text

Conserved and divergent mechanisms of inner kinetochore assembly onto centromeric chromatin by Yatskevich, Stanislau, Barford, David, Muir, Kyle W.

“…Kinetochores are large protein complexes built on centromeric chromatin that mediate chromosome segregation. The inner kinetochore, or constitutive…”
Get full text

The structure of the cohesin ATPase elucidates the mechanism of SMC–kleisin ring opening by Muir, Kyle W., Li, Yan, Weis, Felix, Panne, Daniel

“…Genome regulation requires control of chromosome organization by SMC–kleisin complexes. The cohesin complex contains the Smc1 and Smc3 subunits that associate…”
Get full text

Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules by Muir, Kyle W, Batters, Christopher, Dendooven, Tom, Yang, Jing, Zhang, Ziguo, Burt, Alister, Barford, David

“…Kinetochores couple chromosomes to the mitotic spindle to segregate the genome during cell division. An error correction mechanism drives the turnover of…”
Get full text

Structural basis of centromeric cohesion protection by García-Nieto, Alberto, Patel, Amrita, Li, Yan, Oldenkamp, Roel, Feletto, Leonardo, Graham, Joshua J., Willems, Laureen, Muir, Kyle W., Panne, Daniel, Rowland, Benjamin D.

“…In the early stages of mitosis, cohesin is released from chromosome arms but not from centromeres. The protection of centromeric cohesin by SGO1 maintains the…”
Get full text