Comparison of serum creatinine, cystatin c, and neutrophil gelatinase-associated lipocalin for acute kidney injury occurrence according to risk, injury, failure, loss, and end-stage criteria classification system in early after living kidney donation
To evaluate the kidney function after living kidney donation, we measured serum creatinine (SCr), cystatin C, and neutrophil gelatinase-associated lipocalin (NGAL) of 42 living donors before uninephrectomy and in three immediate days after it. We also evaluated the prevalence of the occurrence of th...
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| Published in: | Saudi journal of kidney diseases and transplantation Vol. 27; no. 4; pp. 659 - 664 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Riyadh, Saudi Arabia
Saudi Center for Organ Transplantation
01-07-2016
Wolters Kluwer - Medknow Publications Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | To evaluate the kidney function after living kidney donation, we measured serum
creatinine (SCr), cystatin C, and neutrophil gelatinase-associated lipocalin (NGAL) of 42 living
donors before uninephrectomy and in three immediate days after it. We also evaluated the
prevalence of the occurrence of the different stages of acute kidney injury (AKI) classified
according to risk, injury, failure, loss, and end-stage (RIFLE) criteria, and accuracy of each of
these three biomarkers for predicting them were evaluated. Significant serum NGAL (s-NGAL)
changes were limited to the 1st day after donation, whereas SCr and cystatin C changes continued
to the third day after donation. s-NGAL level in the 1st day and serum cystatin C in the 3rd day
after donation, respectively, had the largest area under curve and best sensitivity and
specificity for Stage 1 (risk) AKI prediction. During the immediate three days after donation,
about half of patients suffered from AKI; mostly Stage 1 (injury). The sequence of the emergence
of s-NGAL and s-cystatin C in the 1st and 3rd days as biomarkers with highest accuracy and power
for RIFLE criteria defined AKI stage discrimination in our study was comparable to previous
studies. We conclude that our study suggests that AKI was best detected in the 1st day after
uninephrectomy by the s-NGAL levels, whereas cystatin C was the best in the 3rd day after
donation for detection of AKI. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1319-2442 2320-3838 |
| DOI: | 10.4103/1319-2442.185220 |