Search Results - "Muglia, P"

α-5 α-3 nicotinic receptor subunit alleles increase risk for heavy smoking by Berrettini, W, Yuan, X, Tozzi, F, Song, K, Francks, C, Chilcoat, H, Waterworth, D, Muglia, P, Mooser, V

“…Twin studies indicate that additive genetic effects explain most of the variance in nicotine dependence (ND), a construct emphasizing habitual heavy smoking…”
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Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts by Muglia, P, Tozzi, F, Galwey, N W, Francks, C, Upmanyu, R, Kong, X Q, Antoniades, A, Domenici, E, Perry, J, Rothen, S, Vandeleur, C L, Mooser, V, Waeber, G, Vollenweider, P, Preisig, M, Lucae, S, Müller-Myhsok, B, Holsboer, F, Middleton, L T, Roses, A D

“…Major depressive disorder (MDD) is a highly prevalent disorder with substantial heritability. Heritability has been shown to be substantial and higher in the…”
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Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder by Chen, D T, Jiang, X, Akula, N, Shugart, Y Y, Wendland, J R, Steele, C J M, Kassem, L, Park, J-H, Chatterjee, N, Jamain, S, Cheng, A, Leboyer, M, Muglia, P, Schulze, T G, Cichon, S, Nöthen, M M, Rietschel, M, McMahon, F J

“…Meta-analyses of bipolar disorder (BD) genome-wide association studies (GWAS) have identified several genome-wide significant signals in European-ancestry…”
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Association of DISC1 and TSNAX genes and affective disorders in the depression case–control (DeCC) and bipolar affective case–control (BACCS) studies by Schosser, A, Gaysina, D, Cohen-Woods, S, Chow, P C, Martucci, L, Craddock, N, Farmer, A, Korszun, A, Gunasinghe, C, Gray, J, Jones, L, Tozzi, F, Perry, J, Muglia, P, Owen, M J, Craig, I W, McGuffin, P

“…The gene known as Disrupted-in-Schizophrenia-1, DISC1 , was originally discovered in a large family, in which it also co-segregated with bipolar affective…”
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Neuropsychological effects of the CSMD1 genome‐wide associated schizophrenia risk variant rs10503253 by Donohoe, G., Walters, J., Hargreaves, A., Rose, E.J., Morris, D.W., Fahey, C., Bellini, S., Cummins, E., Giegling, I., Hartmann, A.M., Möller, H.‐J., Muglia, P., Owen, M.J., Gill, M., O'Donovan, M.C., Tropea, D., Rujescu, D., Corvin, A.

“…The single‐nucleotide polymorphism (SNP) rs10503253, located within the CUB and Sushi multiple domains‐1 (CSMD1) gene on 8p23.2, was recently identified as…”
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Population-based linkage analysis of schizophrenia and bipolar case-control cohorts identifies a potential susceptibility locus on 19q13 by Francks, C, Tozzi, F, Farmer, A, Vincent, J B, Rujescu, D, St Clair, D, Muglia, P

“…Population-based linkage analysis is a new method for analysing genomewide single nucleotide polymorphism ( SNP ) genotype data in case–control samples, which…”
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Estimating the heritability of reporting stressful life events captured by common genetic variants by Power, R A, Wingenbach, T, Cohen-Woods, S, Uher, R, Ng, M Y, Butler, A W, Ising, M, Craddock, N, Owen, M J, Korszun, A, Jones, L, Jones, I, Gill, M, Rice, J P, Maier, W, Zobel, A, Mors, O, Placentino, A, Rietschel, M, Lucae, S, Holsboer, F, Binder, E B, Keers, R, Tozzi, F, Muglia, P, Breen, G, Craig, I W, Müller-Myhsok, B, Kennedy, J L, Strauss, J, Vincent, J B, Lewis, C M, Farmer, A E, McGuffin, P

“…Although usually thought of as external environmental stressors, a significant heritable component has been reported for measures of stressful life events…”
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Family history of depression is associated with younger age of onset in patients with recurrent depression by Tozzi, F, Prokopenko, I, Perry, J D, Kennedy, J L, McCarthy, A D, Holsboer, F, Berrettini, W, Middleton, L T, Chilcoat, H D, Muglia, P

“…Genetic epidemiology data suggest that younger age of onset is associated with family history (FH) of depression. The present study tested whether the presence…”
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Association between the BDNF gene and schizophrenia by Muglia, P, Vicente, A M, Verga, M, King, N, Macciardi, F, Kennedy, J L

“…Molecular Psychiatry (2002) 8, 146-147. doi:10.1038/sj.mp.4001221…”
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A follow-up case-control association study of tractable (druggable) genes in recurrent major depression by Schosser, A., Gaysina, D., Cohen-Woods, S., Domenici, E., Perry, J., Tozzi, F., Korszun, A., Gunasinghe, C., Gray, J., Jones, L., Binder, E.B., Holsboer, F., Craddock, N., Owen, M.J., Craig, I.W., Farmer, A.E., Muglia, P., McGuffin, P.

“…The High‐Throughput Disease‐specific target Identification Program (HiTDIP) aimed to study case–control association samples for 18 common diseases. Here we…”
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Childhood Inattention and Dysphoria and Adult Obesity Associated with the Dopamine D4 receptor Gene in Overeating Women with Seasonal Affective Disorder by LEVITAN, R. D, MASELLIS, M, LAM, R. W, MUGLIA, P, BASILE, V. S, JAIN, U, KAPLAN, A. S, THARMALINGAM, S, KENNEDY, S. H, KENNEDY, J. L

“…There is significant evidence that altered dopamine activity plays a role in seasonal affective disorder (SAD). The current study examined three separate…”
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Dopamine D4 receptor and tyrosine hydroxylase genes in bipolar disorder: Evidence for a role of DRD4 by MUGLIA, P, PETRONIS, A, MUNDO, E, LANDER, S, CATE, T, KENNEDY, J. L

“…The involvement of the mesocorticolimbic dopamine system in behaviors that are compromised in patients with mood disorder has led to the investigation of…”
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P.1.034 Copy number variants in CYP450 psychotropic drug metabolising enzymes in a large study of recurrent depressive disorder by Rucker, J.J.H, Aitchison, K, Cohen-Woods, S, Lewis, C.M, Uher, R, Craddock, M, Owen, M, Muglia, P, Breen, G, McGuffin, P

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174 – Genomic findings in schizophrenia, animal models and intermediate phenotypes by Rujescu, D, Giegling, I, Hartmann, A.M, Genius, J, Mulert, C, Hegerl, U, Ruppert, A, Grunze, H, Francks, C, Muglia, P, Möller, H.J

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P.1.15 Association of dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS) by Gaysina, D, Cohen, S, Chow, P.C, Martucci, L, Tozzi, F, Perry, J, Muglia, P, Craig, I.W, McGuffin, P, Farmer, A

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Serotonin transporter gene and adverse life events in adult ADHD by Mandelli, L, Muller, D.J, Serretti, A, DeYoung, C.G, De luca, V, Sicard, T, Tharmalingam, S, Gallinat, J, Muglia, P, De Ronchi, D, Jain, U, Kennedy, J.L

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The Brain-Derived Neurotrophic Factor Gene Confers Susceptibility to Bipolar Disorder: Evidence from a Family-Based Association Study by Neves-Pereira, Maria, Mundo, Emanuela, Muglia, Pierandrea, King, Nicole, Macciardi, Fabio, Kennedy, James L.

“…Bipolar disorder (BP) is a severe psychiatric disease, with a strong genetic component, that affects 1% of the population worldwide and is characterized by…”
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Decision-making deficits and overeating: a risk model for obesity by Davis, C, Levitan, R.D, Muglia, P, Bewell, C, Kennedy, J.L

“…Objective: To demonstrate that human overeating is not just a passive response to salient environmental triggers and powerful physiological drives; it is also…”
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NS11821, a partial subtype-selective GABAA agonist, elicits selective effects on the central nervous system in randomized controlled trial with healthy subjects by Zuiker, Rob GJA, Chen, Xia, Østerberg, Ole, Mirza, Naheed R, Muglia, Pierandrea, de Kam, Marieke, Klaassen, Erica S, van Gerven, Joop MA

“…NS11821 is a partial GABAA agonist with relatively dominant α2,3 and α5 subtype efficacy but negligible α1 agonism. This first-in-human study was performed in…”
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Factor structure and external validity of the PANSS revisited by Van den Oord, Edwin J.C.G., Rujescu, Dan, Robles, Jaime R., Giegling, Ina, Birrell, Claire, Bukszár, József, Murrelle, Lenn, Möller, Hans-Jürgen, Middleton, Lefkos, Muglia, Pierandrea

“…Considerable controversy exists concerning the positive and negative syndrome scale (PANSS), one of the most widely used instruments in schizophrenia research…”
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