Search Results - "Mugler, Andrew"

Limits to the precision of gradient sensing with spatial communication and temporal integration by Mugler, Andrew, Levchenko, Andre, Nemenman, Ilya

“…Gradient sensing requires at least two measurements at different points in space. These measurements must then be communicated to a common location to be…”
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Diffusion vs. direct transport in the precision of morphogen readout by Fancher, Sean, Mugler, Andrew

“…Morphogen profiles allow cells to determine their position within a developing organism, but not all morphogen profiles form by the same mechanism. Here, we…”
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Optimal Prediction by Cellular Signaling Networks by Becker, Nils B, Mugler, Andrew, Ten Wolde, Pieter Rein

“…Living cells can enhance their fitness by anticipating environmental change. We study how accurately linear signaling networks in cells can predict future…”
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Spatial partitioning improves the reliability of biochemical signaling by Mugler, Andrew, Tostevin, Filipe, ten Wolde, Pieter Rein

“…Spatial heterogeneity is a hallmark of living systems, even at the molecular scale in individual cells. A key example is the partitioning of membrane-bound…”
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Cell–cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis by Ellison, David, Mugler, Andrew, Brennan, Matthew D., Lee, Sung Hoon, Huebner, Robert J., Shamir, Eliah R., Woo, Laura A., Kim, Joseph, Amar, Patrick, Nemenman, Ilya, Ewald, Andrew J., Levchenko, Andre

“…Collective cell responses to exogenous cues depend on cell–cell interactions. In principle, these can result in enhanced sensitivity to weak and noisy stimuli…”
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Highly Polyvalent DNA Motors Generate 100+ pN of Force via Autochemophoresis by Blanchard, Aaron T, Bazrafshan, Alisina S, Yi, Jacob, Eisman, Julia T, Yehl, Kevin M, Bian, Teng, Mugler, Andrew, Salaita, Khalid

“…Motor proteins such as myosin, kinesin, and dynein are essential to eukaryotic life and power countless processes including muscle contraction, wound closure,…”
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Temporal precision of regulated gene expression by Gupta, Shivam, Varennes, Julien, Korswagen, Hendrik C, Mugler, Andrew

“…Important cellular processes such as migration, differentiation, and development often rely on precise timing. Yet, the molecular machinery that regulates…”
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Dynamic Sampling and Information Encoding in Biochemical Networks by Potter, Garrett D., Byrd, Tommy A., Mugler, Andrew, Sun, Bo

“…Cells use biochemical networks to translate environmental information into intracellular responses. These responses can be highly dynamic, but how the…”
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Physical constraints on accuracy and persistence during breast cancer cell chemotaxis by Varennes, Julien, Moon, Hye-Ran, Saha, Soutick, Mugler, Andrew, Han, Bumsoo

“…Directed cell motion in response to an external chemical gradient occurs in many biological phenomena such as wound healing, angiogenesis, and cancer…”
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Communication shapes sensory response in multicellular networks by Potter, Garrett D., Byrd, Tommy A., Mugler, Andrew, Sun, Bo

“…Collective sensing by interacting cells is observed in a variety of biological systems, and yet, a quantitative understanding of how sensory information is…”
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Growth of bacteria in 3-d colonies by Shao, Xinxian, Mugler, Andrew, Kim, Justin, Jeong, Ha Jun, Levin, Bruce R, Nemenman, Ilya

“…The dynamics of growth of bacterial populations has been extensively studied for planktonic cells in well-agitated liquid culture, in which all cells have…”
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Optimal antimicrobial response to a changing microbial background at a mucus interface by Bossa, Guilherme Volpe, Bel, Shai, Mugler, Andrew, Erez, Amir

“…Complex lifeforms host microbiota, microbes that live synergistically with their host. Accordingly, hosts have mechanisms to defend against and tolerate the…”
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Signal Percolation within a Bacterial Community by Larkin, Joseph W, Zhai, Xiaoling, Kikuchi, Kaito, Redford, Samuel E, Prindle, Arthur, Liu, Jintao, Greenfield, Sacha, Walczak, Aleksandra M, Garcia-Ojalvo, Jordi, Mugler, Andrew, Süel, Gürol M

“…Signal transmission among cells enables long-range coordination in biological systems. However, the scarcity of quantitative measurements hinders…”
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Cooperative Clustering Digitizes Biochemical Signaling and Enhances its Fidelity by Roob, Edward, Trendel, Nicola, Rein ten Wolde, Pieter, Mugler, Andrew

“…Many membrane-bound molecules in cells form small clusters. It has been hypothesized that these clusters convert an analog extracellular signal into a digital…”
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Importance of Crowding in Signaling, Genetic, and Metabolic Networks by ten Wolde, Pieter Rein, Mugler, Andrew

“…It is now well established that the cell is a highly crowded environment. Yet, the effects of crowding on the dynamics of signaling pathways, gene regulation…”
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Membrane Clustering and the Role of Rebinding in Biochemical Signaling by Mugler, Andrew, Bailey, Aimee Gotway, Takahashi, Koichi, Rein ten Wolde, Pieter

“…In many cellular signaling pathways, key components form clusters at the cell membrane. Although much work has focused on the mechanisms behind such cluster…”
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Precise temporal control of neuroblast migration through combined regulation and feedback of a Wnt receptor by Schild, Erik S, Gupta, Shivam, Dubois, Clément, Fernandes Póvoa, Euclides E, Félix, Marie-Anne, Mugler, Andrew, Korswagen, Hendrik C

“…Many developmental processes depend on precise temporal control of gene expression. We have previously established a theoretical framework for regulatory…”
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Statistics of correlated percolation in a bacterial community by Zhai, Xiaoling, Larkin, Joseph W, Kikuchi, Kaito, Redford, Samuel E, Roy, Ushasi, Süel, Gürol M, Mugler, Andrew

“…Signal propagation over long distances is a ubiquitous feature of multicellular communities, but cell-to-cell variability can cause propagation to be highly…”
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Noise Expands the Response Range of the Bacillus subtilis Competence Circuit by Mugler, Andrew, Kittisopikul, Mark, Hayden, Luke, Liu, Jintao, Wiggins, Chris H, Süel, Gürol M, Walczak, Aleksandra M

“…Gene regulatory circuits must contend with intrinsic noise that arises due to finite numbers of proteins. While some circuits act to reduce this noise, others…”
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Deduction of signaling mechanisms from cellular responses to multiple cues by Saha, Soutick, Moon, Hye-ran, Han, Bumsoo, Mugler, Andrew

“…Cell signaling networks are complex and often incompletely characterized, making it difficult to obtain a comprehensive picture of the mechanisms they encode…”
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