Brain natriuretic peptide in acute heart failure and its association with glomerular filtration rate: A systematic review and meta-analysis

Acute heart failure (AHF) is one of the most common cardiovascular diseases. Early diagnosis and prognosis are essential, as they can eventually lead to a fatal condition. Recently, brain natriuretic peptide (BNP) has been recognized as one of the most popular biomarkers for AHF. Changes in glomerul...

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Bibliographic Details
Published in:	Medicine (Baltimore) Vol. 103; no. 8; p. e36933
Main Authors:	Mughal, Hamdah Bashir, Majeed, Ayesha Isani, Aftab, Maria, Ubaid, Muhammad Furqan, Zahra, Sabahat, Abbasi, Muhammad Sajid Rafiq, Qadir, Mamoon, Ahmad, Mumtaz, Akbar, Amna, Tasneem, Sabahat, Jadoon, Sarosh Khan, Tariq, Maham, Hussain, Saddam, Khandker, Shahad Saif, Alvi, Sarosh
Format:	Journal Article
Language:	English
Published:	United States Lippincott Williams & Wilkins 23-02-2024
Subjects:	Acute Disease Biomarkers Glomerular Filtration Rate Heart Failure - complications Heart Failure - diagnosis Humans Natriuretic Peptide, Brain Peptide Fragments Prognosis Systematic Review and Meta-Analysis
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Summary:	Acute heart failure (AHF) is one of the most common cardiovascular diseases. Early diagnosis and prognosis are essential, as they can eventually lead to a fatal condition. Recently, brain natriuretic peptide (BNP) has been recognized as one of the most popular biomarkers for AHF. Changes in glomerular filtration rate (GFR) are often observed in AHF. We searched PubMed, Google Scholar, and ScienceDirect between March and June 2023. Original case control studies written in English that assessed levels oh BNP in AHF were included. Systematic reviews, letters to editor, correspondence, comprehensive reviews, and duplicated studies were excluded. Funnel plots were constructed to assess publication bias. A total of 9 studies were selected and we obtained the mean difference (MD) of BNP level to be 2.57 (95% CI: 1.35, 3.78), and GFR to be -15.52, (95% CI: -23.35, -7.70) in AHF patients. Sensitivity analyses supported the robustness of the outcome. Results indicated that BNP was a promising prognostic biomarker of AHF, whereas GFR was found to be negatively correlated with AHF.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	0025-7974 1536-5964 1536-5964
DOI:	10.1097/MD.0000000000036933