Search Results - "Mueller, Tony"

Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease by Spoerl, Silvia, Mathew, Nimitha R., Bscheider, Michael, Schmitt-Graeff, Annette, Chen, Sophia, Mueller, Tony, Verbeek, Mareike, Fischer, Julius, Otten, Vera, Schmickl, Martina, Maas-Bauer, Kristina, Finke, Jürgen, Peschel, Christian, Duyster, Justus, Poeck, Hendrik, Zeiser, Robert, von Bubnoff, Nikolas

“…Graft-versus-host-disease (GVHD) is a severe complication of allogeneic hematopoietic cell transplantation (allo-HCT) characterized by the production of high…”
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Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure by Kreutmair, Stefanie, Erlacher, Miriam, Andrieux, Geoffroy, Istvanffy, Rouzanna, Mueller-Rudorf, Alina, Zwick, Melissa, Rückert, Tamina, Pantic, Milena, Poggio, Teresa, Shoumariyeh, Khalid, Mueller, Tony A, Kawaguchi, Hiroyuki, Follo, Marie, Klingeberg, Cathrin, Wlodarski, Marcin, Baumann, Irith, Pfeifer, Dietmar, Kulinski, Michal, Rudelius, Martina, Lemeer, Simone, Kuster, Bernhard, Dierks, Christine, Peschel, Christian, Cabezas-Wallscheid, Nina, Duque-Afonso, Jesus, Zeiser, Robert, Cleary, Michael L, Schindler, Detlev, Schmitt-Graeff, Annette, Boerries, Melanie, Niemeyer, Charlotte M, Oostendorp, Robert Aj, Duyster, Justus, Illert, Anna Lena

“…Inherited bone marrow failure syndromes (IBMFSs) are a heterogeneous group of disorders characterized by defective hematopoiesis, impaired stem cell function,…”
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NIPA (Nuclear Interaction Partner of ALK) Is Crucial for Effective NPM-ALK Mediated Lymphomagenesis by Kreutmair, Stefanie, Lippert, Lena Johanna, Klingeberg, Cathrin, Albers-Leischner, Corinna, Yacob, Salome, Shlyakhto, Valeria, Mueller, Tony, Mueller-Rudorf, Alina, Yu, Chuanjiang, Gorantla, Sivahari Prasad, Miething, Cornelius, Duyster, Justus, Illert, Anna Lena

“…The NPM-ALK fusion kinase is expressed in 60% of systemic anaplastic large-cell lymphomas (ALCL). A Nuclear Interaction Partner of ALK (NIPA) was identified as…”
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A newly identified 45‐kDa JAK2 variant with an altered kinase domain structure represents a novel mode of JAK2 kinase inhibitor resistance by Gorantla, Sivahari Prasad, Mueller, Tony Andreas, Albers‐Leischner, Corinna, Rudelius, Martina, Bubnoff, Nikolas, Duyster, Justus

“…Tyrosine‐protein kinase (janus kinase; JAK)–signal transducer and activator of transcription (STAT) signaling plays a pivotal role in the development of…”
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When policy entrepreneurs drift between levels: The creation of the International Renewable Energy Agency by Mueller, Tony

“…This article examines the crucial role of subnational actors in the diffusion of policy change at the international level, illustrated by the creation of the…”
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The (self-)empowerment of the European Central Bank during the sovereign debt crisis by Heldt, Eugénia C., Mueller, Tony

“…The European Central Bank (ECB) emerged from the sovereign debt crisis as one of the most powerful supranational institutions. Against this background, this…”
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In Europe we trust: selecting and empowering EU institutions in disruptive circumstances by Heldt, Eugenia C., Ríos Camacho, Elena, Mueller, Tony

“…Over the past decade, the European Union (EU) made significant strides in economic and fiscal policy integration without formal treaty-based changes. After the…”
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Bringing Independence and Accountability Together: Mission Impossible for the European Central Bank? by Heldt, Eugénia C., Müller, Tony

“…The European Central Bank's (ECB) role as a political actor during the euro crisis raised concerns about its independence and insufficient accountability…”
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The role of inflammasomes as central inflammatory hubs in Mycobacterium tuberculosis infection by Theobald, Sebastian J, Müller, Tony A, Lange, Dinah, Keck, Katharina, Rybniker, Jan

“…( ) infection represents a global health problem and is characterized by formation of granuloma with a necrotic center and a systemic inflammatory response…”
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The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL by Stachelscheid, Johanna, Jiang, Qu, Aszyk, Christoph, Warner, Kathrin, Bley, Nadine, Müller, Tony, Vydzhak, Olga, Symeonidis, Konstantinos, Crispatzu, Giuliano, Mayer, Petra, Blakemore, Stuart James, Goehring, Gudrun, Newrzela, Sebastian, Hippler, Stephanie, Robrecht, Sandra, Kreuzer, Karl-Anton, Pallasch, Christian, Krüger, Marcus, Lechner, Axel, Fischer, Kirsten, Stilgenbauer, Stephan, Beutner, Dirk, Hallek, Michael, Auguin, Daniel, Hüttelmaier, Stefan, Bloehdorn, Johannes, Vasyutina, Elena, Herling, Marco

“…•TCL1A directly engages CDC20 in the mitotic checkpoint complex, accelerating cell cycle transit and driving genome instability in B cells.•Downregulated CDC20…”
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Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia by Suske, Tobias, Sorger, Helena, Manhart, Gabriele, Ruge, Frank, Prutsch, Nicole, Zimmerman, Mark W, Eder, Thomas, Abdallah, Diaaeldin I, Maurer, Barbara, Wagner, Christina, Schönefeldt, Susann, Spirk, Katrin, Pichler, Alexander, Pemovska, Tea, Schweicker, Carmen, Pölöske, Daniel, Hubanic, Emina, Jungherz, Dennis, Müller, Tony Andreas, Aung, Myint Myat Khine, Orlova, Anna, Pham, Ha Thi Thanh, Zimmel, Kerstin, Krausgruber, Thomas, Bock, Christoph, Müller, Mathias, Dahlhoff, Maik, Boersma, Auke, Rülicke, Thomas, Fleck, Roman, de Araujo, Elvin Dominic, Gunning, Patrick Thomas, Aittokallio, Tero, Mustjoki, Satu, Sanda, Takaomi, Hartmann, Sylvia, Grebien, Florian, Hoermann, Gregor, Haferlach, Torsten, Staber, Philipp Bernhard, Neubauer, Heidi Anne, Look, Alfred Thomas, Herling, Marco, Moriggl, Richard

“…T cell acute lymphoblastic leukemia (T-ALL) is an aggressive immature T cell cancer. Mutations in IL7R have been analyzed genetically, but downstream effector…”
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Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia by Jiang, Qu, Stachelscheid, Johanna, Bloehdorn, Johannes, Pacholewska, Alicja, Aszyk, Christoph, Grotenhuijs, Francien, Müller, Tony, Onder, Ozlem, Wagle, Prerana, Herling, Carmen D., Kleppe, Maria, Wang, Zhefang, Coombes, Kevin R., Robrecht, Sandra, Dalvi, Priya S., Plosnita, Bianca, Mayer, Petra, Abruzzo, Lynne V., Altmüller, Janine, Gathof, Birgit, Persigehl, Thorsten, Fischer, Kirsten, Jebaraj, Billy, Rienhoff, Hugh Y., Ecker, Rupert, Zhao, Yue, Bruns, Christiane J., Stilgenbauer, Stephan, Elenitoba-Johnson, Kojo, Hallek, Michael, Schweiger, Michal R., Odenthal, Margarete, Vasyutina, Elena, Herling, Marco

“…•KDM1A activation marks high-risk CLL, and genetic KDM1A depletion impedes leukemic growth via cell-intrinsic and milieu-derived programs.•KDM1A loss alters H3…”
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NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia by Rudorf, Alina, Müller, Tony Andreas, Klingeberg, Cathrin, Kreutmair, Stefanie, Poggio, Teresa, Gorantla, Sivahari Prasad, Rückert, Tamina, Schmitt-Graeff, Annette, Gengenbacher, Anina, Paschka, Peter, Baldus, Claudia, Zeiser, Robert, Vassiliou, George S., Bradley, Allan, Duyster, Justus, Illert, Anna Lena

“…Activating mutations in FMS-like tyrosine kinase receptor-3 (FLT3) and Nucleophosmin-1 (NPM1) are most frequent alterations in acute myeloid leukemia (AML),…”
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Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia by Yu, Chuanjiang, Gorantla, Sivahari P, Müller-Rudorf, Alina, Müller, Tony A, Kreutmair, Stefanie, Albers, Corinna, Jakob, Lena, Lippert, Lena J, Yue, Zhenyu, Engelhardt, Monika, Follo, Marie, Zeiser, Robert, Huber, Tobias B, Duyster, Justus, Illert, Anna L

“…Autophagy is a genetically regulated process of adaptation to metabolic stress and was recently shown to be involved in the treatment response of chronic…”
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Murine Oncostatin M Has Opposing Effects on the Proliferation of OP9 Bone Marrow Stromal Cells and NIH/3T3 Fibroblasts Signaling through the OSMR by Jakob, Lena, Müller, Tony Andreas, Rassner, Michael, Kleinfelder, Helen, Veratti, Pia, Mitschke, Jan, Miething, Cornelius, Oostendorp, Robert A J, Pfeifer, Dietmar, Waterhouse, Miguel, Duyster, Justus

“…The IL-6 family cytokine Oncostatin M (OSM) is involved in cell development, growth, hematopoiesis, inflammation, and cancer. Intriguingly, OSM has…”
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PIM1 inhibition effectively enhances plerixafor-induced HSC mobilization by counteracting CXCR4 upregulation and blocking CXCL12 secretion by Müller, Tony Andreas, Pennisi, Sandra, Zwick, Anabel, Decker, Sarah, Klein, Claudius, Rister, Benjamin, Rudorf, Alina, Kissel, Sandra, Follo, Marie, Wäsch, Ralph, Illert, Anna Lena, Pfeifer, Dietmar, Oostendorp, Robert, Waskow, Claudia, Dierks, Christine, Duyster, Justus

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Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells by Mathew, Nimitha R, Braun, Lukas, O'Sullivan, David, Thomas, Simone, Waterhouse, Miguel, Hanke, Kathrin, Illert, Anna L, Duquesne, Sandra, Weber, Arnim, Tugues, Sonia, Follo, Marie, Claus, Rainer, Lübbert, Michael, Rummelt, Christoph, Bertz, Hartmut, Haag, Johanna, Schmidts, Andrea, Schultheiss, Michael, Bettinger, Dominik, Thimme, Robert, Ullrich, Evelyn, Tanriver, Yakup, Vuong, Giang Lam, Arnold, Renate, Hemmati, Philipp, Wolf, Dominik, Wilhelm, Konrad, Leiber, Christian, Gerull, Sabine, Lengerke, Claudia, Pabst, Thomas, Schroeder, Thomas, Rösler, Wolf, Metzelder, Stephan K, Brummer, Tilman, Hu, Zehan, Dengjel, Joern, Hackanson, Björn, Schmid, Christoph, Holtick, Udo, Scheid, Christof, Spyridonidis, Alexandros, Stölzel, Friedrich, Müller, Lutz P, Sicre-de-Fontbrune, Flore, Ihorst, Gabriele, Ehlert, Jan E, Wagner, Eva-Maria, Cahn, Jean-Yves, Schnell, Jacqueline, Kuchenbauer, Florian, Bunjes, Donald, Richardson, Simon, Gill, Saar, Kröger, Nicolaus, Ayuk, Francis, Vago, Luca, Ciceri, Fabio, Müller, Antonia M, Kondo, Takeshi, Teshima, Takanori, Klaeger, Susan, Kuster, Bernhard, Kim, Dennis (Dong Hwan), Dörfel, Daniela, Bethge, Wolfgang, Hilgendorf, Inken, Andrieux, Geoffroy, Börries, Melanie, Busch, Hauke, Magenau, John, Reddy, Pavan, Labopin, Myriam, Henden, Andrea S, Hill, Geoffrey R, Kennedy, Glen A, Sarma, Anita, McLornan, Donal, Mufti, Ghulam, Oran, Betul, Rezvani, Katayoun, Shah, Omid, Negrin, Robert S, Nagler, Arnon, Prinz, Marco, Burchert, Andreas, Neubauer, Andreas, Beelen, Dietrich, Mackensen, Andreas, Herr, Wolfgang, Becher, Burkhard, Socié, Gerard, Caligiuri, Michael A, Ruggiero, Eliana, Bonini, Chiara, Häcker, Georg, Duyster, Justus, Pearce, Erika, Blazar, Bruce R, Zeiser, Robert

“…Combining the kinase inhibitor sorafenib with allogeneic stem cell transplantation boosts immune responses against a subtype of acute myelogenous leukemia,…”
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Beclin-1 Phosphorylation By BCR-ABL Is Crucial for CML Leukemogenesis By Suppression of Autophagy by Yu, Chuanjiang, Gorantla, Sivahari Prasad, Mueller, Tony, Lippert, Lena, Yue, Zhenyu, Zeiser, Robert, Huber, Tobias, Duyster, Justus, Illert, Anna Lena

“…The constitutively activated chimeric Tyrosine kinase BCR-ABL is critical for initiation, progression and maintenance of chronic myelogenous leukemia (CML)…”
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JAK1/2 Inhibition Suppresses T Cell Proliferation and Inflammatory Cytokine Production In An Allogeneic Setting and Ameliorates Graft-Versus-Host Disease (GvHD) In a Murine GvHD Model by Spoerl, Silvia, Chen, Sophia, Bscheider, Michael, Mathew, Nimitha, Schmickl, Martina, Mueller, Tony, Schmitt-Graeff, Annette, Peschel, Christian, Duyster, Justus, Poeck, Hendrik, Zeiser, Robert, von Bubnoff, Nikolas

“…Graft-versus-host-disease (GvHD) constitutes a severe complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). In GvHD, tissue damage is…”
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