Search Results - "Mueller, Kelly L"

Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib by Irwin, Mary E., Mueller, Kelly L., Bohin, Natacha, Ge, Yubin, Boerner, Julie L.

“…Epidermal growth factor receptor (EGFR) is overexpressed in many cancer types including ∼30% of breast cancers. Several small molecule tyrosine kinase…”
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Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of Met by Mueller, Kelly L, Madden, Julie M, Zoratti, Gina L, Kuperwasser, Charlotte, List, Karin, Boerner, Julie L

“…Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have shown clinical efficacy in lung, colon, and pancreatic cancers. In lung cancer,…”
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Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells by Mueller, Kelly L, Hunter, Lauren A, Ethier, Stephen P, Boerner, Julie L

“…Breast cancers are not responsive to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), although 30% of breast cancers overexpress EGFR…”
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Protein expression of DNA damage repair proteins dictates response to topoisomerase and PARP inhibitors in triple-negative breast cancer by Boerner, Julie L, Nechiporchik, Nicole, Mueller, Kelly L, Polin, Lisa, Heilbrun, Lance, Boerner, Scott A, Zoratti, Gina L, Stark, Karri, LoRusso, Patricia M, Burger, Angelika

“…Patients with metastatic triple-negative breast cancer (TNBC) have a poor prognosis. New approaches for the treatment of TNBC are needed to improve patient…”
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EGFR/Met association regulates EGFR TKI resistance in breast cancer by Mueller, Kelly L, Yang, Zeng-Quan, Haddad, Ramsi, Ethier, Stephen P, Boerner, Julie L

“…Breast cancers show a lack of response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), despite 30% of tumors expressing EGFR. The…”
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Abrogating phosphorylation of eIF4B is required for EGFR and mTOR inhibitor synergy in triple-negative breast cancer by Madden, Julie M., Mueller, Kelly L., Bollig-Fischer, Aliccia, Stemmer, Paul, Mattingly, Raymond R., Boerner, Julie L.

“…Triple-negative breast cancer (TNBC) patients suffer from a highly malignant and aggressive disease. They have a high rate of relapse and often develop…”
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EGFR Tyrosine 845 Phosphorylation-Dependent Proliferation and Transformation of Breast Cancer Cells Require Activation of p38 MAPK by Mueller, Kelly L, Powell, Katelyn, Madden, Julie M, Eblen, Scott T, Boerner, Julie L

“…Phosphorylation of epidermal growth factor receptor (EGFR) on tyrosine 845 by c-Src has been shown to be important for cell proliferation and migration in…”
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A targeted enzyme approach to sensitization of tyrosine kinase inhibitor-resistant breast cancer cells by Giordano, Courtney R., Mueller, Kelly L., Terlecky, Laura J., Krentz, Kendra A., Bollig-Fischer, Aliccia, Terlecky, Stanley R., Boerner, Julie L.

“…Gefitinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) of potential use in patients with breast cancer. Unfortunately, in…”
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Bicondylar tibial plateau fractures: a biomechanical study by Mueller, Kelly L, Karunakar, Madhav A, Frankenburg, Elizabeth P, Scott, Derek S

“…The optimal treatment of bicondylar tibial plateau fractures remains controversial. The current study was designed to answer the following questions: (1) can a…”
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Horner's syndrome after posterior spinal fusion in a child : A case report by MUELLER, Kelly L, LODER, Randall T, EGGENBERGER, Eric R, FARLEY, Frances A

“…A case report of a complication after posterior spinal fusion. To present the clinical findings of a Horner's syndrome after posterior spinal fusion. A…”
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Operative Treatment of Unstable Pediatric Pelvis and Acetabular Fractures by Karunakar, Madhav A, Goulet, James A, Mueller, Kelly L, Bedi, Asheesh, Le, Theodore T

“…The management of unstable pediatric pelvic and acetabular fractures continues to be controversial. Recent reports have suggested that closed management of…”
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Spontaneous Respiration Anesthesia for Respiratory Papillomatosis by Stern, Yoram, McCall, John E., Mueller, Kelly L., Willging, J. Paul, Cotton, Robin T.

“…Several anesthetic techniques for microlaryngeal laser surgery in children have been advocated. The objective of this study was to evaluate the operative…”
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Abstract 2911: EGFR and c-Src crosstalk in breast cancer cell migration by Mueller, Kelly L., Boerner, Julie L.

“…Abstract Patients with breast cancer do not respond to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in the clinic, although 56% of basal…”
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Abstract 269: Disruption of lipid rafts sensitizes EGFR expressing breast cancer cells to EGFR inhibitors by Irwin, Mary E., Mueller, Kelly L., Boerner, Julie L.

“…Abstract While therapeutic strategies have improved, ∼500,000 women worldwide die from breast cancer each year. Many proteins have been implicated in breast…”
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Abstract 278: Regulation of constitutive Met phosphorylation in breast cancer by EGFR by Mueller, Kelly L., Haddad, Ramsi, Yang, ZengQuan, Ethier, Stephen P., Boerner, Julie L.

“…Abstract Breast cancer remains a major health problem, despite advances in detection, diagnosis, and treatment. Four genomic subtypes of breast cancer have…”
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Protein Expression of DNA Damage Repair Proteins Dictates Response to Topoisomerase and PARP Inhibitors in Triple-Negative Breast Cancer: e0119614 by Boerner, Julie L, Nechiporchik, Nicole, Mueller, Kelly L, Polin, Lisa, Heilbrun, Lance, Boerner, Scott A, Zoratti, Gina L, Stark, Karri, LoRusso, Patricia M, Burger, Angelika

“…Patients with metastatic triple-negative breast cancer (TNBC) have a poor prognosis. New approaches for the treatment of TNBC are needed to improve patient…”
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EGFR Tyrosine 845 Phosphorylation-Dependent Proliferation and Transformation of Breast Cancer Cells Require Activation of p38 MAPK12 by Mueller, Kelly L, Powell, Katelyn, Madden, Julie M, Eblen, Scott T, Boerner, Julie L

“…Phosphorylation of epidermal growth factor receptor (EGFR) on tyrosine 845 by c-Src has been shown to be important for cell proliferation and migration in…”
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Operative Treatment of Unstable Pediatric Pelvis and Acetabular Fractures by Karunakar, Madhav A., Goulet, James A., Mueller, Kelly L., Bedi, Asheesh, Le, Theodore T.

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Superficial and deep posterior compartment syndrome following high tibial osteotomy for tibia vara in a child by Mueller, Kelly L, Farley, Frances A

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