Search Results - "Mugale, Madhav N."
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Inhaled Adjunct Therapy with Second-Line Drug Candidates for Dose Reduction in Chemotherapeutic Regimens for Multi-drug-Resistant Tuberculosis
Published in AAPS PharmSciTech (08-06-2023)“…Chemotherapy of multi-drug-resistant tuberculosis (TB) requires prolonged administration of multiple drugs. We investigated whether pulmonary delivery of…”
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Polycationic phosphorous dendrimer potentiates multiple antibiotics against drug-resistant mycobacterial pathogens
Published in Biomedicine & pharmacotherapy (01-04-2024)“…Mycobacterium tuberculosis (Mtb), causative agent of tuberculosis (TB) and non-tubercular mycobacterial (NTM) pathogens such as Mycobacterium abscessus are one…”
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CLUH functions as a negative regulator of inflammation in human macrophages and determines ulcerative colitis pathogenesis
Published in JCI insight (08-06-2023)“…Altered mitochondrial function without a well-defined cause has been documented in patients with ulcerative colitis (UC). In our efforts to understand UC…”
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Naringin and chloroquine combination mitigates chloroquine-resistant parasite-induced malaria pathogenesis by attenuating the inflammatory response
Published in Phytomedicine (Stuttgart) (01-10-2024)“…•Naringin (NGN), whether used alone or in combination with chloroquine (CQ), exhibited a potent anti-plasmodial effect against the CQ-resistant P. falciparum…”
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Accelerative Wound-Healing Effect of Aqueous Anthocephalus Cadamba Leaf Extract in a Diabetic Rat Model
Published in International journal of lower extremity wounds (01-06-2023)“…Impaired wound healing is a major concern in diabetic patients due to unregulated chronic hyperglycemia which further may lead to ulcer, gangrene, and its…”
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Hesperidin‐rich ethanol extract from waste peels of Citrus limetta mitigates rheumatoid arthritis and related complications
Published in Phytotherapy research (01-06-2021)“…The aim of this study is to explore the possible pharmacological effects of fruit waste that may have a key role in converting the fruit waste into…”
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Pharmacological and Toxicological Study of Coumarinolignoids from Cleome viscosa in Small Animals for the Management of Rheumatoid Arthritis
Published in Planta medica (01-01-2023)“…This study aims to explore the possible pharmacological potential of Linn (Cleomaceae), an annual weed, into therapeutic value-added products. In the present…”
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Ratiometric codelivery of Paclitaxel and Baicalein loaded nanoemulsion for enhancement of breast cancer treatment
Published in International journal of pharmaceutics (25-08-2023)“…[Display omitted] •Codelivery of Paclitaxel (PTX) and Baicalein (BCLN) exhibited a good synergistic effect.•PTX-BCLN loaded nanoemulsion showed improved in…”
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Correction: Preparation and Evaluation of Low-Dose Calcitriol Dry Powder Inhalation as Host-Directed Adjunct Therapy for Tuberculosis
Published in Pharmaceutical research (01-11-2022)Get full text
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Synchronized Codelivery of Combination Chemotherapies Intratumorally Using a Lipidic Lyotropic Liquid Crystal System
Published in ACS applied materials & interfaces (23-05-2024)“…In this work, an injectable in situ depot-forming lipidic lyotropic liquid crystal (L3C) system is developed to codeliver a precisely synchronized combination…”
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Preparation and Evaluation of Low-Dose Calcitriol Dry Powder Inhalation as Host-Directed Adjunct Therapy for Tuberculosis
Published in Pharmaceutical research (01-10-2022)“…Background It is unclear whether Vitamin D is efficacious as a host-directed therapy (HDT) for patients of tuberculosis (TB). We investigated pulmonary…”
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Self-Assembling Nano-Globular Peptide from Human Lactoferrin Acts as a Systemic Enhancer of Bone Regeneration: A Novel Peptide for Orthopedic Application
Published in ACS applied materials & interfaces (21-04-2021)“…A technology for systemic and repeated administration of osteogenic factors for orthopedic use is an unmet medical need. Lactoferrin (∼80 kDa), present in…”
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Macrophage-targeted versus free calcitriol as host-directed adjunct therapy against Mycobacterium tuberculosis infection in mice is bacteriostatic and mitigates tissue pathology
Published in Tuberculosis (Edinburgh, Scotland) (01-09-2024)“…Host-directed therapy (HDT) with vitamin D in tuberculosis (TB) is beneficial only if the subject is deficient in vitamin D. We investigated pulmonary delivery…”
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Liquiritigenin, isoliquiritigenin rich extract of glycyrrhiza glabra roots attenuates inflammation in macrophages and collagen-induced arthritis in rats
Published in Inflammopharmacology (01-04-2023)“…Liquiritigenin (LTG) and its bioprecursor isoliquiritigenin(ISL), the main bioactives from roots of Glycyrrhiza genus are progressively documented as a…”
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Enhanced apoptosis and mitochondrial cell death by paclitaxel-loaded TPP-TPGS1000-functionalized nanoemulsion
Published in Nanomedicine (London, England) (01-02-2023)Get full text
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Pancreastatin inhibitor PSTi8 protects the obesity associated skeletal muscle insulin resistance in diet induced streptozotocin-treated diabetic mice
Published in European journal of pharmacology (15-08-2020)“…Pancreastatin (PST), a chromogranin A (CHGA) derived peptide connects obesity with insulin resistance by inducing inflammation. Previously, we have evaluated…”
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Transient, inhaled gene therapy with gamma interferon mitigates pathology induced by host response in a mouse model of tuberculosis
Published in Tuberculosis (Edinburgh, Scotland) (01-05-2022)“…Transient transfection of the respiratory mucosa of mice infected with Mycobacterium tuberculosis (Mtb) with gamma interferon (IFN-γ) promises benefits in…”
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18
A retrospective evaluation of haematological values in clinical cases of water buffaloes
Published in Veterinary World (01-02-2013)“…Aim: To evaluate the important haematological values of the retrospective clinical cases of buffaloes presented to the Teaching Veterinary Hospital of the…”
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A review on polymers in ocular drug delivery systems
Published in MedComm - Biomaterials and applications (01-06-2024)“…Amid the escalating prevalence of eye diseases and the intricate nature of the eye as a crucial target organ for drug delivery, researchers face significant…”
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Enhanced apoptosis and mitochondrial cell death by paclitaxel-loaded TPP-TPGS 1000 -functionalized nanoemulsion
Published in Nanomedicine (London, England) (01-02-2023)“…The present research was designed to develop a nanoemulsion (NE) of triphenylphosphine-D-α-tocopheryl-polyethylene glycol succinate (TPP-TPGS ) and paclitaxel…”
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