Use of a gonadotropin releasing hormone agonist implant as an alternative for surgical castration in male ferrets ( Mustela putorius furo)

Use of a gonadotropin releasing hormone agonist implant as an alternative for surgical castration in male ferrets ( Mustela putorius furo)

Surgical castration in ferrets has been implicated as an etiological factor in the development of hyperadrenocorticism in this species due to a castration-related increase in plasma gonadotropins. In search for a suitable alternative, the effect of treatment with the depot GnRH-agonist implant, desl...

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Bibliographic Details
Published in:Theriogenology Vol. 70; no. 2; pp. 161 - 167
Main Authors: Schoemaker, N.J., van Deijk, R., Muijlaert, B., Kik, M.J.L., Kuijten, A.M., de Jong, F.H., Trigg, T.E., Kruitwagen, C.L.J.J., Mol, J.A.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 15-07-2008
[Oxford]: Butterworth-Heinemann; [New York]: Elsevier Science
Subjects:
animal reproduction
Animals
castration
Contraceptive Agents, Male - administration & dosage
Contraceptive Agents, Male - pharmacology
Deslorelin
drug implants
Ferrets
Follicle Stimulating Hormone - blood
GnRH
Gonadotropin
gonadotropin-releasing hormone
gonadotropins
hormone agonists
hyperadrenocorticism
Male
males
Odorants
Orchiectomy - veterinary
Prostheses and Implants
Spermatogenesis
Testis - cytology
Testis - drug effects
Testosterone
Testosterone - blood
Time Factors
Triptorelin Pamoate - administration & dosage
Triptorelin Pamoate - analogs & derivatives
Triptorelin Pamoate - pharmacology
Deslorelin
Testosterone
Gonadotropin
GnRH
Spermatogenesis
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Summary:Surgical castration in ferrets has been implicated as an etiological factor in the development of hyperadrenocorticism in this species due to a castration-related increase in plasma gonadotropins. In search for a suitable alternative, the effect of treatment with the depot GnRH-agonist implant, deslorelin, on plasma testosterone concentrations and concurrent testes size, spermatogenesis, and the typical musky odor of intact male ferrets was investigated. Twenty-one male ferrets, equally divided into three groups, were either surgically castrated, received a slow release deslorelin implant or received a placebo implant. Plasma FSH and testosterone concentrations, testis size and spermatogenesis were all suppressed after the use of the deslorelin implant. The musky odor in the ferrets which had received a deslorelin implant was less compared to the ferrets which were either surgically castrated or had received a placebo implant. These results indicate that the deslorelin implant effectively prevents reproduction and the musky odor of intact male ferrets and is therefore considered a suitable alternative for surgical castration in these animals.
Bibliography:http://dx.doi.org/10.1016/j.theriogenology.2008.03.006
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0093-691X
1879-3231
DOI:10.1016/j.theriogenology.2008.03.006