Different Actions of Deferoxamine and Iron on Ga-67 Abscess Detection in Rats

Different Actions of Deferoxamine and Iron on Ga-67 Abscess Detection in Rats

The contrast-enhancing properties of iron (Fe) and deferoxamine (DFO) in abscess imaging with Ga-67 citrate were compared in rats bearing turpentine-induced abscesses. Iron administration shifted Ga-67 from plasma into tissues such as muscle and fat. As a result, the abscess-to-plasma ratio increase...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of nuclear medicine (1978) Vol. 25; no. 6; pp. 668 - 672
Main Authors: Oberhaensli, Rolf D, Mueller, Rita M, Fridrich, Raimund
Format: Journal Article
Language:English
Published: United States Soc Nuclear Med 01-06-1984
Subjects:
Abscess - diagnostic imaging
Abscess - metabolism
Animals
Deferoxamine
Drug Evaluation, Preclinical
Female
Ferric Compounds
Gallium Radioisotopes - metabolism
Glucaric Acid
Iron - blood
Radionuclide Imaging
Rats
Rats, Inbred Strains
Time Factors
Tissue Distribution
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The contrast-enhancing properties of iron (Fe) and deferoxamine (DFO) in abscess imaging with Ga-67 citrate were compared in rats bearing turpentine-induced abscesses. Iron administration shifted Ga-67 from plasma into tissues such as muscle and fat. As a result, the abscess-to-plasma ratio increased whereas the abscess-to-muscle ratio decreased. DFO enhanced the abscess-to-muscle and abscess-to-plasma ratios by increasing urinary Ga-67 excretion. In contrast to Fe, DFO removed abscess-bound Ga-67, thus representing a disadvantage of DFO compared with Fe. As a result, the abscess-to-plasma ratio was more effectively enhanced by Fe than by DFO. We conclude that abscess imaging with Ga-67 citrate may be improved by administration of Fe for detection of abscesses masked by blood activity, or DFO for detection of abscesses surrounded by muscle tissue.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0161-5505
1535-5667