Search Results - "Muffley, Lara A."

An Atlas of Variant Effects to understand the genome at nucleotide resolution by Fowler, Douglas M, Adams, David J, Gloyn, Anna L, Hahn, William C, Marks, Debora S, Muffley, Lara A, Neal, James T, Roth, Frederick P, Rubin, Alan F, Starita, Lea M, Hurles, Matthew E

“…Sequencing has revealed hundreds of millions of human genetic variants, and continued efforts will only add to this variant avalanche. Insufficient information…”
Get full text

Minimum information and guidelines for reporting a multiplexed assay of variant effect by Claussnitzer, Melina, Parikh, Victoria N, Wagner, Alex H, Arbesfeld, Jeremy A, Bult, Carol J, Firth, Helen V, Muffley, Lara A, Nguyen Ba, Alex N, Riehle, Kevin, Roth, Frederick P, Tabet, Daniel, Bolognesi, Benedetta, Glazer, Andrew M, Rubin, Alan F

“…Multiplexed assays of variant effect (MAVEs) have emerged as a powerful approach for interrogating thousands of genetic variants in a single experiment. The…”
Get full text

Race Does Not Predict Melanocyte Heterogeneous Responses to Dermal Fibroblast-Derived Mediators by Sirimahachaiyakul, Pornthep, Sood, Ravi F, Muffley, Lara A, Seaton, Max, Lin, Cheng-Ta, Qiao, Liang, Armaly, Jeffrey S, Hocking, Anne M, Gibran, Nicole S

“…Abnormal pigmentation following cutaneous injury causes significant patient distress and represents a barrier to recovery. Wound depth and patient…”
Get full text

Morphological evidence for the role of suprabasal keratinocytes in wound reepithelialization by Usui, Marcia L., Underwood, Robert A., Mansbridge, Jonathan N., Muffley, Lara A., Carter, William G., Olerud, John E.

“…The process by which wounds reepithelialize remains controversial. Two models have been proposed to describe reepithelialization: the “sliding” model and the…”
Get full text

Nerve growth factor accelerates wound healing in diabetic mice by Muangman, Pornprom, Muffley, Lara A., Anthony, Joanne P., Spenny, Michelle L., Underwood, Robert A., Olerud, John E., Gibran, Nicole S.

“…Patients with diabetic neuropathy have reduced numbers of cutaneous nerves, which may contribute to an increased incidence of nonhealing wounds. Nerve growth…”
Get full text

Mesenchymal stem cells induce dermal fibroblast responses to injury by Smith, Andria N., Willis, Elise, Chan, Vincent T., Muffley, Lara A., Isik, F. Frank, Gibran, Nicole S., Hocking, Anne M.

“…Although bone marrow-derived mesenchymal stem cells have been shown to promote repair when applied to cutaneous wounds, the mechanism for this response remains…”
Get full text

Race and Melanocortin 1 Receptor Polymorphism R163Q Are Associated with Post-Burn Hypertrophic Scarring: A Prospective Cohort Study by Sood, Ravi F., Hocking, Anne M., Muffley, Lara A., Ga, Maricar, Honari, Shari, Reiner, Alexander P., Rowhani-Rahbar, Ali, Gibran, Nicole S.

“…The genetic determinants of post-burn hypertrophic scarring (HTS) are unknown, and melanocortin 1 receptor (MC1R) loss-of-function leads to fibrogenesis in…”
Get full text

Topical application of laminin-332 to diabetic mouse wounds by Sullivan, Stephen R, Underwood, Robert A, Sigle, Randall O, Fukano, Yuko, Muffley, Lara A, Usui, Marcia L, Gibran, Nicole S, Antezana, Marcos A, Carter, William G, Olerud, John E

“…Summary Background Keratinocyte migration is essential for wound healing and diabetic wound keratinocytes migrate poorly. Keratinocyte migration and anchorage…”
Get full text

Genetic risk factors for hypertrophic scar development by Thompson, Callie M, Hocking, Anne M, Honari, Shari, Muffley, Lara A, Ga, Maricar, Gibran, Nicole S

“…Hypertrophic scars (HTSs) occur in 30 to 72% patients after thermal injury. Risk factors include skin color, female sex, young age, burn site, and burn…”
Get full text

Unsaturated fatty acids induce mesenchymal stem cells to increase secretion of angiogenic mediators by Smith, Andria N., Muffley, Lara A., Bell, Austin N., Numhom, Surawej, Hocking, Anne M.

“…Mesenchymal stem cells (MSC) represent emerging cell‐based therapies for diabetes and associated complications. Ongoing clinical trials are using exogenous MSC…”
Get full text

The Effects of Early Neuropathic Pain Control With Gabapentin on Long-Term Chronic Pain and Itch in Burn Patients by Kneib, Cameron J, Sibbett, Stephen H, Carrougher, Gretchen J, Muffley, Lara A, Gibran, Nicole S, Mandell, Samuel P

“…ABSTRACT Gabapentin has analgesic efficacy for neuropathic pain and is increasingly used in burn care. This study investigated the effect of a neuropathic pain…”
Get full text

Genome-wide Association Study of Postburn Scarring Identifies a Novel Protective Variant by Sood, Ravi F, Hocking, Anne M, Muffley, Lara A, Ga, Maricar, Honari, Shari, Reiner, Alexander P, Gibran, Nicole S

“…OBJECTIVE:To identify genetic variants associated with the severity of postburn hypertrophic scarring (HTS) using a genome-wide approach. BACKGROUND:Risk of…”
Get full text

Use of Best Practice Strategies to Improve Longitudinal Study Participation: Analysis of Telephone Contact Data From the Northwest Regional Burn Model System by Carrougher, Gretchen J, Muffley, Lara A, Baker, Claudia P, Gibran, Nicole S

“…Successful acquisition of survey data in any longitudinal study is key to reducing bias and determining reliable, generalizable findings. As part of a…”
Get full text

Targeted metabolic profiling of wounds in diabetic and nondiabetic mice by Sood, Ravi F., Gu, Haiwei, Djukovic, Danijel, Deng, Lingli, Ga, Maricar, Muffley, Lara A., Raftery, Daniel, Hocking, Anne M.

“…ABSTRACT While cellular metabolism is known to regulate a number of key biological processes such as cell growth and proliferation, its role in wound healing…”
Get full text

Dermal Fibroblasts from the Red Duroc Pig Have an Inherently Fibrogenic Phenotype: An In Vitro Model of Fibroproliferative Scarring by Sood, Ravi F., Muffley, Lara A., Seaton, Max E., Ga, Maricar, Sirimahachaiyakul, Pornthep, Hocking, Anne M., Gibran, Nicole S.

“…The pathophysiology of hypertrophic scarring is unknown in part because of the lack of a robust animal model. Although the red Duroc pig has emerged as a…”
Get full text

MC1R gene polymorphisms are associated with dysfunctional immune responses and wound infection after burn injury by Carter, Damien W., Sood, Ravi F., Seaton, Max E., Muffley, Lara A., Honari, Shari, Hocking, Ann M., Arbabi, Saman A., Gibran, Nicole S.

“…Systemic inflammatory response syndrome (SIRS) is associated with organ failure and infectious complications after major burn injury. Recent evidence has…”
Get full text

Substance P Enhances Wound Closure in Nitric Oxide Synthase Knockout Mice by Muangman, Pornprom, M.D, Tamura, Richard N., Ph.D, Muffley, Lara A., B.S, Isik, F. Frank, M.D, Scott, Jeffrey R., M.D, Xie, Chengyu, M.D, Kegel, Gary, M.D, Sullivan, Stephen R., M.D, Liang, Zhi, M.D, Gibran, Nicole S., M.D

“…Introduction The neuropeptide, substance P (SP), up-regulates nitric oxide production (NO). The purpose of this study was to determine whether SP enhances…”
Get full text

Spatial and Temporal Localization of the Melanocortin 1 Receptor and Its Ligand α–Melanocyte-Stimulating Hormone during Cutaneous Wound Repair by Muffley, Lara A., Zhu, Kathy Q., Engrav, Loren H., Gibran, Nicole S., Hocking, Anne M.

“…Growing evidence indicates that the melanocortin 1 receptor (MC1R) and its ligand α–melanocyte-stimulating hormone (α-MSH) have other functions in the skin in…”
Get full text

Melanocortin-1 Receptor Polymorphisms and the Risk of Complicated Sepsis After Trauma: A Candidate Gene Association Study by Seaton, Max E, Parent, Brodie A, Sood, Ravi F, Wurfel, Mark M, Muffley, Lara A, O’Keefe, Grant E, Gibran, Nicole S

“…OBJECTIVE:To determine if melanocortin-1 receptor (MC1R) single nucleotide polymorphisms (SNPs) are associated with complicated sepsis after trauma…”
Get full text

Differentiation state determines neural effects on microvascular endothelial cells by Muffley, Lara A., Pan, Shin-Chen, Smith, Andria N., Ga, Maricar, Hocking, Anne M., Gibran, Nicole S.

“…Growing evidence indicates that nerves and capillaries interact paracrinely in uninjured skin and cutaneous wounds. Although mature neurons are the predominant…”
Get full text