Search Results - "Mugford, Paul F."

Enzyme engineering: A synthetic biology approach for more effective library generation and automated high-throughput screening by Quaglia, Daniela, Ebert, Maximilian C C J C, Mugford, Paul F, Pelletier, Joelle N

“…The Golden Gate strategy entails the use of type IIS restriction enzymes, which cut outside of their recognition sequence. It enables unrestricted design of…”
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Enantiocomplementary Enzymes: Classification, Molecular Basis for Their Enantiopreference, and Prospects for Mirror-Image Biotransformations by Mugford, Paul F, Wagner, Ulrike G, Jiang, Yun, Faber, Kurt, Kazlauskas, Romas J

“…One often-cited weakness of biocatalysis is the lack of mirror-image enzymes for the formation of either enantiomer of a product in asymmetric synthesis…”
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C-NMR Regioisomeric Analysis of EPA and DHA in Fish Oil Derived Triacylglycerol Concentrates by Suárez, Erick Reyes, Mugford, Paul F, Rolle, Alfred J, Burton, Ian W, Walter, John A, Kralovec, Jaroslav A

“…The regio-isomeric distribution of the omega-3 polyunsaturated fatty acids (PUFA) cis-5,8,11,14,17-eicosapentaenoic acid (EPA) and…”
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13C-NMR Regioisomeric Analysis of EPA and DHA in Fish Oil Derived Triacylglycerol Concentrates by Suárez, Erick Reyes, Mugford, Paul F., Rolle, Alfred J., Burton, Ian W., Walter, John A., Kralovec, Jaroslav A.

“…The regio-isomeric distribution of the omega-3 polyunsaturated fatty acids (PUFA) cis -5,8,11,14,17-eicosapentaenoic acid (EPA) and cis…”
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Unexpected Subtilisin-Catalyzed Hydrolysis of a Sulfinamide Bond in Preference to a Carboxamide Bond in N-Acyl Sulfinamides by Mugford, Paul F, Magloire, Vladimir P, Kazlauskas, Romas J

“…Subtilisin Carlsberg-catalyzed hydrolysis of N-chloroacetyl p-toluenesulfinamide favored cleavage of the sulfinamide (S(O)−N) bond with a minor amount (∼25%)…”
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Enantiocomplementary Enzymatic Resolution of the Chiral Auxiliary: cis,cis-6-(2,2-Dimethylpropanamido)spiro[4.4]nonan-1-ol and the Molecular Basis for the High Enantioselectivity of Subtilisin Carlsberg by Mugford, Paul F, Lait, Susan M, Keay, Brian A, Kazlauskas, Romas J

“…cis,cis-(±)-6-(2,2-Dimethylpropanamido)spiro[4.4]nonan-1-ol, 1, a chiral auxiliary for Diels-Alder additions, was resolved by enzyme-catalyzed hydrolysis of…”
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sup 13^C-NMR Regioisomeric Analysis of EPA and DHA in Fish Oil Derived Triacylglycerol Concentrates by Suárez, Erick Reyes, Mugford, Paul F, Rolle, Alfred J, Burton, Ian W, Walter, John A, Kralovec, Jaroslav A

“…The regio-isomeric distribution of the omega-3 polyunsaturated fatty acids (PUFA) cis-5,8,11,14,17-eicosapentaenoic acid (EPA) and…”
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13 C‐NMR Regioisomeric Analysis of EPA and DHA in Fish Oil Derived Triacylglycerol Concentrates by Suárez, Erick Reyes, Mugford, Paul F., Rolle, Alfred J., Burton, Ian W., Walter, John A., Kralovec, Jaroslav A.

“…Abstract The regio‐isomeric distribution of the omega‐3 polyunsaturated fatty acids (PUFA) cis ‐5,8,11,14,17‐eicosapentaenoic acid (EPA) and cis…”
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Enantiokomplementäre Enzyme: Klassifizierung, molekulare Grundlage der Enantiopräferenz und Prognosen für spiegelbildliche Biotransformationen by Mugford, Paul F., Wagner, Ulrike G., Jiang, Yun, Faber, Kurt, Kazlauskas, Romas J.

“…Eine häufig zitierte Schwäche der Biokatalyse ist das Fehlen spiegelbildlicher Enzyme, um in asymmetrischen Synthesen jedes der beiden Enantiomere herstellen…”
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Expanding hydrolase catalyzed reactions to new substrates and reactions: Subtilisin catalyzed hydrolysis of sulfinamides and sterically hindered substrates by Mugford, Paul F

“…Enzymes are increasingly applied to organic synthesis because of their high enantioselectivity, chemoselectivity, and environmental friendliness. Hydrolytic…”
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Enantiokomplementäre Enzyme: Klassifizierung, molekulare Grundlage der Enantiopräferenz und Prognosen für spiegelbildliche Biotransformationen by Mugford, Paul F., Wagner, Ulrike G., Jiang, Yun, Faber, Kurt, Kazlauskas, Romas J.

“…Abstract Eine häufig zitierte Schwäche der Biokatalyse ist das Fehlen spiegelbildlicher Enzyme, um in asymmetrischen Synthesen jedes der beiden Enantiomere…”
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