Search Results - "Mueller, Kate R."

Regulation of the JNK3 signaling pathway during islet isolation: JNK3 and c-fos as new markers of islet quality for transplantation by Abdelli, Saida, Papas, Klearchos K, Mueller, Kate R, Murtaugh, Mike P, Hering, Bernhard J, Bonny, Christophe

“…Stress conditions generated throughout pancreatic islet processing initiate the activation of pro-inflammatory pathways and beta-cell destruction. Our goal is…”
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Silicone rubber membrane devices permit islet culture at high density without adverse effects by Avgoustiniatos, Efstathios S, Mueller, Kate R, Scott Iii, William E, Kitzmann, Jennifer P, Suszynski, Thomas M, Perrault, Brian E, Falde, Eric J, Balamurugan, A N, Hering, Bernhard J, Putnam, Charles W, Papas, Klearchos K

“…Conventional culture conditions, such as in T-flasks, require that oxygen diffuse through the medium to reach the islets; in turn, islet surface area density…”
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Differences in glucose-stimulated insulin secretion in vitro of islets from human, nonhuman primate, and porcine origin by Mueller, Kate R, Balamurugan, A N, Cline, Gary W, Pongratz, Rebecca L, Hooper, Rebecca L, Weegman, Bradley P, Kitzmann, Jennifer P, Taylor, Michael J, Graham, Melanie L, Schuurman, Henk-Jan, Papas, Klearchos K

“…Porcine islet xenotransplantation is considered a potential cell‐based therapy for type 1 diabetes. It is currently being evaluated in diabetic nonhuman…”
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Supplements in human islet culture: human serum albumin is inferior to fetal bovine serum by Avgoustiniatos, Efstathios S, Scott, 3rd, William E, Suszynski, Thomas M, Schuurman, Henk-Jan, Nelson, Rebecca A, Rozak, Phillip R, Mueller, Kate R, Balamurugan, A N, Ansite, Jeffrey D, Fraga, Daniel W, Friberg, Andrew S, Wildey, Gina M, Tanaka, Tomohiro, Lyons, Connor A, Sutherland, David E R, Hering, Bernhard J, Papas, Klearchos K

“…Culture of human islets before clinical transplantation or distribution for research purposes is standard practice. At the time the Edmonton protocol was…”
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Continuous Quadrupole Magnetic Separation of Islets during Digestion Improves Purified Porcine Islet Viability by Todd, Paul W., Balamurugan, Appakalai N., Hering, Bernhard J., Papas, Klearchos K., Hanley, Thomas R., Mueller, Kate R., Kitzmann, Jennifer P., Scott III, William E., Rizzari, Michael D., Suszynski, Thomas M., Kumar Sajja, Venkata Sunil, Weegman, Bradley P., Kennedy, David J.

“…Islet transplantation (ITx) is an emerging and promising therapy for patients with uncontrolled type 1 diabetes. The islet isolation and purification processes…”
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Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques by Graham, Melanie L., Ramachandran, Sabarinathan, Singh, Amar, Moore, Meghan E. G., Flanagan, E. Brian, Azimzadeh, Agnes, Burlak, Christopher, Mueller, Kate R., Martins, Kyra, Anazawa, Takayuki, Appakalai, Balamurugan N., Bansal‐Pakala, Pratima, Murtaugh, Michael P., O'Brien, Timothy D., Papas, Klearchos K., Spizzo, Thomas, Schuurman, Henk‐J., Hancock, Wayne W., Hering, Bernhard. J.

“…A safe, efficacious, and clinically applicable immunosuppressive regimen is necessary for islet xenotransplantation to become a viable treatment option for…”
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Epigenetic biomarkers indicate islet cell death in xenotransplantation by Faulk, Christopher, Mueller, Kate R., Cheishvili, David, Colwell, Mathia, Pepin, Anne‐Sophie, Syzf, Moshe, Hering, Bernhard J., Burlak, Christopher

“…BackgroundXenotransplantation of porcine islets has emerged in recent decades as a potential treatment for type 1 diabetes (T1D). Current methods of detection,…”
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In vitro characterization of neonatal, juvenile, and adult porcine islet oxygen demand, β‐cell function, and transcriptomes by Smith, Kate E., Purvis, William G., Davis, Melissa A., Min, Catherine G., Cooksey, Amanda M., Weber, Craig S., Jandova, Jana, Price, Nicholas D., Molano, Diana S., Stanton, James Brett, Kelly, Amy C., Steyn, Leah V., Lynch, Ronald M., Limesand, Sean W., Alexander, Michael, Lakey, Jonathan R. T., Seeberger, Karen, Korbutt, Gregory S., Mueller, Kate R., Hering, Bernhard J., McCarthy, Fiona M., Papas, Klearchos K.

“…Background There is currently a shortage of human donor pancreata which limits the broad application of islet transplantation as a treatment for type 1…”
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Xenotransplantation literature update, May-June 2015 by Burlak, Christopher, Mueller, Kate R., Beaton, Benjamin P.

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Manufacturing porcine islets: culture at 22 °C has no advantage above culture at 37 °C: a gene expression evaluation by Mueller, Kate R., Martins, Kyra V., Murtaugh, Michael P., Schuurman, Henk-Jan, Papas, Klearchos K.

“…Background The manufacturing process of islets includes a culture step which was originally introduced to ease the logistics of procedures in preparing the…”
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Real-time assessment of encapsulated neonatal porcine islets prior to clinical xenotransplantation by Kitzmann, Jennifer P., Law, Lee, Shome, Avik, Muzina, Marija, Elliott, Robert B., Mueller, Kate R., Schuurman, Henk-Jan, Papas, Klearchos K.

“…Kitzmann JP, Law L, Shome A, Muzina M, Elliott RB, Mueller KR, Schuurman H‐J, Papas KK. Real‐time assessment of encapsulated neonatal porcine islets prior to…”
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Function and expression of sulfonylurea, adrenergic, and glucagon-like peptide 1 receptors in isolated porcine islets by Kelly, Amy C., Steyn, Leah V., Kitzmann, Jenna P., Anderson, Miranda J., Mueller, Kate R., Hart, Nathaniel J., Lynch, Ronald M., Papas, Klearchos K., Limesand, Sean W.

“…The scarcity of human cadaveric pancreata limits large‐scale application of islet transplantation for patients with diabetes. Islets isolated from…”
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Manufacturing porcine islets: culture at 22 degree C has no advantage above culture at 37 degree C: a gene expression evaluation by Mueller, Kate R, Martins, Kyra V, Murtaugh, Michael P, Schuurman, Henk-Jan, Papas, Klearchos K

“…The manufacturing process of islets includes a culture step which was originally introduced to ease the logistics of procedures in preparing the graft and…”
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Improving Purified Islet Viability by Continuous Quadrupole Magnetic Separation (QMS) by Weegman, Bradley P, Sajja, Venkata SK, Rizzari, Michael D, Suszynski, Thomas M, Scott, William E, Kitzmann, Jennifer P, Mueller, Kate R, Hanley, Thomas R, Kennedy, David J, Todd, Paul W, Balamurugan, A N, Hering, Bernhard J, Papas, Kleachos K

“…Islet transplantation (ITx) is a minimally-invasive alternative to whole pancreas transplant for patients with uncontrolled type 1 diabetes. The islet…”
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Expression and Function of Sulfonylurea, Adrenergic, and Glucagon- Like Peptide 1 Receptors in Isolated Porcine Islets by Kelly, Amy C., Steyn, Leah V., Kitzmann, Jenna P., Anderson, Miranda J., Mueller, Kate R., Hart, Nathaniel, Lynch, Ronald, Papas, Klearchos K., Limesand, Sean W.

“…The scarcity of human cadaveric pancreata limits large-scale application of islet transplantation for patients with diabetes. Islets isolated from…”
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