Search Results - "Muir, K. T."

Remifentanil by bolus injection: a safety, pharmacokinetic, pharmacodynamic, and age effect investigation in human volunteers by Egan, T.D., Kern, S.E., Muir, K.T., White, J

“…Although remifentanil's short-acting pharmacokinetic profile makes it well suited for procedures during which a brief period of intense analgesia is required,…”
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Measured context-sensitive half-times of remifentanil and alfentanil by KAPILA, A, GLASS, P. S. A, JACOBS, J. R, MUIR, K. T, HERMANN, D. J, SHIRAISHI, M, HOWELL, S, SMITH, R. L

“…The context-sensitive half-time, rather than the terminal elimination half-life, has been proposed as a more clinically relevant measure of decreasing drug…”
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Remifentanil versus alfentanil : Comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers by EGAN, T. D, MINTO, C. F, HERMANN, D. J, BARR, J, MUIR, K. T, SHAFER, S. L

“…Remifentanil is an esterase-metabolized opioid with a rapid clearance. The aim of this study was to contrast the pharmacokinetics and pharmacodynamics of…”
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The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers by EGAN, T. D, LEMMENS, H. J. M, FISET, P, HERMANN, D. J, MUIR, K. T, STANSKI, D. R, SHAFER, S. L

“…Remifentanil (GI87084B) is a new short-acting opioid with a unique ester structure. Metabolism of remifentanil by ester hydrolysis results in very rapid…”
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Pharmacokinetics of remifentanil (GI87084B) and its major metabolite (GI90291) in patients undergoing elective inpatient surgery by WESTMORELAND, C. L, HOKE, J. F, SEBEL, P. S, HUG, C. C, MUIR, K. T

“…Remifentanil is a highly potent opioid with a rapid onset and a short duration of action due to its rapid hydrolysis by esterases in blood and tissues. The…”
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Pharmacokinetics and pharmacodynamics of remifentanil in persons with renal failure compared with healthy volunteers by HOKE, J. F, SHLUGMAN, D, GLASS, P. S. A, DERSHWITZ, M, MICHAŁOWSKI, P, MALTHOUSE-DUFORE, S, CONNORS, P. M, MARTEL, D, ROSOW, C. E, MUIR, K. T, RUBIN, N

“…Remifentanil is an opioid analgesic for use in anesthesia. An ester linkage renders it susceptible to rapid metabolism by blood and tissue esterases. Thus it…”
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Pharmacokinetics and pharmacodynamics of remifentanil in volunteer subjects with severe liver disease by DERSHWITZ, M, HOKE, J. F, ROSOW, C. E, MICHAŁOWSKI, P, CONNORS, P. M, MUIR, K. T, DIENSTAG, J. L

“…Remifentanil, a new mu-opioid agonist with an extremely short duration of action, is metabolized by circulating and tissue esterases; therefore, its clearance…”
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Metabolism of remifentanil during liver transplantation by Navapurkar, V U, Archer, S, Gupta, S K, Muir, K T, Frazer, N, Park, G R

“…We have investigated the pharmacokinetics of remifentanil and its less potent metabolite, GR90291, in six adult patients undergoing orthotopic liver…”
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The comparative pharmacodynamics of Remifentanil and its metabolite, GR90291, in a rat electroencephalographic model by COX, E. H, LANGEMEIJER, M. W. E, GUBBENS-STIBBE, J. M, MUIR, K. T, DANHOF, M

“…The purpose of this study was to investigate the in vivo pharmacodynamics and the pharmacodynamic interactions of remifentanil and its major metabolite,…”
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Influence of arteriovenous sampling on remifentanil pharmacokinetics and pharmacodynamics by Hermann, David J., Egan, Talmage D., Muir, Keith T.

“…Introduction Remifentanil is a new, short‐acting, rapidly metabolized opioid. Because remifentanil is metabolized in blood and tissues by nonspecific…”
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Pharmacokinetics of Remifentanil in Anesthetized Pediatric Patients Undergoing Elective Surgery or Diagnostic Procedures by Ross, Allison Kinder, Davis, Peter J., Dear, Guy deL, Ginsberg, Brian, McGowan, Francis X., Stiller, Richard D., Henson, Lynn Graham, Huffman, Cameron, Muir, Keith T.

“…Remifentanil hydrochloride is an ultra-short-acting opioid that undergoes rapid metabolism by tissue and plasma esterases. We aimed to characterize the…”
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Evaluating a possible pharmacokinetic interaction between remifentanil and esmolol in the rat by Haidar, S H, Moreton, J E, Liang, Z, Hoke, J F, Muir, K T, Eddington, N D

“…Remifentanil (Ultiva) is a novel, ultra-short-acting opioid which has recently been approved for use as an analgesic during induction and maintenance of…”
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Remifentanil pharmacokinetics in obese versus lean patients by Egan, T D, Huizinga, B, Gupta, S K, Jaarsma, R L, Sperry, R J, Yee, J B, Muir, K T

“…Remifentanil is a short-acting opioid whose pharmacokinetics have been characterized in detail. However, the impact of obesity on remifentanil pharmacokinetics…”
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The pharmacokinetics and electroencephalogram response of remifentanil alone and in combination with esmolol in the rat by HAIDAR, S. H, MORETON, J. E, LIANG, Z, HOKE, J. F, MUIR, K. T, EDDINGTON, N. D

“…The goal of this study was to determine if the co-administration of esmolol (ES), a short acting cardioselective beta-blocker, significantly alters the…”
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Remifentanil and Pulmonary Extraction During and After Cardiac Anesthesia by Duthie, David J. R, Stevens, Jan J. W. M, Doyle, Anthony R, Baddoo, Henry H. K, Gupta, Samir K, Muir, Keith T, Kirkham, Andrew J. T

“…We measured the apparent blood clearance and pulmonary extraction ratio of remifentanil in 10 adult patients undergoing elective myocardial revascularization…”
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Remacemide by Muir, K T, Palmer, G C

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Comparative pharmacokinetics and pharmacodynamics of remifentanil, its principle metabolite (GR90291) and alfentanil in dogs by Hoke, J F, Cunningham, F, James, M K, Muir, K T, Hoffman, W E

“…Remifentanil is an esterase-metabolized opioid developed for use in anesthesia. The principal metabolite of remifentanil, GR90291, is considered to be less…”
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Histamine Concentrations and Hemodynamic Responses After Remifentamil by Sebel, Peter S., Hoke, John F., Westmoreland, Cheryl, Hug, Carl C., Muir, Keith T., Szlam, Fania

“…Remifentanil is a new potent opioid analgesic that undergoes rapid esterase metabolism.The purpose of this study was to investigate hemodynamic responses to…”
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High-performance liquid chromatographic method for the determination of labetalol in plasma using ultraviolet detection by Hidalgo, I J, Muir, K T

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Analysis of amiodarone and desethylamiodarone in serum and tears by reversed-phase high-performance liquid chromatography by Muir, K T, Kook, K A, Stern, C, Gardner, K M

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