Search Results - "Muenzer, Jared"

Reactivation of multiple viruses in patients with sepsis by Walton, Andrew H, Muenzer, Jared T, Rasche, David, Boomer, Jonathan S, Sato, Bryan, Brownstein, Bernard H, Pachot, Alexandre, Brooks, Terrence L, Deych, Elena, Shannon, William D, Green, Jonathan M, Storch, Gregory A, Hotchkiss, Richard S

“…A current controversy is whether patients with sepsis progress to an immunosuppressed state. We hypothesized that reactivation of latent viruses occurred with…”
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Nitric oxide delivery during cardiopulmonary bypass reduces postoperative morbidity in children—a randomized trial by Checchia, Paul A., MD, FCCM, FACC, Bronicki, Ronald A., MD, Muenzer, Jared T., MD, Dixon, David, PhD, Raithel, Steve, BS, CCP, Gandhi, Sanjiv K., MD, Huddleston, Charles B., MD

“…Objective Cardiac surgery requiring cardiopulmonary bypass and cardioplegic arrest leads to myocardial ischemic and reperfusion injury. Gaseous nitric oxide…”
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Neutrophils are significant producers of IL-10 during sepsis by Kasten, Kevin R., Muenzer, Jared T., Caldwell, Charles C.

“…Sepsis is a syndrome involving systemic inflammation as well as an infectious focus. Accordingly, the host immune response to sepsis involves complex leukocyte…”
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Characterization and Modulation of the Immunosuppressive Phase of Sepsis by Muenzer, Jared T, Davis, Christopher G, Chang, Kathy, Schmidt, Robert E, Dunne, W. Michael, Coopersmith, Craig M, Hotchkiss, Richard S

“…Sepsis continues to cause significant morbidity and mortality in critically ill patients. Studies of patients and animal models have revealed that changes in…”
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IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis by Unsinger, Jacqueline, McGlynn, Margaret, Kasten, Kevin R, Hoekzema, Andrew S, Watanabe, Eizo, Muenzer, Jared T, McDonough, Jacquelyn S, Tschoep, Johannes, Ferguson, Thomas A, McDunn, Jonathan E, Morre, Michel, Hildeman, David A, Caldwell, Charles C, Hotchkiss, Richard S

“…Sepsis is a highly lethal disorder characterized by widespread apoptosis-induced depletion of immune cells and the development of a profound immunosuppressive…”
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IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis by Inoue, Shigeaki, Unsinger, Jacqueline, Davis, Christopher G, Muenzer, Jared T, Ferguson, Thomas A, Chang, Katherine, Osborne, Dale F, Clark, Andrew T, Coopersmith, Craig M, McDunn, Jonathan E, Hotchkiss, Richard S

“…IL-15 is a pluripotent antiapoptotic cytokine that signals to cells of both the innate and adaptive immune system and is regarded as a highly promising…”
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Outcomes of Arterial Vascular Extremity Trauma in Pediatric Patients by Kirkilas, Mary, Notrica, David M, Langlais, Crystal S, Muenzer, Jared T, Zoldos, Jozef, Graziano, Kathleen

“…Abstract Background Vascular trauma in children, although rare, carries significant risk for repair. Here we report outcomes from a single trauma center for…”
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Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis by Chang, Katherine C, Unsinger, Jacqueline, Davis, Christopher G, Schwulst, Steven J, Muenzer, Jared T, Strasser, Andreas, Hotchkiss, Richard S

“…Lymphocyte apoptosis plays a central role in the pathophysiology of sepsis. Lymphocyte apoptosis was examined in mice with defective death receptor pathways…”
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Detection of viruses in young children with fever without an apparent source by Colvin, Joshua M, Muenzer, Jared T, Jaffe, David M, Smason, Avraham, Deych, Elena, Shannon, William D, Arens, Max Q, Buller, Richard S, Lee, Wai-Ming, Weinstock, Erica J Sodergren, Weinstock, George M, Storch, Gregory A

“…Fever without an apparent source is common in young children. Currently in the United States, serious bacterial infection is unusual. Our objective was to…”
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Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study by Watanabe, Eizo, Muenzer, Jared T, Hawkins, William G, Davis, Christopher G, Dixon, David J, McDunn, Jonathan E, Brackett, Daniel J, Lerner, Megan R, Swanson, Paul E, Hotchkiss, Richard S

“…Autophagy is the regulated process cells use to recycle nonessential, redundant, or inefficient components and is an adaptive response during times of stress…”
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Outcomes of digital artery revascularization in pediatric trauma by Linnaus, Maria E, Langlais, Crystal S, Kirkilas, Mary, Muenzer, Jared T, Zoldos, Jozef, Graziano, Kathleen, Notrica, David M

“…Abstract Background Digit amputation is rare in pediatric trauma but can lead to functional morbidity. The true incidence of digital arterial injury is lacking…”
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L-plastin is essential for alveolar macrophage production and control of pulmonary pneumococcal infection by Deady, Lauren E, Todd, Elizabeth M, Davis, Chris G, Zhou, Julie Y, Topcagic, Nermina, Edelson, Brian T, Ferkol, Thomas W, Cooper, Megan A, Muenzer, Jared T, Morley, Sharon Celeste

“…We report that mice deficient for the hematopoietic-specific, actin-bundling protein L-plastin (LPL) succumb rapidly to intratracheal pneumococcal infection…”
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Increased susceptibility to Candida infection following cecal ligation and puncture by Davis, Christopher G., Chang, Kathy, Osborne, Dale, Walton, Andrew H., Dunne, W. Michael, Muenzer, Jared T.

“…► We developed a double injury model of CLP followed by Candida albicans. ► We characterized the changes in immune suppression following initial septic insult…”
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TLR3 agonist improves survival to secondary pneumonia in a double injury model by Davis, Christopher G., AA, Chang, Kathy, PhD, Osborne, Dale, BS, Walton, Andrew H., MS, Ghosh, Sarbani, MS, Dunne, William Michael, PhD, Hotchkiss, Richard S., MD, Muenzer, Jared T., MD

“…Abstract Background Toll-like receptors (TLR) can initiate various immune responses and are therefore activated under diverse infectious states. Previous…”
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Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis by Muenzer, Jared T, Davis, Christopher G, Dunne, Benjamin S, Unsinger, Jacqueline, Dunne, W Michael, Hotchkiss, Richard S

“…Sepsis continues to be the primary cause of death among patients in surgical intensive care units. In many cases, death does not result from the initial septic…”
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Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis by Schwulst, Steven J, Muenzer, Jared T, Peck-Palmer, Octavia M, Chang, Katherine C, Davis, Christopher G, McDonough, Jacquelyn S, Osborne, Dale F, Walton, Andrew H, Unsinger, Jacqueline, McDunn, Jonathan E, Hotchkiss, Richard S

“…To assess the degree of lymphocyte apoptosis and survival in mice treated with small interfering RNA (siRNA) targeted to Bim, a proapoptotic molecule from the…”
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Lymphocyte Phenotyping to Distinguish Septic from Nonseptic Critical Illness by Schwulst, Steven J., MD, Muenzer, Jared T., MD, Chang, Katherine C., PhD, Brahmbhatt, Tejal S., MD, Coopersmith, Craig M., MD, FACS, Hotchkiss, Richard S., MD

“…Background Clinical signs and symptoms of sepsis are nonspecific and often indistinguishable from those of nonseptic critical illness. This ambiguity…”
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The Role of TCR Engagement and Activation-Induced Cell Death in Sepsis-Induced T Cell Apoptosis by Unsinger, Jacqueline, Herndon, John M, Davis, Christopher G, Muenzer, Jared T, Hotchkiss, Richard S, Ferguson, Thomas A

“…Sepsis induces extensive apoptosis in T and B cells suggesting that the loss of immune effector cells could be one explanation for the profound…”
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Evaluation of the Precision of Emergency Department Diagnoses in Young Children With Fever by Colvin, Joshua M., Jaffe, David M., Muenzer, Jared T.

“…Objective. To characterize causes of fever in children presenting to a pediatric emergency department (ED). Methods. One-year retrospective review of ED…”
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Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis by McDunn, Jonathan E, Muenzer, Jared T, Rachdi, Latif, Chang, Katherine C, Davis, Chris G, Dunne, W. Michael, Piwnica-Worms, David, Bernal-Mizrachi, Ernesto, Hotchkiss, Richard S

“…Lymphocyte apoptosis is a hallmark of sepsis and contributes to disease mortality. In other acute injuries, such as myocardial and cerebral…”
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