Search Results - "Mueller, Richard H."

A Practical Stereoselective Synthesis and Novel Cocrystallizations of an Amphiphatic SGLT-2 Inhibitor by Deshpande, Prashant P, Singh, Janak, Pullockaran, Annie, Kissick, Thomas, Ellsworth, Bruce A, Gougoutas, Jack Z, Dimarco, John, Fakes, Michael, Reyes, Mayra, Lai, Chiajen, Lobinger, Hidegard, Denzel, Theo, Ermann, Peter, Crispino, Gerard, Randazzo, Michael, Gao, Zenrong, Randazzo, Renee, Lindrud, Mark, Rosso, Victor, Buono, Frederic, Doubleday, Wendel W, Leung, Simon, Richberg, Pricilla, Hughes, David, Washburn, William N, Meng, Wei, Volk, Kevin J, Mueller, Richard H

“…A practical synthesis of the SGLT-2 inhibitor β-C-aryl-d-glucoside (1) has been developed. The route employed…”
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Insights Into Palladium-Catalyzed Cyanation of Bromobenzene: Additive Effects on the Rate-Limiting Step by Buono, Frederic G, Chidambaram, Rama, Mueller, Richard H, Waltermire, Robert E

“…Kinetic studies using reaction calorimetry were conducted under synthetically relevant conditions to study the effect of additives in the cyanation of…”
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Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632 by Xu, Zhongmin, Singh, Janak, Schwinden, Mark D, Zheng, Bin, Kissick, Thomas P, Patel, Bharat, Humora, Michael J, Quiroz, Fernando, Dong, Lin, Hsieh, Dau-Ming, Heikes, James E, Pudipeddi, Madhusudhan, Lindrud, Mark D, Srivastava, Sushil K, Kronenthal, David R, Mueller, Richard H

“…Development of an efficient and scalable process for the human immunodeficiency virus (HIV) protease inhibitor BMS-232632…”
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Efficient Asymmetric Synthesis of the Vasopeptidase Inhibitor BMS-189921 by Singh, Janak, Kronenthal, David R, Schwinden, Mark, Godfrey, Jollie D, Fox, Rita, Vawter, Edward J, Zhang, Bo, Kissick, Thomas P, Patel, Bharat, Mneimne, Omar, Humora, Michael, Papaioannou, Chris G, Szymanski, Walter, Wong, Michael K. Y, Chen, Chien K, Heikes, James E, DiMarco, John D, Qiu, Jun, Deshpande, Rajendra P, Gougoutas, Jack Z, Mueller, Richard H

“…An efficient asymmetric synthesis of the vasopeptidase inhibitor BMS-189921 was accomplished. Two short enantioselective syntheses of the common key…”
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Remarkable β-Selectivity in the Synthesis of β-1-C-Arylglucosides:  Stereoselective Reduction of Acetyl-Protected Methyl 1-C-Arylglucosides without Acetoxy-Group Participation by Deshpande, Prashant P, Ellsworth, Bruce A, Buono, Frederic G, Pullockaran, Annie, Singh, Janak, Kissick, Thomas P, Huang, Ming-H, Lobinger, Hildegard, Denzel, Theodor, Mueller, Richard H

“…An efficient and practical process to generate β-C-arylglucoside derivatives was achieved. The process described involves Lewis acid mediated ionic reduction…”
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A Practical Asymmetric Synthesis of the Antiviral Agent Lobucavir, BMS-180194 by Singh, Janak, Bisacchi, Gregory S, Ahmad, Saleem, Godfrey, Jollie D, Kissick, Thomas P, Mitt, Toomas, Kocy, Octavian, Vu, Truc, Papaioannou, Chris G, Wong, Michael K, Heikes, James E, Zahler, Robert, Mueller, Richard H

“…A practical synthesis of the antiviral agent lobucavir, [1R-(1α,2β,3α)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-6H-purin-6-one (BMS-180194), is described…”
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Microbial hydroxylation of o-bromophenylacetic acid: synthesis of 4-substituted-2,3-dihydrobenzofurans by Deshpande, Prashant P, Nanduri, Venkata B, Pullockaran, Annie, Christie, Hamish, Mueller, Richard H, Patel, Ramesh N

“…Microbial hydroxylation of o-bromophenylacetic acid provided 2-bromo-5-hydroxyphenylacetic acid. This enabled a route to the key intermediate…”
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Conversion of L-pyroglutamic acid to 4-alkyl-substituted L-prolines. The synthesis of trans-4-cyclohexyl-L-proline by Thottathil, John K, Moniot, Jerome L, Mueller, Richard H, Wong, Michael K. Y, Kissick, Thomas P

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Regioselective enzymatic aminoacylation of lobucavir to give an intermediate for lobucavir prodrug by Hanson, Ronald L, Shi, Zhongping, Brzozowski, David B, Banerjee, Amit, Kissick, Thomas P, Singh, Janak, Pullockaran, Annie J, North, Jeffrey T, Fan, Junying, Howell, Jeffrey, Durand, Susan C, Montana, Michael A, Kronenthal, David R, Mueller, Richard H, Patel, Ramesh N

“…Synthesis of lobucavir prodrug, L-valine, [(1 S,2 R,3 R)-3-(2-amino-1,6-dihydro-6-oxo-9 H-purin-9-yl)-2-(hydroxymethyl)cyclobutyl]methyl ester…”
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Regioselective Activation of Aminothiazole(iminoxyacetic acid)acetic Acid:  An Efficient Synthesis of the Monobactam Aztreonam by Singh, Janak, Denzel, Theodor W, Fox, Rita, Kissick, Thomas P, Herter, Rolf, Wurdinger, Joseph, Schierling, Peter, Papaioannou, Chris G, Moniot, Jerome L, Mueller, Richard H, Cimarusti, Christopher M

“…An efficient synthesis of the monobactam aztreonam…”
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Cupric bromide mediated oxidation of 4-carboxyoxazolines to the corresponding oxazoles by Barrish, Joel C, Singh, Janak, Spergel, Steven H, Han, Wen Ching, Kissick, Thomas P, Kronenthal, David R, Mueller, Richard H

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Ester enolate Claisen rearrangement. Construction of the prostanoid skeleton by Ireland, Robert E, Mueller, Richard H, Willard, Alvin K

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A Practical Synthesis of an Anti-Methicillin Resistant Staphylococcus aureus Cephalosporin BMS-247243 by Singh, Janak, Kim, Oak K, Kissick, Thomas P, Natalie, Kenneth J, Zhang, Bo, Crispino, Gerard A, Springer, Dane M, Wichtowski, John A, Zhang, Yunhui, Goodrich, Jason, Ueda, Yasutsugu, Luh, Bing Y, Burke, Brian D, Brown, Matthew, Dutka, Anthony P, Zheng, Bin, Hsieh, Dau-Ming, Humora, Michael J, North, Jeffrey T, Pullockaran, Anne J, Livshits, Juliya, Swaminathan, Shankar, Gao, Zhinong, Schierling, Peter, Ermann, Peter, Perrone, Robert K, Lai, Mei C, Gougoutas, Jack Z, DiMarco, John D, Bronson, Joanne J, Heikes, James E, Grosso, John A, Kronenthal, David R, Denzel, Theodor W, Mueller, Richard H

“…A practical synthesis of the anti-methicillin resistant Staphylococcus aureus cephem…”
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The ester enolate Claisen rearrangement. Stereochemical control through stereoselective enolate formation by Ireland, Robert E, Mueller, Richard H, Willard, Alvin K

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Diastereoselective Reaction of a Grignard Reagent with Chiral Imides:  A Practical Preparation of a Key Intermediate in the Synthesis of Ifetroban Sodium by Mueller, Richard H, Wang, Shaopeng, Pansegrau, Paul D, Jannotti, Joy Q, Poss, Michael A, Thottathil, John K, Singh, Janak, Humora, Michael J, Kissick, Thomas P, Boyhan, Brenda

“…A novel and highly efficient synthesis of [1S-(1α,2α,3α,4α)]-2-[[2-(3-methoxy-3-oxopropyl)phenyl]methyl]-7-oxabicyclo[2.2.1]heptane-3-carboxylic acid (A), a…”
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A Practical Asymmetric Synthesis of the Antiviral Agent Lobucavir, BMS-180194 by Singh, Janak, Bisacchi, Gregory S, Ahmad, Saleem, Godfrey, Jollie D, Kissick, Thomas P, Mitt, Toomas, Kocy, Octavian, Vu, Truc, Papaioannou, Chris G, Wong, Michael K, Heikes, James E, Zahler, Robert, Mueller, Richard H

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Claisen rearrangement of allyl esters by Ireland, Robert E, Mueller, Richard H

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Stereo- and regioselective total synthesis of the hydropyrido[2,1,6-de]quinolizine ladybug defensive alkaloids by Mueller, Richard H, Thompson, Mark E, DiPardo, Robert M

“…The stereo-and regioselective syntheses of the ladybug (Coccinella septempunctata ) defensive alkaloids coccinelline, precoccinelline ( plus or minus…”
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Synthesis of peristylane and the acs-(Cs)-C14-tetraquinane, C14-pentaquinane, and norperistylane systems by Eaton, Philip E, Mueller, Richard H, Carlson, Glenn R, Cullison, David A, Cooper, Gary F, Chou, Teh-Chang, Krebs, Ernst Peter

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Lithium bronze as a stoichiometric reagent for the conjugate reduction of .alpha.,.beta.-unsaturated ketones by Mueller, Richard H, Gillick, James G

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