Search Results - "Muellner, Frank W."

Development of a Scalable Process for DG-041, a Potent EP3 Receptor Antagonist, via Tandem Heck Reactions by Zegar, Siead, Tokar, Christopher, Enache, Livia A, Rajagopol, Venkat, Zeller, Wayne, O'Connell, Matthew, Singh, Jasbir, Muellner, Frank W, Zembower, David E

“…DG-041 is a small molecule antagonist of the EP3 receptor for prostaglandin E2 that is in clinical development for treatment of peripheral artery disease…”
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Development of a Scalable Synthetic Process for DG-051B, A First-in-Class Inhibitior of LTA4H by Enache, Livia A, Kennedy, Isaac, Sullins, David W, Chen, Wei, Ristic, Dragan, Stahl, Glenn L, Dzekhtser, Sergey, Erickson, Robert A, Yan, Changren, Muellner, Frank W, Krohn, Michael D, Winger, Jennifer, Sandanayaka, Vincent, Singh, Jasbir, Zembower, David E, Kiselyov, Alex S

“…DG-051B is a first-in-class small molecule inhibitor of leukotriene A4 hydrolase (LTA4H), currently in Phase II clinical development for the prevention of…”
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Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051 by Enache, Livia A., Zhang, Jun, Sullins, David W., Kennedy, Isaac, Onua, Emmanuel, Zembower, David E., Muellner, Frank W., Singh, Jasbir, Kiselyov, Alex S.

“…The identification and synthesis of two CYP mediated metabolites of DG-051 are reported. The same two major CYP mediated metabolites of DG-051 were produced in…”
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Total synthesis of 7,7-, 10,10-, and 13,13-difluoroarachidonic acids by Kwok, Pui Yan, Muellner, Frank W, Chen, Chien Kuang, Fried, Josef

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Pilot-Plant Preparation of an αvβ3 Integrin Antagonist. Part 3. Process Research and Development of a Diisopropylcarbodiimide and Catalytic 1-Hydroxybenzotriazole Peptide Coupling by Clark, Jerry D, Anderson, D. Keith, Banaszak, David V, Brown, Derek B, Czyzewski, Ann M, Edeny, Albert D, Forouzi, Puneh S, Gallagher, Donald J, Iskos, V. H, Kleine, H. Peter, Knable, Carl M, Lantz, Melissa K, Lapack, Mark A, Moore, Christine M. V, Muellner, Frank W, Murphy, James B, Orihuela, Carlos A, Pietz, Mark A, Rogers, Thomas E, Ruminski, Peter G, Santhanam, Harish K, Schilke, Tobin C, Shah, Ajit S, Sheikh, Ahmad Y, Weisenburger, Gerald A, Wise, Bruce E

“…Studies directed toward the process research, development, and scale-up preparation of the potential αvβ3 integrin antagonist 1 are described. A convergent…”
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Enzymatic conversions of 10,10-difluoroarachidonic acid with PGH synthase and soybean lipoxygenase by Kwok, Pui Yan, Muellner, Frank W, Fried, Josef

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Pilot-Plant Preparation of an α v β 3 Integrin Antagonist. Part 3. Process Research and Development of a Diisopropylcarbodiimide and Catalytic 1-Hydroxybenzotriazole Peptide Coupling by Clark, Jerry D., Anderson, D. Keith, Banaszak, David V., Brown, Derek B., Czyzewski, Ann M., Edeny, Albert D., Forouzi, Puneh S., Gallagher, Donald J., Iskos, V. H., Kleine, H. Peter, Knable, Carl M., Lantz, Melissa K., Lapack, Mark A., Moore, Christine M. V., Muellner, Frank W., Murphy, James B., Orihuela, Carlos A., Pietz, Mark A., Rogers, Thomas E., Ruminski, Peter G., Santhanam, Harish K., Schilke, Tobin C., Shah, Ajit S., Sheikh, Ahmad Y., Weisenburger, Gerald A., Wise, Bruce E.

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Development of a Scalable Process for DG-041, a Potent EP 3 Receptor Antagonist, via Tandem Heck Reactions by Zegar, Siead, Tokar, Christopher, Enache, Livia A., Rajagopol, Venkat, Zeller, Wayne, O'Connell, Matthew, Singh, Jasbir, Muellner, Frank W., Zembower, David E.

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A practical synthesis of an HIV protease inhibitor intermediate - diastereoselective epoxide formation from chiral α-aminoaldehydes by Ng, John S., Przybyla, Claire A., Liu, Chin, Yen, Joe C., Muellner, Frank W., Weyker, Cara L.

“…A practical and efficient synthesis of an HIV protease inhibitor intermediate has been developed based on the diastereoselective epoxide formation from a…”
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4,5-Dibenzyloxybenzyne as a synthon for diels-alder reactions. The synthesis of 6,7-dihydroxy-1,4-ethano-1,2,3,4-tetrahydroisoquinolines as rigid analogs of adrenergic agents. Assignment of proton and carbon-13 NMR parameters using homonuclear and heteronuclear two-dimensional chemical shift correlation NMR spectroscopy by Muellner, Frank W., Abdel-Sayed, Ashraf N., Bauer, Ludwig

“…The synthesis of several rigid analogs of catecholamine type of adrenergic agents is reported. Their synthesis began with a Diels‐Alder cycloaddition of…”
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The synthesis of 1,4-ethano-1,2,3,4-tetrahydroisoquinolines as rigid analogues of adrenergic agents by Muellner, Frank W., Bauer, Ludwig

“…The Diels‐Alder addition of benzyne and 4,5‐dimethoxybenzyne to 1‐(2‐trans‐phenylvinyl)‐2‐pyridone and 1‐benzyl‐3‐benzyloxy‐2‐pyridones provided members of the…”
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