Exercise capacity after COVID-related multisystem inflammatory syndrome in children-A cross-sectional study
After recovery from COVID-19 associated multisystem inflammatory syndrome in children (MISC), exercise restrictions were advised for 6 months. Studies done to assess exercise capacity at 3–6 months post recovery from MISC, prior to withdrawal of exercise restrictions, yielded varying information. Wh...
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| Published in: | Progress in pediatric cardiology Vol. 74; p. 101733 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier B.V
01-09-2024
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | After recovery from COVID-19 associated multisystem inflammatory syndrome in children (MISC), exercise restrictions were advised for 6 months. Studies done to assess exercise capacity at 3–6 months post recovery from MISC, prior to withdrawal of exercise restrictions, yielded varying information. Whether their exercise capacity was on par with their peers at/beyond 1-year post-recovery needed to be assessed.
Primary: To compare the exercise capacity between children with a history of MISC and unaffected children
Secondary: To compare the exercise capacity between a) children with a history of MISC and children with a history of COVID but not MISC b) children with a history of COVID but not MISC and unaffected children.
Children (aged ≥8 years) who had recovered from MISC >1-year ago (n = 21) were compared with unaffected children (n = 42) and children who had COVID but not MISC (n = 21) respectively using cardiopulmonary exercise testing (CPET). Comparisons were made between 1. Post-MISC vs unaffected 2. Post-MISC vs post-COVID 3. Post-COVID vs unaffected.
Compared with unaffected children, post-MISC and post-COVID groups had similar peak oxygen uptake (VO2 max) but significantly lesser exercise duration. Children who were very sick during their hospitalization for MISC had an exercise capacity comparable to others in the post-MISC group. Overweight/obese children in post-MISC group had a significantly lesser exercise capacity. But, the numbers of overweight/obese children and very sick children were not adequate to run a separate sub-group analysis.
At/beyond 1 year post-recovery from MISC, exercise capacity was comparable to healthy children and children who had COVID but not MISC, but exercise duration was significantly less. Overweight/obese children need to be followed up longer with emphasis on regular exercises. Children who were very sick during MISC hospitalization had recovered their exercise capacity.
•Prospective comparison of exercise capacity of children with a history of MISC with age & gender matched unaffected children.•All were at least 1-year post-recovery from MISC & off exercise restrictions at least for 6 months before enrollment.•Comparison with a group of children who had suffered COVID but not MISC to differentiate MISC effects Vs COVID sequelae.•Obese/overweight children in post-MISC group had exercise limitation but numbers were insufficient for sub-group analysis.•Children who were very sick during their hospitalization for MISC had comparable exercise capacity to the rest in the group. |
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| ISSN: | 1058-9813 |
| DOI: | 10.1016/j.ppedcard.2024.101733 |